Abstract:
:Acrodermatitis continua of Hallopeau (ACH) is a rare pustular psoriasis variant refractory to many conventional treatments. We report the successful treatment with secukinumab of a patient with a long history of ACH with marked onychodystrophy with frank pustulosis on the nail bed and with accompanying arthritis. Blockade of the IL-17 receptor A has shown promise in the treatment of psoriatic erythroderma and generalized pustular psoriasis not responsive to conventional treatment. A rapid response was observed in our patient, in both skin lesions and arthritic symptoms, underlining the ability of secukinumab to improve symptoms beyond those of plaque psoriasis.
journal_name
Dermatol Therjournal_title
Dermatologic therapyauthors
Galluzzo M,D'Adamio S,Teoli M,Bianchi L,Talamonti Mdoi
10.1111/dth.12899subject
Has Abstractpub_date
2019-05-01 00:00:00pages
e12899issue
3eissn
1396-0296issn
1529-8019journal_volume
32pub_type
杂志文章,评审abstract::Photodynamic therapy (PDT) is an established nonsurgical treatment for nodular basal cell carcinoma (nBCC). This study compares the clinical, histopathological, and immunohistochemical findings in recurrent nBCC after PDT versus pre-treatment (primary) nBCC. This retrospective study analyzed nodular BCCs treated with ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14779
更新日期:2021-01-13 00:00:00
abstract::Photodynamic therapy (PDT), traditionally used in patients with nonmelanoma skin cancer, has been found to be effective for various inflammatory skin conditions. Daylight-activated PDT (DL-PDT), in which the sun serves as the light source, is substantially less painful than conventional PDT. This study aimed to determ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14329
更新日期:2020-11-01 00:00:00
abstract::Postherpetic neuralgia (PHN) is a debilitating disease characterized by continuous, intense pain following an outbreak of herpes zoster. The pain associated with PHN can severely affect a patient's quality of life, quality of sleep, and ability to participate in activities of daily living. The aim of this study was to...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13181
更新日期:2020-01-01 00:00:00
abstract::Although there is still some controversy about the existence of psoriatic arthritis as a specific form of inflammatory arthritis associated with psoriasis, epidemiological, and clinical studies support the unique features of psoriatic arthritis. Because of lack of diagnostic or classification criteria, the disease has...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1396-0296.2004.04038.x
更新日期:2004-01-01 00:00:00
abstract::This article refers to papulosquamous diseases that are seen in the elderly. Many of these diseases are complex to diagnose due to the fact that they are difficult to identify, because they may resemble a similar disorder, which can be misleading. The problem that is frequently seen with these diseases is that they ar...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1046/j.1529-8019.2003.01633.x
更新日期:2003-01-01 00:00:00
abstract::Zoonoses are infectious diseases that can be transmitted from animals to humans. Transmission occurs directly or through vectors such as ticks, mosquitoes, or flies. The causative agents include bacteria, parasites, viruses, and fungi. Domestic pets and livestock, as well as wild animals, can be the source of disease....
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2009.01248.x
更新日期:2009-07-01 00:00:00
abstract::Androgenetic alopecia also known as pattern alopecia, is a disorder characterized by the gradual onset of the conversion of terminal hairs into vellus hairs. Dexpanthenol has an anti-oxidative and anti-inflammatory effect and a cellular repair capability. We present nine male cases who had marked improvement after rec...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13381
更新日期:2020-05-01 00:00:00
abstract::Cumulative exposure to ultraviolet radiation (UVR) increases the risk of developing skin cancer, particularly squamous cell carcinoma and basal cell carcinoma. Thus, the need for protection from the sun is widely advocated, but consumers generally associate such protection with the occasional extreme exposure and tend...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1396-0296.2004.04s1007.x
更新日期:2004-01-01 00:00:00
abstract::Pustulosis palmoplantaris (PPP; synonyms: pustulosis palmaris et plantaris, palmoplantar amicrobic pustulosis) is a common chronic, relapsing, pustular eruption affecting the palms and soles. The authors report the successful treatment of six therapy-experienced patients with histologically confirmed PPP with oral itr...
