Abstract：
:High intracranial pressure (ICP) can impede cerebral blood flow resulting in secondary injury or death following severe stroke. Compensatory mechanisms include reduced cerebral blood and cerebrospinal fluid volumes, but these often fail to prevent raised ICP. Serendipitous observations in intracerebral hemorrhage (ICH) suggest that neurons far removed from a hematoma may shrink as an ICP compliance mechanism. Here, we sought to critically test this observation. We tracked the timing of distal tissue shrinkage (e.g. CA1) after collagenase-induced striatal ICH in rat; cell volume and density alterations (42% volume reduction, 34% density increase; p < 0.0001) were highest day one post-stroke, and rebounded over a week across brain regions. Similar effects were seen in the filament model of middle cerebral artery occlusion (22% volume reduction, 22% density increase; p ≤ 0.007), but not with the Vannucci-Rice model of hypoxic-ischemic encephalopathy (2.5% volume increase, 14% density increase; p ≥ 0.05). Concerningly, this 'tissue compliance' appears to cause sub-lethal damage, as revealed by electron microscopy after ICH. Our data challenge the long-held assumption that 'healthy' brain tissue outside the injured area maintains its volume. Given the magnitude of these effects, we posit that 'tissue compliance' is an important mechanism invoked after severe strokes.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kalisvaart ACJ,Wilkinson CM,Gu S,Kung TFC,Yager J,Winship IR,van Landeghem FKH,Colbourne Fdoi
10.1038/s41598-020-78880-4subject
Has Abstractpub_date
2020-12-16 00:00:00pages
22013issue
1issn
2045-2322pii
10.1038/s41598-020-78880-4journal_volume
10pub_type
杂志文章abstract：:Hepatitis B virus (HBV) infection is a leading cause of hepatocellular carcinoma worldwide. However, the strategy of HBV to escape from the host immune system remains largely unknown. In this study, we examined extracellular vesicles (EVs) secreted from human hepatocytes infected with HBV. EVs includeing exosomes are ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07853-x
更新日期：2017-08-10 00:00:00
abstract：:Rubber-filler composites are a key component in the manufacture of tyres. The filler provides mechanical reinforcement and additional wear resistance to the rubber, but it in turn introduces non-linear mechanical behaviour to the material which most likely arises from interactions between the filler particles, mediate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07389
更新日期：2014-12-09 00:00:00
abstract：:There are a number of psychological phenomena in which dramatic emotional responses are evoked by seemingly innocuous perceptual stimuli. A well known example is the 'uncanny valley' effect whereby a near human-looking artifact can trigger feelings of eeriness and repulsion. Although such phenomena are reasonably well...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00864
更新日期：2012-01-01 00:00:00
abstract：:A novel process for improving tar yield through catalytic depolymerization of a typical lignite was put forward. The catalytic depolymerization of the lignite over CoCl2 and ZnCl2 catalyst in different concentrations were investigated by a Gray-King apparatus. The optimal catalyst concentrations of CoCl2 and ZnCl2 cat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14869-w
更新日期：2017-10-31 00:00:00
abstract：:Blood transfusion is fundamental in managing hematologic malignancies. We sought to evaluate the need and availability of blood products for patients with hematological malignancies at Uganda Cancer Institute. We prospectively studied the demand and supply of blood for patients with thrombocytopenia (platelet count ≤5...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59773-y
更新日期：2020-02-18 00:00:00
abstract：:Cisplatin is one of the most widely used chemotherapeutic agents in the treatment of different tumors but has high toxicity and side effects. Therefore, the synthesis of new chemotherapeutic agents is necessary, so that they are effective in the treatment of cancer while avoiding such toxicity. In this study, we have ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73488-0
更新日期：2020-10-07 00:00:00
abstract：:Dosimetry models using preclinical positron emission tomography (PET) data are commonly employed to predict the clinical radiological safety of novel radiotracers. However, unbiased clinical safety profiling remains difficult during the translational exercise from preclinical research to first-in-human studies for nov...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72830-w
更新日期：2020-09-29 00:00:00
