Abstract:
:Chronic venous leg ulcers (CVLU) are chronic wounds, associated with long-standing venous hypertension, which have a poor prognosis for healing. In the process of wound healing the first step is represented by platelet aggregation and subsequent release of growth factors and other mediators, which play a key role in the repair response. Platelet gel (PG), a hemocomponent obtained by mixing platelets, thrombin, and calcium, is able, when applied topically, to release platelet mediators that likely favor CVLU healing. However, unstandardized protocols have been described in studies utilizing PG for the regeneration of a number of tissues, including CVLU; the relative clinical outcomes were hence highly variable. In our experience the topical use of PG, together with the strict adherence to the principles of good wound care, quickly promoted increased granulation tissue, followed by a complete CVLU epithelization. Although further studies and trials are needed to establish the major outcome affecting rules for optimal indications, preparation, and use of PG for CVLU treatment, PG can be undoubtedly considered a useful tool, able to improve the management of CVLU.
journal_name
Dermatol Therjournal_title
Dermatologic therapyauthors
Ficarelli E,Bernuzzi G,Tognetti E,Bussolati O,Zucchi A,Adorni D,De Panfilis Gdoi
10.1111/j.1529-8019.2008.00196.xsubject
Has Abstractpub_date
2008-07-01 00:00:00pages
S13-7eissn
1396-0296issn
1529-8019pii
DTH196journal_volume
21 Suppl 1pub_type
杂志文章abstract::Objective of this open, noninterventional, noncontrolled study was to investigate the tolerability and performance of a woad extract containing cream in subjects with dry, pruritic skin after twice daily application over 2 weeks. Assessments included sensorial characteristics, skin condition, pruritus (numeric rating ...
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journal_title:Dermatologic therapy
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