When IL-17 inhibitors fail: Real-life evidence to switch from secukinumab to adalimumab or ustekinumab.

abstract：:Nucleosomes are typically located intracellularly, and extracellular levels of nucleosomes indicated the degree of cell death. We postulated aberrant nucleosomes expression in dermatomyositis (DM) and polymyositis (PM). To assess the aberrant expression of circulating nucleosomes in DM and polymyositis. 76 consecutive...

journal_title：Dermatologic therapy

authors： Zhong D,Wu C,Bai J,Zhao J,Xu D,Li M,Wang Q,Wang F,Zeng X

更新日期：2020-11-01 00:00:00

abstract：:Alopecia areata (AA) is a common disease that results in nonscarring hair loss. Recently, tofacitinib (TOFA) has been a novel promising therapy for AA. The aim of this study is to determine the efficacy of oral TOFA treatment for alopecia areata (AA), and alopecia universalis (AU). Data of nine patients treated with o...

journal_title：Dermatologic therapy

authors： Akdogan N,Ersoy-Evans S,Doğan S,Atakan N

更新日期：2019-11-01 00:00:00

abstract：:Generalized eruptive keratoacanthoma, is considered a serious condition because the eruptions are diffuse, persistent, and recurrent. Constant pruritus, visceral neoplasms, and unsatisfactory response to treatment are ominous prognostic factors. Even if skin cancers are usually well controlled with surgical and/or rad...

journal_title：Dermatologic therapy

authors： Ribero S,Balagna E,Sportoletti Baduel E,Picciotto F,Sanlorenzo M,Fierro MT,Quaglino P,Macripo G

更新日期：2016-09-01 00:00:00

abstract：:Many traditional Chinese medicine compositions can moisturize the skin and utilize in cosmetics. Using a combination of Chinese Medicine Materials and guided by Traditional Chinese Medicine principles, this study selected Echinacea purpurea to protect the skin barrier, Dendrobium nobile to clear heat and promote fluid...

journal_title：Dermatologic therapy

authors： Meng H,Li J,Dong Y,He Y,Ren H,Liu Y,Qu Z,Zhang W,Zhang L,Bao T,Yi F

更新日期：2020-11-01 00:00:00

abstract：:Past studies have reported associations between psoriasis, metabolic syndrome, and atherosclerotic cardiovascular disease. According to studies, N-terminal pro B-type natriuretic peptide (NT-proBNP) is a useful screening test for cardiac disease. We examined the serum NT-proBNP level in patients with psoriasis and com...

journal_title：Dermatologic therapy

authors： Shahidi-Dadras M,Niknezhad N,Niknejad N,Zargari O

更新日期：2019-05-01 00:00:00

abstract：:Non-peristomal postoperative pyoderma gangrenosum (PPG) is a rare subtype of pyoderma gangrenosum that occurs in the early postoperative period at surgical incisions, most commonly after breast surgery. Early diagnosis and treatment is essential to prevent severe scaring. TNF-alpha inhibitor infliximab was reported to...

journal_title：Dermatologic therapy

authors： Ariane M,Bouaziz JD,de Masson A,Jachiet M,Bagot M,Lepelletier C

更新日期：2019-01-01 00:00:00

abstract：:Pruritus is associated with various skin diseases, dry skin, and with it an impaired skin barrier function. The study objective was to investigate short-term and long-term effects of two emollients on symptoms and skin barrier functions in xerotic eczema. Randomized, double-blind, study enrolling females/males, with b...

journal_title：Dermatologic therapy

authors： Simon D,Nobbe S,Nägeli M,Barysch M,Kunz M,Borelli S,Hasan-Ali O,Wildi E,Gasser UE

更新日期：2018-11-01 00:00:00

abstract：:Large difficult to heal ulcers of various etiologies carry a high morbidity and mortality rate. Becaplermin is a recombinant platelet-derived growth factor approved for treatment of diabetic ulcers. In this two-case series, we report the use of becaplermin in the treatment of ulcers due to (i) calciphylaxis, an often ...

journal_title：Dermatologic therapy

authors： Twu O,Mednik S,Scumpia P,Doaty S,Worswick S

更新日期：2016-03-01 00:00:00

abstract：:Few studies have reported Fractional Carbon Dioxide (FCO2) laser use in treating alopecia areata (AA), yet, effectiveness of this therapy has not been comparatively analyzed. To assess efficacy and safety of FCO2 laser in comparison to traditional intralesional corticosteroids injection (ILCs) in treatment of AA. This...