abstract：:By combining the two basic deformation mechanisms for auxetic open-cell metamaterials, re-entrant angle and chirality, new hybrid chiral mechanical metamaterials are designed and fabricated via a multi-material 3D printer. Results from mechanical experiments on the 3D printed prototypes and systematic Finite Element (...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20795-2
更新日期：2018-02-05 00:00:00
abstract：:Peritoneal fibrosis (PF) is a severe complication of peritoneal dialysis, but there are few effective therapies for it. Recent studies have revealed a new biological function of trehalose as an autophagy inducer. Thus far, there are few reports regarding the therapeutic effects of trehalose on fibrotic diseases. There...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71230-4
更新日期：2020-08-31 00:00:00
abstract：:Thyroid hormone (TH) has long been believed to play a minor role in male reproduction. However, evidences from experimental model of thyrotoxicosis or hypothyroidism suggests its role in spermatogenesis. Cellular action of TH requires membrane transport via specific transporters such as monocarboxylate transporter 8 (...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67594-2
更新日期：2020-07-07 00:00:00
abstract：:In this paper, we evaluated the power of microbiome measures taken at three time points over the growth test period (weaning, 15 and 22 weeks) to foretell growth and carcass traits in 1039 individuals of a line of crossbred pigs. We measured prediction accuracy as the correlation between actual and predicted phenotype...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43031-x
更新日期：2019-04-25 00:00:00
abstract：:Adolescent alcohol exposure may increase anxiety-like behaviors by altering central monoaminergic functions and other important neuronal pathways. The present study was designed to investigate the anxiolytic effect of 0.5% γ-oryzanol (GORZ) and its neurochemical and molecular mechanisms under chronic 10% ethanol consu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67689-w
更新日期：2020-06-30 00:00:00
abstract：:During recent military operations, eye-related injuries have risen in frequency due to increased use of explosive weaponry which often result in corneal puncture injuries. These have one of the poorest visual outcomes for wounded soldiers, often resulting in blindness due to the large variations in injury shape, size,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61079-y
更新日期：2020-03-06 00:00:00
abstract：:Improving dewaterability of sludge is important for the disposal of sludge in wastewater treatment plants (WWTPs). This study, for the first time, investigated the Fe(II) activated oxidization processes in improving anaerobically digested sludge (ADS) dewaterability. The combination of Fe(II) (0-100 mg/g total solids ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24800
更新日期：2016-04-25 00:00:00
abstract：:The connection between structure and stability of ecological networks has been widely studied in the last fifty years. A challenge that scientists continue to face is that in-depth mathematical model analysis is often difficult, unless the considered systems are specifically constrained. This makes it challenging to g...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50373-z
更新日期：2019-10-01 00:00:00
abstract：:Activated sludge granules and flocs have their inherent advantages and disadvantages for wastewater treatment due to their different characteristics. So far quantitative information on their evaluation is still lacking. This work provides a quantitative and comparative evaluation on the characteristics and pollutant r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42910
更新日期：2017-02-17 00:00:00
abstract：:In utero and upon delivery, neonates are exposed to a wide array of microorganisms from various sources, including maternal bacteria. Prior studies have proposed that the mode of feeding shapes the gut microbiota and, subsequently the child's health. However, the effect of the mode of feeding and its influence on the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38309
更新日期：2016-12-06 00:00:00
abstract：:Accurate cancer diagnosis often requires extraction and purification of genetic materials from cells, and sophisticated instrumentations that follow. Otherwise in order to directly treat the diagnostic materials to cells, multiple steps to optimize dose concentration and treatment time are necessary due to diversity i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18497
更新日期：2015-12-18 00:00:00
abstract：:Both brain native inflammatory cells and infiltrated peripheral white blood cells (WBCs) are primary participants in the brain inflammatory damage post-TBI. Metabotropic glutamate receptor 5 (mGluR5) has been reported to regulate microglias and astrocytes to affect inflammation after TBI, but its effect on modulating ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10201-8
