Histological findings after intralesional methotrexate treatment in cutaneous squamous cell carcinoma.

Abstract:

:Intralesional methotrexate (il-MTX) has been reported as a useful therapy in keratoacanthoma (KA) and cutaneous squamous cell carcinoma (cSCC). However, the data available on the histological changes induced by this therapy are very scarce. We conducted a single center, prospective study that included 65 cases of cSCC treated with il-MTX before surgical treatment. Two histological studies were conducted in all patients: before intralesional treatment and after surgical removal. Lesions were assessed longitudinally both clinically and histologically. 60 patients (92.3%) responded to il-MTX treatment. There were no differences regarding aggressive histological features of the cSCC between responder and non-responder patients. All cases showed a chronic inflammatory infiltrate after il-MTX. Intratumoral necrosis areas were frequently observed. All cases showed local fibrosis with fine thickening of collagen bundles. Il-MTX induces a chronic lymphohistiocytic inflammatory reaction in both clinical responder and nonresponder patients. Tumor involution after il-MTX is followed by a fine fibrosis that explains the great cosmetic results and improves the accuracy of the follow-up.

journal_name

Dermatol Ther

journal_title

Dermatologic therapy

authors

Bergón-Sendín M,Parra-Blanco V,Pulido-Pérez A,Nieto-Benito LM,Rosell-Díaz ÁM,Suárez-Fernández R

doi

10.1111/dth.14377

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

e14377

issue

6

eissn

1396-0296

issn

1529-8019

journal_volume

33

pub_type

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