journal_title：Dermatologic therapy

authors： El-Husseiny R,Elframawy S,Abdallah M

更新日期：2020-07-01 00:00:00

abstract：:Experience at the University of California, San Francisco (UCSF), in the management of patch-stage mycosis fungoides (MF) with topical, predominantly high-potency, corticosteroids is reviewed. The technique of applications is discussed in detail. Approximately 200 patients have been treated. The results are very favor...

journal_title：Dermatologic therapy

authors： Zackheim HS

更新日期：2003-01-01 00:00:00

abstract：:Basal cell carcinoma (BCC) is the most common malignancy in Caucasians, and its incidence is increasing. Most BCCs are treated surgically, nevertheless surgery is not an effective treatment for locally advanced or metastatic BCC. Alterations in hedgehog signaling pathway, a key regulator of cell growth and differentia...

journal_title：Dermatologic therapy

authors： Spallone G,Sollena P,Ventura A,Fargnoli MC,Gutierrez C,Piccerillo A,Tambone S,Bianchi L,Peris K

更新日期：2019-11-01 00:00:00

abstract：INTRODUCTION:There are an increasing number of biologic drugs in the pipeline for treating hidradenitis suppurativa (HS). Clinical trials for these drugs usually share the same clinical selection criteria. OBJECTIVES:(a) To describe the clinical profile of HS patients receiving first-line biologic treatment in an HS c...

journal_title：Dermatologic therapy

authors： Montero-Vilchez T,Salvador-Rodriguez L,Sanchez-Diaz M,Cuenca-Barrales C,Martinez-Lopez A,Arias-Santiago S,Molina-Leyva A

更新日期：2020-11-01 00:00:00

abstract：:Pigmented lesions represent an enormous range of conditions, from benign to malignant tumors, and from infectious to post-inflammatory. Pigmented lesions are much less easily diagnosed on anogenital skin, and clinicians should have a low threshold for biopsy confirmation of diseases not classic in appearance. ...

journal_title：Dermatologic therapy

authors： Edwards L

更新日期：2010-09-01 00:00:00

abstract：:Psoriasis is a chronic skin inflammatory disorder with frequent relapse. Ceramides and their key enzymes are deficient in the lesions, resulting in impaired epidermal permeability barrier, which correlates with disease severity. We evaluated the efficacy of linoleic acid-ceramide moisturizer (LA-Cer) as an adjunctive ...

journal_title：Dermatologic therapy

authors： Liu M,Li X,Chen XY,Xue F,Zheng J

更新日期：2015-11-01 00:00:00

abstract：:Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe adverse cutaneous drug reaction with mortality up to 10%. It is a rare condition with risk varying between 1 in 1000 and 1 in 10 000 drug exposures. The aim of the study was to describe clinical features, management and drugs responsible for cau...

journal_title：Dermatologic therapy

authors： Sandhu S,Neema S,Vashisht D,Venugopal R,Sengupta P,Radhakrishnan S

更新日期：2020-12-14 00:00:00

abstract：:The World Health Organization has recently defined the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections as a pandemic. The infection, which may cause a potentially very severe respiratory disease, now called coronavirus disease 2019 (COVID-19), has airborne transmission via droplets while less a...

journal_title：Dermatologic therapy

authors： Elsaie ML,Nada HA

更新日期：2020-09-01 00:00:00

abstract：:For many years, drug therapies were not explicitly studied in the pediatric population. The lack of data forced clinicians to treat children using empiric therapy, often guessing at the treatment dose. In addition to the lack of dosing information, there was no evidence that a product would be safe and efficacious in ...

journal_title：Dermatologic therapy

authors： Mathis L,Rodriguez W

更新日期：2009-05-01 00:00:00

abstract：:Bexarotene is a retinoid that specifically binds retinoid X receptors and has numerous effects on cellular growth and differentiation. It is approved for the treatment of cutaneous T cell lymphoma both topically and systemically. Adverse effects include hyperlipidemia, central hypothyroidism, and neutropenia with bexa...

journal_title：Dermatologic therapy

authors： Schadt CR

更新日期：2013-09-01 00:00:00

abstract：:Surgery as treatment for local invasive cutaneous squamous cell carcinoma (cSCC) is not always feasible due to the age and/or the health status of patients. Thus, the investigation of new strategies to improve the quality of life of them is required. The aim of this work is to investigate two chemotherapy agents indiv...

