Custom-made trays for targeted treatment of oral vesiculobullous diseases: A proposed protocol.

Abstract:

:Topical and intralesional corticosteroids (CS) are effective treatments for oral manifestations of autoimmune vesiculobullous diseases (VBD); however, may cause unnecessary absorption in the adjacent healthy mucosal surfaces, local infections, atrophy, and injection pain. To propose a protocol using a unique modality for targeted administration of CS for the treatment of local manifestations of oral VBD. The medical records of nine patients with systemic CS-resistant VBD oral lesions, were reviewed following 3 weeks of treatment and 3 months of tapering using a custom-made tray designed for precise application of topical CS targeted to the involved mucosa. Following treatment, lesions have healed in 8/9 patients. Involvement of surrounding mucosa was minimal, and no systemic adverse effects were recorded. The proposed protocol using custom-made trays for targeted CS treatment could be an effective alternative treatment for oral VBD.

journal_name

Dermatol Ther

journal_title

Dermatologic therapy

authors

Porat Ben Amy D,Kassem R

doi

10.1111/dth.14446

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

e14446

issue

6

eissn

1396-0296

issn

1529-8019

journal_volume

33

pub_type

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