Network pharmacology-based identification for therapeutic mechanisms of Dangguikushen pill in acne vulgaris.

Abstract:

:The Dangguikushen (DGKS) pill is a proprietary traditional Chinese medicine that has shown superior efficacy in the treatment of acne vulgaris for many years. A network pharmacology-based analysis was performed to explore the potential anti-acne compounds, core therapeutic targets, and the main pathways, involved in the DGKS pill bioactivity. The matching results between the predicted targets of the DGKS pill and the well-known targets of acne vulgaris were collected, followed by network establishment using protein-protein interaction (PPI) data. Cytoscape was utilized to analyze the network and screen the core targets. Furthermore, the Database for Annotation, Visualization and Integrated Discovery (DAVID), and ClueGO were used for the enrichment analysis of the Kyoto Encyclopedia of Genes and Genomics (KEGG) pathways and Gene Ontology biological processes (GO-BP). Finally, the "compound-target-pathway" network was constructed. This approach identified 19 active compounds, 46 therapeutic targets, and 12 core therapeutic targets of the DGKS pill. The biological processes were primarily related to reactive oxygen species (ROS) metabolic process, gland morphogenesis, and female gonad development. The DGKS pill was significantly associated with eight pathways including the PI3K-Akt, TNF, NF-kappa B, and p53 signaling pathways. DGKS pill might have a synergistic effect on the inhibition of excessive sebaceous lipogenesis and sebocyte differentiation, and likewise, anti-inflammatory effects via the different signaling pathways (PI3K-Akt, TNF, NF-kappa B, and p53).

journal_name

Dermatol Ther

journal_title

Dermatologic therapy

authors

Yu B,Diao NN,Zhang Y,Li XZ,Yu N,Ding YF,Shi YL

doi

10.1111/dth.14061

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

e14061

issue

6

eissn

1396-0296

issn

1529-8019

journal_volume

33

pub_type

杂志文章
  • Methotrexate vs secukinumab safety in psoriasis patients with metabolic syndrome.

    abstract::The safety of methotrexate in psoriasis patients with metabolic syndrome could be argued because of increased risk of liver toxicity. The aim of the study was to investigate the safety of methotrexate compared with secukinumab in psoriasis patients with metabolic syndrome. A controlled, open trial in psoriasis patient...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.14281

    authors: Gisondi P,Bellinato F,Bruni M,De Angelis G,Girolomoni G

    更新日期:2020-11-01 00:00:00

  • A patient with delusional infestation by proxy: Issues for vulnerable adults.

    abstract::A 57-year-old Caucasian female presented to our clinic with her 23-year-old son, who was profoundly autistic. Our patient was convinced that her son had an infestation with fibers and believed that he had developed the condition as a young child. She described the symptoms of the infestation in her son's skin on his b...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.12724

    authors: Hussain K,Gkini MA,Taylor R,Shinhmar S,Bewley A

    更新日期:2018-11-01 00:00:00

  • Evaluation of the effect of surgical treatment on quality of life with the Dermatology Life Quality Index in patients with facial nonmelanoma skin cancer.

    abstract::Skin cancers are the most common type of cancer. Nonmelanoma skin cancers (NMSCs) are more common than melanoma. Although the mortality rate is low, cancer word can be frightening for patients. Surgery is the main treatment. As skin cancers are most commonly located on the face, undesirable cosmetic results can occur ...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.14094

    authors: Çetinarslan T,Evrenos MK,Bilaç C,Özyurt B,Türel Ermertcan A

    更新日期:2020-11-01 00:00:00

  • Diagnosis and treatment of cutaneous paraneoplastic disorders.

    abstract::The skin plays a critical role in the detection of internal malignances. Cutaneous signs of these disorders afford clinicians opportunities for early diagnosis and treatment. We aim to succinctly review the recognition, diagnosis, and treatment of selected cutaneous paraneoplastic diseases. Skin disorders that may be ...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1529-8019.2010.01371.x

    authors: Abreu Velez AM,Howard MS

    更新日期:2010-11-01 00:00:00

  • Custom-made trays for targeted treatment of oral vesiculobullous diseases: A proposed protocol.

    abstract::Topical and intralesional corticosteroids (CS) are effective treatments for oral manifestations of autoimmune vesiculobullous diseases (VBD); however, may cause unnecessary absorption in the adjacent healthy mucosal surfaces, local infections, atrophy, and injection pain. To propose a protocol using a unique modality ...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.14446

    authors: Porat Ben Amy D,Kassem R

    更新日期:2020-11-01 00:00:00

  • Adjusting oral oxybutynin medication for hyperhidrosis to reflect seasonal temperature variations.