更新日期：2017-08-30 00:00:00
abstract：:Spontaneous isopeptide bond formation, a stabilizing posttranslational modification that can be found in gram-positive bacterial cell surface proteins, has previously been used to develop a peptide-peptide ligation technology that enables the polymerization of tagged-proteins catalyzed by SpyLigase. Here we adapted th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39291
更新日期：2016-12-16 00:00:00
abstract：:Non-alcoholic fatty liver disease (NAFLD) is a common liver disease. Previous studies on the association between Helicobacter pylori (HP) infection and NAFLD are inconsistent. Our study was aimed to find out the relationship between HP infection and NAFLD. We performed a large cross-sectional study in northern Chinese...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41371-2
更新日期：2019-03-19 00:00:00
abstract：:Functional integrity of eukaryotic organelles relies on direct physical contacts between distinct organelles. However, the entity of organelle-tethering factors is not well understood due to lack of means to analyze inter-organelle interactions in living cells. Here we evaluate the split-GFP system for visualizing org...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24466-0
更新日期：2018-04-18 00:00:00
abstract：:We have recently reported that Kupffer cells consist of two subsets, radio-resistant resident CD68+ Kupffer cells and radio-sensitive recruited CD11b+ Kupffer cells/macrophages (Mφs). Non-alcoholic steatohepatitis (NASH) is characterized not only by hepatic steatosis but also chronic inflammation and fibrosis. In the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34466
更新日期：2016-10-06 00:00:00
abstract：:We have studied the transformation of carbides in AISI M42 high-speed steels in the temperature window used for forging. The annealing was found to result in the partial transformation of the large, metastable M2C carbides into small, more stable grains of M6C, with an associated change in the crystal orientation. In ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16202
更新日期：2015-11-05 00:00:00
abstract：:Semen quality assessed by sperm count and sperm cell characteristics such as morphology and motility, is considered to be the main determinant of men's reproductive health. Therefore, sperm cell selection is vital in assisted reproductive technology (ART) used for the treatment of infertility. Conventional bright fiel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39523-5
更新日期：2019-03-05 00:00:00
abstract：:The live attenuated yellow fever (YF) vaccine is a highly effective human vaccine and induces long-term protective neutralizing antibodies directed against the viral envelope protein E. The generation of such antibodies requires the help of CD4 T cells which recognize peptides derived from proteins in virus particles ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09331-w
更新日期：2017-08-21 00:00:00
abstract：:The FGF receptor signaling pathway is recurrently involved in the leukemogenic processes. Oncogenic fusions of FGFR1 with various fusion partners were described in myeloid proliferative neoplasms, and overexpression and mutations of FGFR3 are common in multiple myeloma. In addition, fibroblast growth factors are abund...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38169-z
更新日期：2019-02-12 00:00:00
abstract：:A patient's pain during mandibular third molar extraction often creates problems for a dental surgeon and can also cause immense patient discomfort, such as decreased quality of life, serious complications, or even danger to the patients' lives. Effective pain management is therefore of great importance. Conventional ...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析,评审
doi：10.1038/srep40987
更新日期：2017-01-20 00:00:00
abstract：:The structure of metallic glasses is a long-standing question because the lack of long-range order makes diffraction based techniques difficult to be applied. Here, we used scanning tunneling microscopy with large tunneling resistance of 6 GΩ at low temperature in order to minimize forces between probe and sample and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13143
更新日期：2015-08-13 00:00:00
abstract：:To investigate the influence of various factors on the two outcome parameters "procedure - specific complication" (femoral head necrosis, infection, nonunion, femoral neck shortening, screw loosening, implant penetration) and "functional outcome" in patients with displaced and undisplaced femoral neck fracture treated...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57696-2
更新日期：2020-01-20 00:00:00
