Reliable measurement of elastic modulus of cells by nanoindentation in an atomic force microscope.

Abstract:

:The elastic modulus of an oral cancer cell line UM1 is investigated by nanoindentation in an atomic force microscope with a flat-ended tip. The commonly used Hertzian method gives apparent elastic modulus which increases with the loading rate, indicating strong effects of viscoelasticity. On the contrary, a rate-jump method developed for viscoelastic materials gives elastic modulus values which are independent of the rate-jump magnitude. The results show that the rate-jump method can be used as a standard protocol for measuring elastic stiffness of living cells, since the measured values are intrinsic properties of the cells.

authors

Zhou ZL,Ngan AH,Tang B,Wang AX

doi

10.1016/j.jmbbm.2011.11.010

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

134-42

eissn

1751-6161

issn

1878-0180

pii

S1751-6161(11)00298-0

journal_volume

8

pub_type

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