Abstract:
:Intralesional methotrexate (il-MTX) has been reported as a useful therapy in keratoacanthoma (KA) and cutaneous squamous cell carcinoma (cSCC). However, the data available on the histological changes induced by this therapy are very scarce. We conducted a single center, prospective study that included 65 cases of cSCC treated with il-MTX before surgical treatment. Two histological studies were conducted in all patients: before intralesional treatment and after surgical removal. Lesions were assessed longitudinally both clinically and histologically. 60 patients (92.3%) responded to il-MTX treatment. There were no differences regarding aggressive histological features of the cSCC between responder and non-responder patients. All cases showed a chronic inflammatory infiltrate after il-MTX. Intratumoral necrosis areas were frequently observed. All cases showed local fibrosis with fine thickening of collagen bundles. Il-MTX induces a chronic lymphohistiocytic inflammatory reaction in both clinical responder and nonresponder patients. Tumor involution after il-MTX is followed by a fine fibrosis that explains the great cosmetic results and improves the accuracy of the follow-up.
journal_name
Dermatol Therjournal_title
Dermatologic therapyauthors
Bergón-Sendín M,Parra-Blanco V,Pulido-Pérez A,Nieto-Benito LM,Rosell-Díaz ÁM,Suárez-Fernández Rdoi
10.1111/dth.14377subject
Has Abstractpub_date
2020-11-01 00:00:00pages
e14377issue
6eissn
1396-0296issn
1529-8019journal_volume
33pub_type
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