journal_title：Dermatologic therapy

authors： Gil S,Yébenes M,Luelmo J,Alsina M,Sabés M

更新日期：2016-09-01 00:00:00

abstract：:Clinical research plays a very important role in the development of drugs and devices, including those for wound healing. The process of initiating a clinical trial can be rather daunting, particularly with the ever-increasing regulatory hurdles. Many clinicians are generally either not trained or have limited knowled...

journal_title：Dermatologic therapy

authors： Carson PA

更新日期：2006-11-01 00:00:00

abstract：:Daylight-photodynamic therapy (D-PDT) and ingenol mebutate (IM) are novel therapies directed to actinic keratoses (AK). The purpose of our study was to compare effectiveness, tolerability, cosmetic outcome and patient preference of D-PDT versus IM in the treatment of grade I and II AK. Twenty-seven patients with AK on...

journal_title：Dermatologic therapy

authors： Genovese G,Fai D,Fai C,Mavilia L,Mercuri SR

更新日期：2016-05-01 00:00:00

abstract：:Psoriasis of the scalp, face, intertriginous areas, genitals, hands, feet, and nails is often underdiagnosed, and disease management can be challenging. Despite the small surface area commonly affected by psoriasis in these locations, patients have disproportionate levels of physical impairment and emotional distress....

journal_title：Dermatologic therapy

authors： Merola JF,Qureshi A,Husni ME

更新日期：2018-05-01 00:00:00

abstract：:The ultraviolet (UV) light spectrum has long been known to induce biologic effect on the skin. For a large number of cutaneous disorders, phototherapy and photochemotherapy are effective therapeutic options with excellent safety profiles and well-documented side effects. Despite their ease of administration and benefi...

journal_title：Dermatologic therapy

authors： Sage RJ,Lim HW

更新日期：2010-01-01 00:00:00

abstract：:Several treatment modalities are used for the treatment of acne scars with variable results. Recent studies showed that fractional radiofrequency may be an effective treatment modality for acne scars. The objective of this study was to assess the efficacy, safety, tolerability and patient satisfaction of fractional bi...

journal_title：Dermatologic therapy

authors： Verner I

更新日期：2016-01-01 00:00:00

abstract：:Photodermatoses can be classified into five general categories: 1) idiopathic photodermatoses, including polymorphic light eruption (PMLE), actinic prurigo, hyroa vacciniforme, chronic actinic dermatitis, and solar urticaria; 2) photodermatoses which are secondary to exogenous agents, including phototoxic and photoall...

journal_title：Dermatologic therapy

authors： Yashar SS,Lim HW

更新日期：2003-01-01 00:00:00

abstract：:This is the first report of a case of porocarcinoma that was successfully treated with maxacalcitol and imiquimod. ...

journal_title：Dermatologic therapy

authors： Nagasawa T,Hirata A,Niiyama S,Enomoto Y,Fukuda H

更新日期：2019-03-01 00:00:00

abstract：:The purpose of the work was to assess changes in chemerin and irisin levels in women with diagnosed intrahepatic cholestasis of pregnant women treated with ursodeoxycholic acid. The study group consisted of 50 patients with diagnosed and confirmed intrahepatic cholestasis of pregnant women at 24-25 weeks of pregnancy ...

journal_title：Dermatologic therapy

authors： Dąbrowski K,Kierach R,Grabarek BO,Boroń D,Kukla M

更新日期：2020-03-01 00:00:00

abstract：:There are many developmental abnormalities that may appear in the neonate and in infants when critical steps in embryogenesis fail. These steps are often not fatal but can lead to significant morbidity for those patients affected. A logical approach is needed in addressing both the diagnostic and therapeutic issues th...

journal_title：Dermatologic therapy

authors： Farvolden D,Sweeney SM,Wiss K

更新日期：2005-03-01 00:00:00

abstract：:Cutaneous larva migrans (CLM; also called creeping eruption) is a cutaneous ectoparasitosis commonly observed in tropical countries. It is characterized by an erythematous, pruritic, and raised lesion with linear or serpiginous distribution, typically localized at the lower extremities. Oral ivermectin represents the ...

journal_title：Dermatologic therapy

authors： Magri F,Chello C,Pranteda G,Pranteda G

更新日期：2019-05-01 00:00:00

abstract：:Adult-onset Still's disease (AOSD) is a rare, systemic inflammatory disorder of not completely understood etiology. Aberrant activation of the innate immune system and overproduction of several pro-inflammatory mediators are considered a critical component in disease pathogenesis. AOSD still poses a challenge due to t...

journal_title：Dermatologic therapy

authors： Wawrzycki B,Krasowska D,Pietrzak A,Wielosz E,Majdan M,Lotti T

更新日期：2019-09-01 00:00:00