Abstract：
:Sylgard((R)) is a biocompatible elastomer which has been widely used in biomedical applications including in simulations of the mechanical response of soft tissues and mechanotransduction investigations. In this study the effect of fabrication parameters including base to curing agent ratio and curing time on the mechanical response of Sylgard((R)) was investigated and a novel fabrication technique for the production of mock arteries with highly uniform thickness, which is essential for mechanotransduction studies, is described. Finally a method for the surface treatment of Sylgard((R)) using sulphuric acid and fibronectin to enhance smooth muscle cell (SMC) adhesion is proposed and examined in vitro. Sylgard((R)) mock coronary arteries fabricated using the proposed technique exhibited a mechanical response close to arterial tissue with cell adhesion enhanced using the surface treatment techniques described.
journal_name
J Mech Behav Biomed Materauthors
Colombo A,Zahedmanesh H,Toner DM,Cahill PA,Lally Cdoi
10.1016/j.jmbbm.2010.04.003subject
Has Abstractpub_date
2010-08-01 00:00:00pages
470-7issue
6eissn
1751-6161issn
1878-0180pii
S1751-6161(10)00054-8journal_volume
3pub_type
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journal_title：Journal of the mechanical behavior of biomedical materials
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journal_title：Journal of the mechanical behavior of biomedical materials
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journal_title：Journal of the mechanical behavior of biomedical materials
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journal_title：Journal of the mechanical behavior of biomedical materials
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journal_title：Journal of the mechanical behavior of biomedical materials
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journal_title：Journal of the mechanical behavior of biomedical materials
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journal_title：Journal of the mechanical behavior of biomedical materials
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journal_title：Journal of the mechanical behavior of biomedical materials
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journal_title：Journal of the mechanical behavior of biomedical materials
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doi：10.1016/j.jmbbm.2016.08.019
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