journal_title:Dermatologic therapy
pub_type: 临床试验,杂志文章
doi:10.1111/j.1529-8019.2008.01219.x
更新日期:2009-01-01 00:00:00
abstract::Tinea are superficial fungal infections caused by dermatophytes. Luliconazole exhibits highest antifungal activity against Trichophyton spp. which are major causative agents of dermatophytosis. However, luliconazole suffers from drawbacks such as less skin retention, low aqueous solubility and poor skin penetration. T...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13959
更新日期:2020-11-01 00:00:00
abstract::Verrucas are often recalcitrant to conventional cryotherapy. Since 1970, intralesional bleomycin has been used off-label by dermatologists. But in some cases, the results of intralesional bleomycin were disappointing. Vincristine is a well-known vinca alkaloid antiblastic drug that has been used for treating hematolog...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/j.1529-8019.2011.01425.x
更新日期:2011-05-01 00:00:00
abstract::Chronic venous leg ulcers (CVLU) are chronic wounds, associated with long-standing venous hypertension, which have a poor prognosis for healing. In the process of wound healing the first step is represented by platelet aggregation and subsequent release of growth factors and other mediators, which play a key role in t...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/j.1529-8019.2008.00196.x
更新日期:2008-07-01 00:00:00
abstract::Generalized eruptive keratoacanthoma, is considered a serious condition because the eruptions are diffuse, persistent, and recurrent. Constant pruritus, visceral neoplasms, and unsatisfactory response to treatment are ominous prognostic factors. Even if skin cancers are usually well controlled with surgical and/or rad...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12374
更新日期:2016-09-01 00:00:00
abstract::The Dangguikushen (DGKS) pill is a proprietary traditional Chinese medicine that has shown superior efficacy in the treatment of acne vulgaris for many years. A network pharmacology-based analysis was performed to explore the potential anti-acne compounds, core therapeutic targets, and the main pathways, involved in t...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14061
更新日期:2020-11-01 00:00:00
abstract::Large difficult to heal ulcers of various etiologies carry a high morbidity and mortality rate. Becaplermin is a recombinant platelet-derived growth factor approved for treatment of diabetic ulcers. In this two-case series, we report the use of becaplermin in the treatment of ulcers due to (i) calciphylaxis, an often ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12318
更新日期:2016-03-01 00:00:00
abstract::Treatment of severe psoriasis (PsO) in organ transplant (OT) patients is difficult. In fact, systemic drugs used for PsO therapy can be detrimental to transplanted organs and/or can increase the risk of serious infections in subjects already taking antireject medicines. Current guidelines fail to give indications on h...