    abstract::Most studies of oral oxybutynin (OOx) for the treatment of hyperhidrosis (HH) have assumed a stable treatment protocol, without taking into account adverse effects (AE) or seasonal variations in temperature. The objective is to evaluate adjusting the dose of OOx according to the time of year. Prospective study of pati...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.12615

    authors: Del Boz J,Millán-Cayetano JF,García-Montero P,García-Harana C,Rivas-Ruiz F,de Troya-Martín M

    更新日期:2018-07-01 00:00:00

  • Timing of quality of life improvements in psoriatic patients treated with different systemic therapies.

    abstract::Psoriasis impacts the quality of life (QoL) by disrupting overall health and social life. Thus, the use of a QoL evaluation item is crucial in assessing a therapeutic regimen. Also, faster improvements in QoL lead to better patient compliance, but very few studies compare psoriasis traditional and biologic therapies t...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.13021

    authors: Pistone G,Gurreri R,Tilotta G,Caruso P,Curiale S,Bongiorno MR

    更新日期:2019-09-01 00:00:00

  • Urticaria mimickers in children.

    abstract::Acute urticaria is a self-limited cutaneous condition marked by transient, erythematous, and pruritic wheals. It is a hypersensitivity response that is often secondary to infection, medications, or food allergies in children. In contrast, the urticarial "mimickers" described in this review article are often seen in th...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/dth.12103

    authors: Mathur AN,Mathes EF

    更新日期:2013-11-01 00:00:00

  • Urticarial rash, fever, and arthritis: A case of refractory Adult-onset Still's disease with good response to tocilizumab.

    abstract::Adult-onset Still's disease (AOSD) is a rare, systemic inflammatory disorder of not completely understood etiology. Aberrant activation of the innate immune system and overproduction of several pro-inflammatory mediators are considered a critical component in disease pathogenesis. AOSD still poses a challenge due to t...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/dth.13041

    authors: Wawrzycki B,Krasowska D,Pietrzak A,Wielosz E,Majdan M,Lotti T

    更新日期:2019-09-01 00:00:00

  • Dermoscopic characterization of guttate psoriasis, pityriasis rosea, and pityriasis lichenoides chronica in dark skin phototypes: An observational study.

    abstract::Dermoscopy as a diagnostic tool is attaining impetus in inflammatory dermatoses with the cumulative description of characteristic findings in most dermatoses obviating at times the need of biopsy. In this retrospective observational study, 20 histopathology confirmed cases each of pityriasis rosea (PR), guttate psoria...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.14631

    authors: Jindal R,Chauhan P,Sethi S

    更新日期:2020-12-05 00:00:00

  • Breaking paradigms in the treatment of psoriasis: Use of botulinum toxin for the treatment of plaque psoriasis.

    abstract::Some studies have demonstrated that neurotransmitters are involved in the pathogenesis of numerous skin conditions, including psoriasis, addressing the close correlation between the skin and the central nervous system. There are reports showing psoriasis improvement after peripheral nervous system injury. In addition,...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.14319

    authors: González C,Franco M,Londoño A,Valenzuela F

    更新日期:2020-11-01 00:00:00

  • Fractional CO2 laser: a novel therapeutic device for refractory necrobiosis lipoidica.

    abstract::Necrobiosis lipoidica diabeticorum is a granulomatous skin disease of uncertain pathogenesis. Many therapeutic approaches have been reported in the literature, but none of them can be considered the gold standard. Fractional CO(2) laser treatment shows peculiar effects in the skin, mainly due to its ability of modula...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/j.1529-8019.2012.01531.x

    authors: Buggiani G,Tsampau D,Krysenka A,De Giorgi V,Hercogová J

    更新日期:2012-11-01 00:00:00

  • Practical retinoid chemoprophylaxis in solid organ transplant recipients.

    abstract::Solid organ transplant recipients are at a significantly increased risk of developing skin cancer. Both systemic and topical retinoids are useful for chemosuppression of skin cancer in this patient population. These drugs can reduce both the present extent and the future development of premalignant and malignant skin ...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1529-8019.2005.05006.x

    authors: Neuhaus IM,Tope WD

    更新日期:2005-01-01 00:00:00

  • Topical application of a linoleic acid-ceramide containing moisturizer exhibit therapeutic and preventive benefits for psoriasis vulgaris: a randomized controlled trial.

