Long-term efficacy of biologics in the treatment of psoriasis: what do we really know?

abstract：:Physicians and patients have come to expect that our prescription topicals not only be efficacious but also minimally irritating and cosmetically pleasing. Much research and development effort are being spent to identify new vehicles to achieve these goals. Consumers are also demanding nonprescription products that gi...

journal_title：Dermatologic therapy

authors： Hougeir FG,Kircik L

更新日期：2012-05-01 00:00:00

abstract：:Lichen planus classifies into different subtypes according to morphology and location. Hypertrophic LP (HLP) manifests a great challenge due to persistent itching, the risk to develop into squamous cell carcinoma and therapeutic resistance. We report two clinical cases exemplary for the successful treatment of dramati...

journal_title：Dermatologic therapy

authors： Alamri A,Alsenaid A,Ruzicka T,Wolf R

更新日期：2016-05-01 00:00:00

abstract：:The purpose of the work was to assess changes in chemerin and irisin levels in women with diagnosed intrahepatic cholestasis of pregnant women treated with ursodeoxycholic acid. The study group consisted of 50 patients with diagnosed and confirmed intrahepatic cholestasis of pregnant women at 24-25 weeks of pregnancy ...

journal_title：Dermatologic therapy

authors： Dąbrowski K,Kierach R,Grabarek BO,Boroń D,Kukla M

更新日期：2020-03-01 00:00:00

abstract：:Basal cell carcinoma (BCC) is the most common malignancy in Caucasians, and its incidence is increasing. Most BCCs are treated surgically, nevertheless surgery is not an effective treatment for locally advanced or metastatic BCC. Alterations in hedgehog signaling pathway, a key regulator of cell growth and differentia...

journal_title：Dermatologic therapy

authors： Spallone G,Sollena P,Ventura A,Fargnoli MC,Gutierrez C,Piccerillo A,Tambone S,Bianchi L,Peris K

更新日期：2019-11-01 00:00:00

abstract：:Growth factors play an important role in reversing the effects of skin aging mediated by chronological and environmental factors. Excessive oxidation of intra- and extracellular components result in breakdown of collagen and elastin network in the dermis and produce the effect of facial aging. Topical application of h...

journal_title：Dermatologic therapy

authors： Mehta RC,Fitzpatrick RE

更新日期：2007-09-01 00:00:00

abstract：:The efficacy and safety of efalizumab in the treatment of moderate-to-severe chronic psoriasis has been established in studies of up to 3 years' duration. This study aims to describe the efficacy of up to 15 months' treatment with efalizumab and the convenience of therapy in patients with moderate-to-severe chronic pl...

journal_title：Dermatologic therapy

authors： Toth DP,Papp K,Gratton D

更新日期：2008-11-01 00:00:00

abstract：:The safety of methotrexate in psoriasis patients with metabolic syndrome could be argued because of increased risk of liver toxicity. The aim of the study was to investigate the safety of methotrexate compared with secukinumab in psoriasis patients with metabolic syndrome. A controlled, open trial in psoriasis patient...

journal_title：Dermatologic therapy

authors： Gisondi P,Bellinato F,Bruni M,De Angelis G,Girolomoni G

更新日期：2020-11-01 00:00:00

abstract：:Itch is an extremely frequent and enervating symptom of many diseases. Current anti-itch therapy, which is based almost exclusively on an "immunocentric" viewpoint, is often unsatisfactory. Recent studies show that this symptom is in fact the result of a complex interplay among skin, nervous system, endocrine system, ...

journal_title：Dermatologic therapy

authors： Guarneri C,Terranova M,Terranova G,Guarneri F

更新日期：2005-07-01 00:00:00

abstract：:Plantar warts can cause pain near the toes and the sole of the foot and may result in referral for treatment. This study was aimed at comparing 40% trichloroacetic acid (TCA) and cryotherapy (Cryo) for the treatment of plantar warts. This single-blind, randomized clinical trial was performed on 60 subjects presenting ...

journal_title：Dermatologic therapy

authors： Karrabi M,Kheirkhah M,Shahrestanaki E,Thomas S,Sahebkar M

更新日期：2020-07-01 00:00:00

abstract：:Vitiligo progression is attributed to immune system malfunctioning, thus immunomodulating compounds might be beneficial in stopping vitiligo progression which is a prerequisite for successful repigmentation. The goal of this study was to assess efficacy of acridone acetic acid, sodium salt (Na-AAA), an immunomodulatin...