journal_title:Dermatologic therapy
pub_type: 信件
doi:10.1111/dth.12909
更新日期:2019-05-01 00:00:00
abstract::There are many developmental abnormalities that may appear in the neonate and in infants when critical steps in embryogenesis fail. These steps are often not fatal but can lead to significant morbidity for those patients affected. A logical approach is needed in addressing both the diagnostic and therapeutic issues th...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2005.05016.x
更新日期:2005-03-01 00:00:00
abstract::A 57-year-old Caucasian female presented to our clinic with her 23-year-old son, who was profoundly autistic. Our patient was convinced that her son had an infestation with fibers and believed that he had developed the condition as a young child. She described the symptoms of the infestation in her son's skin on his b...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12724
更新日期:2018-11-01 00:00:00
abstract::Cyclosporine A (CYA) belongs to calcineurin inhibitor family, which has the ability to selectively suppress T cells. Owing to its immune-modulatory effects, it had been in use for graft vs host diseases and organ transplant rejection for many years, but in dermatology, it was first approved for use in 1997 in the trea...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.13934
更新日期:2020-11-01 00:00:00
abstract::Itch is an extremely frequent and enervating symptom of many diseases. Current anti-itch therapy, which is based almost exclusively on an "immunocentric" viewpoint, is often unsatisfactory. Recent studies show that this symptom is in fact the result of a complex interplay among skin, nervous system, endocrine system, ...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2005.00030.x
更新日期:2005-07-01 00:00:00
abstract::The highest efficacy of oral propranolol is for infantile hemangioma (IH) in the proliferative phase. Evaluation of the effectiveness of oral propranolol is less established when it is administered in late infancy following the proliferative phase. We aimed to assess the clinical outcomes of pediatric patients managed...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13331
更新日期:2020-05-01 00:00:00
abstract::Eccrine porocarcinoma (EPC) is a rare cutaneous neoplasm that grows slowly over a long period of time but often experiences an accelerated growth phase. This malignant tumor may arise denovo or evolve from a pre-existing benign eccrine poroma. Histologic evaluation demonstrates anaplastic cells involving the epidermis...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2008.00243.x
更新日期:2008-11-01 00:00:00
abstract::Onychomycosis is an important medical disorder affecting both health and quality of life of patients. This study was done to compare the efficacy of CO2 laser in combination with topical tioconazole versus CO2 laser only versus topical tioconazole alone in onychomycosis. A total of 120 patients with onychomycosis were...
journal_title:Dermatologic therapy
pub_type: 杂志文章,随机对照试验
doi:10.1111/dth.13155
更新日期:2020-01-01 00:00:00
abstract::Psoriasis is a chronic skin inflammatory disorder with frequent relapse. Ceramides and their key enzymes are deficient in the lesions, resulting in impaired epidermal permeability barrier, which correlates with disease severity. We evaluated the efficacy of linoleic acid-ceramide moisturizer (LA-Cer) as an adjunctive ...
journal_title:Dermatologic therapy
pub_type: 杂志文章,随机对照试验
doi:10.1111/dth.12259
更新日期:2015-11-01 00:00:00
abstract::Acne cysts are a common dermatological problem that often leads to scarring and a significant negative impact on patients' psyche. The aim of the study was to evaluate the usefulness of intralesional foam sclerotherapy for the treatment of cystic acne. Patients with cystic acne treated with intralesional foam scleroth...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13505
更新日期:2020-11-01 00:00:00
abstract::The purpose of the work was to assess changes in chemerin and irisin levels in women with diagnosed intrahepatic cholestasis of pregnant women treated with ursodeoxycholic acid. The study group consisted of 50 patients with diagnosed and confirmed intrahepatic cholestasis of pregnant women at 24-25 weeks of pregnancy ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13272
更新日期:2020-03-01 00:00:00
abstract::Covering wounds, acute and chronic, is one of the most fundamental activities of any medical practitioner. Although wound dressings primarily serve to contain the "good" and keep out the "bad," research has characterized more specifically the sophisticated interaction between the human wound bed and its dressing count...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.12055
更新日期:2013-05-01 00:00:00
abstract::Management of keloid is difficult, so there is always a need for adequate and effective therapy. In this study, we explored and compared the efficacy and synergistic effect of combined intralesional radiofrequency (RF) and intralesional triamcinolone acetonide (TAC) with intralesional triamcinolone acetonide alone in ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13919
更新日期:2020-11-01 00:00:00
abstract::Tinea pedis affects the life quality distinctly and patients those with a prolonged disease often resort to non-medical methods. We sought to evaluate patients' knowledge about tinea pedis and approaches to the non-pharmacological agents. A cross-sectional study was conducted on 152 patients with tinea pedis who answe...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14041
更新日期:2020-11-01 00:00:00
abstract::The oral mucosa is a common site for collateral damage of cancer therapies, including radiation, cytotoxic medication, and newer targeted therapies. Ulcerative oral mucositis is typically painful and affects oral functions including speech, and oral intake of food and medications, thus impacting the quality of life. D...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2011.01434.x
更新日期:2011-07-01 00:00:00