    abstract::Psoriasis is a chronic skin inflammatory disorder with frequent relapse. Ceramides and their key enzymes are deficient in the lesions, resulting in impaired epidermal permeability barrier, which correlates with disease severity. We evaluated the efficacy of linoleic acid-ceramide moisturizer (LA-Cer) as an adjunctive ...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/dth.12259

    authors: Liu M,Li X,Chen XY,Xue F,Zheng J

    更新日期:2015-11-01 00:00:00

  • The use of oral antibiotics in treating acne vulgaris: a new approach.

    abstract::Although acne is not an infectious disease, oral antibiotics have remained a mainstay of treatment over the last 40 years. The anti-inflammatory properties of oral antibiotics, particularly the tetracyclines, are efficacious in treating inflammatory acne lesions. Common prescribing practices in Dermatology exert signi...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/dth.12370

    authors: Farrah G,Tan E

    更新日期:2016-09-01 00:00:00

  • A pilot comparative study of topical latanoprost and tacrolimus in combination with narrow-band ultraviolet B phototherapy and microneedling for the treatment of nonsegmental vitiligo.

    abstract::Prostaglandins and their analogues are beneficial as topical agents in vitiligo treatment, yet neither of the previous study addressed their comparative efficiency with conventional topical agents used in vitiligo treatment. In this pilot (24 patients) left-right comparative study we addressed efficiency of prostaglan...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.12383

    authors: Korobko IV,Lomonosov KM

    更新日期:2016-11-01 00:00:00

  • Acridone acetic acid, sodium salt, as an agent to stop vitiligo progression: a pilot study.

    abstract::Vitiligo progression is attributed to immune system malfunctioning, thus immunomodulating compounds might be beneficial in stopping vitiligo progression which is a prerequisite for successful repigmentation. The goal of this study was to assess efficacy of acridone acetic acid, sodium salt (Na-AAA), an immunomodulatin...

    journal_title:Dermatologic therapy

    pub_type: 临床试验,杂志文章

    doi:10.1111/dth.12121

    authors: Korobko IV,Lomonosov KM

    更新日期:2014-07-01 00:00:00

  • The impact of COVID-19 pandemic on the management of patients with chronic urticaria: An observational two-center study from Turkey.

    abstract::The Coronavirus Disease 2019 (COVID-19) outbreak significantly affected the clinical practice in hospitals and the management of many diseases. The aim of this study was to evaluate the effect of pandemic-related factors on the severity and course of chronic urticaria (CU). A total of 194 CU patients who were on regul...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.14652

    authors: Erdem Y,Polat Ekinci A,Altunay IK,Sivaz O,Inal S,Gokalp MO,Pehlivan G,Özkaya E

    更新日期:2020-12-10 00:00:00

  • Clinical research in dermatology: 10 steps to getting started.

    abstract::Clinical research plays a very important role in the development of drugs and devices, including those for wound healing. The process of initiating a clinical trial can be rather daunting, particularly with the ever-increasing regulatory hurdles. Many clinicians are generally either not trained or have limited knowled...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/j.1529-8019.2006.00095.x

    authors: Carson PA

    更新日期:2006-11-01 00:00:00

  • The attitudes, behaviors, and opinions about non-pharmacological agents in patients with tinea pedis.

    abstract::Tinea pedis affects the life quality distinctly and patients those with a prolonged disease often resort to non-medical methods. We sought to evaluate patients' knowledge about tinea pedis and approaches to the non-pharmacological agents. A cross-sectional study was conducted on 152 patients with tinea pedis who answe...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.14041

    authors: Kara Polat A,Akın Belli A,Göre Karaali M,Koku Aksu AE

    更新日期:2020-11-01 00:00:00

  • Dexpanthenol may be a novel treatment for male androgenetic alopecia: Analysis of nine cases.

    abstract::Androgenetic alopecia also known as pattern alopecia, is a disorder characterized by the gradual onset of the conversion of terminal hairs into vellus hairs. Dexpanthenol has an anti-oxidative and anti-inflammatory effect and a cellular repair capability. We present nine male cases who had marked improvement after rec...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.13381

    authors: Kutlu Ö

    更新日期:2020-05-01 00:00:00

  • In vivo confocal reflectance microscopy in melanoma.

    abstract::Reflectance confocal microscopy (RCM) enables the noninvasive in vivo imaging of the skin with a horizontal axis and a cellular-level resolution allowing the study of the skin from superficial layers to papillary dermis. It has arisen an important tool in the study of tumors and specially an important role in the char...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/j.1529-8019.2012.01495.x

    authors: Carrera C,Puig S,Malvehy J

    更新日期:2012-09-01 00:00:00

  • Bioactive: A new era of bioactive ingredients in topical formulations for inflammatory dermatoses.