journal_title：Dermatologic therapy

authors： Korobko IV,Lomonosov KM

更新日期：2014-07-01 00:00:00

abstract：:Pemphigus is a group of autoimmune diseases characterized by the formation of erosions and/or flaccid bullae of the skin and/or mucosae. The definition "drug-induced pemphigus" has been coined to indicate cases of pemphigus with clinical, histological and immunopathologic features similar to those of the idiopathic di...

journal_title：Dermatologic therapy

authors： Palleria C,Bennardo L,Dastoli S,Iannone LF,Silvestri M,Manti A,Nisticò SP,Russo E,De Sarro G

更新日期：2019-01-01 00:00:00

abstract：:Acne is known as a chronic inflammatory skin disease with sever adverse effects on quality of life in the patients. The increasing resistance to antibiotics has decreased their effectiveness in treating acne. As viable microbial dietary supplements, probiotics provide health benefits through fighting pathogens and mai...

journal_title：Dermatologic therapy

authors： Goodarzi A,Mozafarpoor S,Bodaghabadi M,Mohamadi M

更新日期：2020-05-01 00:00:00

abstract：:Soft-tissue augmentation with hyaluronic acid and calcium hydroxyl apatite are among the most widely used minimally invasive cosmetic treatments for the correction of contour deficiencies and wrinkles of the face without the risk, recovery time, and expense of a major surgery. Training and experience in the art and sc...

journal_title：Dermatologic therapy

authors： Redbord KP,Busso M,Hanke CW

更新日期：2011-01-01 00:00:00

abstract：:Few studies have reported Fractional Carbon Dioxide (FCO2) laser use in treating alopecia areata (AA), yet, effectiveness of this therapy has not been comparatively analyzed. To assess efficacy and safety of FCO2 laser in comparison to traditional intralesional corticosteroids injection (ILCs) in treatment of AA. This...

journal_title：Dermatologic therapy

authors： El-Husseiny R,Elframawy S,Abdallah M

更新日期：2020-07-01 00:00:00

abstract：:Management of keloid is difficult, so there is always a need for adequate and effective therapy. In this study, we explored and compared the efficacy and synergistic effect of combined intralesional radiofrequency (RF) and intralesional triamcinolone acetonide (TAC) with intralesional triamcinolone acetonide alone in ...

journal_title：Dermatologic therapy

authors： Kaushal V,Kumar S,Brar BK,Singh A

更新日期：2020-11-01 00:00:00

abstract：:Psoriasis is a chronic skin inflammatory disorder with frequent relapse. Ceramides and their key enzymes are deficient in the lesions, resulting in impaired epidermal permeability barrier, which correlates with disease severity. We evaluated the efficacy of linoleic acid-ceramide moisturizer (LA-Cer) as an adjunctive ...

journal_title：Dermatologic therapy

authors： Liu M,Li X,Chen XY,Xue F,Zheng J

更新日期：2015-11-01 00:00:00

abstract：:Reflectance confocal microscopy (RCM) enables the noninvasive in vivo imaging of the skin with a horizontal axis and a cellular-level resolution allowing the study of the skin from superficial layers to papillary dermis. It has arisen an important tool in the study of tumors and specially an important role in the char...

journal_title：Dermatologic therapy

authors： Carrera C,Puig S,Malvehy J

更新日期：2012-09-01 00:00:00

abstract：:The reported efficacy of various treatments for alopecia is difficult to compare based on a general lack of consideration in case reports/series and clinical trials of the spontaneous regrowth or baseline prognostic factors seen in alopecia areata and a general lack of quantification of hair growth. This report will g...

journal_title：Dermatologic therapy

authors： Olsen EA

更新日期：2011-05-01 00:00:00

abstract：:Psoriasis is a chronic, systemic inflammatory disease that in the moderate to severe forms may benefit of biologics, namely TNF and IL-12/23 and IL-17 inhibitors. Loss of response, lack of response, or discontinuation due to adverse events represent a concrete therapeutic challenge for dermatologists that have to swit...

journal_title：Dermatologic therapy

authors： Damiani G,Conic RRZ,de Vita V,Costanzo A,Regazzini R,Pigatto PDM,Bragazzi NL,Pacifico A,Malagoli P

更新日期：2019-03-01 00:00:00

abstract：:Although there is still some controversy about the existence of psoriatic arthritis as a specific form of inflammatory arthritis associated with psoriasis, epidemiological, and clinical studies support the unique features of psoriatic arthritis. Because of lack of diagnostic or classification criteria, the disease has...

journal_title：Dermatologic therapy

authors： Gladman DD

更新日期：2004-01-01 00:00:00

abstract：:Lyophilized-growth factors (L-GFs), is a new platelet rich plasma (PRP) preparation that is standardized in growth factors concentrations. The aim of this study was to compare the therapeutic efficacy of ablative fractional CO2 laser in combination with L-GFs vs PRP in post-acne scars. This study was conducted on 45 p...

journal_title：Dermatologic therapy

authors： Neinaa YME,Al-Khayat LA,Suliman GAM,Ameen TE

更新日期：2020-11-01 00:00:00

abstract：:Psoriasis is associated with an increased risk of atherosclerosis. The objective of this study is evaluate the relationship between carotid intima-media thickness (CIMT) serum and cystatin-C, fetuin-A levels in determining the increased risk of subclinical atherosclerosis in psoriasis patients. In this study, age and ...

journal_title：Dermatologic therapy

authors： Demirbaş A,Kurtipek GS,Tunçez A,Akyürek F,Demirbaş GU

更新日期：2020-11-01 00:00:00

abstract：:This article presents a short summary of our current knowledge of cicatricial alopecia disease pathogenesis and the hypothetical disease mechanisms that may be involved in scarring alopecia development. Several forms of scarring alopecia likely involve targeted cytotoxic action against hair follicle cells mediated by ...

journal_title：Dermatologic therapy

authors： McElwee KJ

更新日期：2008-07-01 00:00:00

abstract：:Scleredema is a deposition disorder which presents as diffuse, symmetric, non-pitting skin induration from dermal deposits of glycosaminoglycans ("mucins"). It classically affects the upper back and posterior neck, often causing skin tightness and decreased range of motion. In most patients the clinical course is chro...

journal_title：Dermatologic therapy

authors： Kennemer C,Pavlidakey P,Sami N

更新日期：2017-07-01 00:00:00

abstract：:Papillon-Lefèvre syndrome (PLS) is a rare disorder characterized by diffuse palmoplantar erythematous, fissured hyperkeratosis, and aggressive periodontal disease that starts in the early periods of childhood. Periodontal disease occurs with the early loss of deciduous teeth at the age of 2 to 4 years, followed by the...

journal_title：Dermatologic therapy

authors： Giannetti L,Apponi R,Dello Diago AM,Jafferany M,Goldust M,Sadoughifar R

更新日期：2020-05-01 00:00:00

abstract：:The incidences of fungal infections have greatly increased over the past few years, particularly in humid and industrialized areas. The severity of such infections ranges from being asymptomatic-mild to potentially life-threatening systemic infections. There are limited classes of drugs that are approved for the treat...

journal_title：Dermatologic therapy

authors： Waghule T,Sankar S,Rapalli VK,Gorantla S,Dubey SK,Chellappan DK,Dua K,Singhvi G

更新日期：2020-11-01 00:00:00

abstract：:Isotretinoin is a safe and useful medication for acne management. Adverse effects are mostly related to cutaneous and mucous membranes. We present a case of a 24-year-old female patient who was on treatment with isotretinoin for acne vulgaris Grade 4. After 6 months of treatment, the patient presented with localized p...

journal_title：Dermatologic therapy

authors： Gupta M,Lotti T,Goldust M

更新日期：2020-05-01 00:00:00

abstract：:Eccrine porocarcinoma (EPC) is a rare cutaneous neoplasm that grows slowly over a long period of time but often experiences an accelerated growth phase. This malignant tumor may arise denovo or evolve from a pre-existing benign eccrine poroma. Histologic evaluation demonstrates anaplastic cells involving the epidermis...

journal_title：Dermatologic therapy

authors： Brown CW Jr,Dy LC

更新日期：2008-11-01 00:00:00

abstract：:Photodynamic therapy (PDT), traditionally used in patients with nonmelanoma skin cancer, has been found to be effective for various inflammatory skin conditions. Daylight-activated PDT (DL-PDT), in which the sun serves as the light source, is substantially less painful than conventional PDT. This study aimed to determ...

journal_title：Dermatologic therapy

authors： Kremer N,Sherman S,Lapidoth M,Enk CD,Leshem YA,Mimouni T,Dudkiewicz D,Hodak E,Levi A

更新日期：2020-11-01 00:00:00

abstract：:Objective of this open, noninterventional, noncontrolled study was to investigate the tolerability and performance of a woad extract containing cream in subjects with dry, pruritic skin after twice daily application over 2 weeks. Assessments included sensorial characteristics, skin condition, pruritus (numeric rating ...

journal_title：Dermatologic therapy

authors： Forner C,Zeidler C,Stein P,Stössel E,Wefelmeier L,Peukert N,Isermann D,Ständer S

更新日期：2019-07-01 00:00:00