    abstract::Moisturization is the pillar of daily skin care and has significant benefit in improving hydration, strengthening the skin barrier, and ameliorating inflammatory dermatoses. Bioactive ingredients such as endocannabinoids, bioactive lipids, growth factors, microbiome modulators, and antioxidant enzymes are increasingly...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.13101

    authors: Yang EJ,Hendricks AJ,Beck KM,Shi VY

    更新日期:2019-11-01 00:00:00

  • Treatment of patch-stage mycosis fungoides with topical corticosteroids.

    abstract::Experience at the University of California, San Francisco (UCSF), in the management of patch-stage mycosis fungoides (MF) with topical, predominantly high-potency, corticosteroids is reviewed. The technique of applications is discussed in detail. Approximately 200 patients have been treated. The results are very favor...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1396-0296.2003.01639.x

    authors: Zackheim HS

    更新日期:2003-01-01 00:00:00

  • Treatment of pruritus in early-stage hypopigmented mycosis fungoides with aprepitant.

    abstract::Pruritus is a symptom that significantly affects the patient's quality of life in cutaneous T cell lymphoma (CTCL). The most effective treatments are those that address the condition itself; however, it is often not possible to control this symptom. Lymphoma-related pruritus normally becomes more severe as CTCL progre...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.12113

    authors: Jiménez Gallo D,Albarrán Planelles C,Linares Barrios M,Fernández Anguita MJ,Márquez Enríquez J,Rodríguez Mateos ME

    更新日期:2014-05-01 00:00:00

  • Serum soluble CD163 and proinflammatory chemokines may be biomarkers of the onset of adverse events in dabrafenib plus trametinib combination therapy for advanced melanoma.

    abstract::Various adverse events (AEs) have been reported to occur at a high rate in patients treated with dabrafenib plus trametinib (D + T) combination therapy. Among such AEs, the incidence of pyrexia was highest among the series of AEs in patients treated with D + T combination therapy. Although little is known about the me...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.14544

    authors: Amagai R,Fujimura T,Muto Y,Kambayashi Y,Furudate S,Ohuchi K,Okuma T,Hashimoto A,Aiba S

    更新日期:2020-11-14 00:00:00

  • Recalcitrant trametinib-induced paronychia treated successfully with topical timolol in a pediatric patient.

    abstract::Paronychia has been described as a side effect in patients undergoing treatment with MEK (mitogen activated protein kinase enzyme) inhibitors. It is usually a recurrent condition that can have a significant impact in the quality of life. Topical beta blocker treatment has been described as an effective therapy in anti...

    journal_title:Dermatologic therapy

    pub_type: 信件

    doi:10.1111/dth.13164

    authors: Martínez-de-Espronceda I,Bernabeu-Wittel J,Azcona M,Monserrat MT

    更新日期:2020-01-01 00:00:00

  • Hypertrophic lichen planus - successful treatment with acitretin.

    abstract::Lichen planus classifies into different subtypes according to morphology and location. Hypertrophic LP (HLP) manifests a great challenge due to persistent itching, the risk to develop into squamous cell carcinoma and therapeutic resistance. We report two clinical cases exemplary for the successful treatment of dramati...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.12337

    authors: Alamri A,Alsenaid A,Ruzicka T,Wolf R

    更新日期:2016-05-01 00:00:00

  • Treatment of oral lichen planus using 308-nm excimer laser.

    abstract::Oral lichen planus (OLP) is a chronic inflammatory disease, has prolonged courses, repeated attacks and resistance to treatment. The traditional narrow spectrum UVB treatment has an established efficacy on skin lichen planus, and high safety. However, most of ultraviolet phototherapy devices have a huge volume, thereb...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.12510

    authors: Liu WB,Sun LW,Yang H,Wang YF

    更新日期:2017-09-01 00:00:00

  • Successful treatment of porocarcinoma with maxacalcitol and imiquimod.

    abstract::This is the first report of a case of porocarcinoma that was successfully treated with maxacalcitol and imiquimod. ...

    journal_title:Dermatologic therapy

    pub_type: 信件

    doi:10.1111/dth.12830

    authors: Nagasawa T,Hirata A,Niiyama S,Enomoto Y,Fukuda H

    更新日期:2019-03-01 00:00:00