Short- and long-term effects of two emollients on itching and skin restoration in xerotic eczema.

Abstract:

:Pruritus is associated with various skin diseases, dry skin, and with it an impaired skin barrier function. The study objective was to investigate short-term and long-term effects of two emollients on symptoms and skin barrier functions in xerotic eczema. Randomized, double-blind, study enrolling females/males, with bilateral itching. Two emollients, containing lactic acid and refined almond oil with/without polidocanol were administered on left versus right body sides. Itching severity, skin moisture, lipid content, and pH were assessed on Day 1, within 30-120 min after first administration, and on Days 7 and 14, and compared with baseline assessments. Severity of itching decreased 30 min after first administration of both emollients compared with baseline (p < .0001) and reached a maximum reduction of 63% (p < .0001) and 69% (p < .0001) on Day 14. Skin moisture and lipid content increased after first application, and further ameliorated within 14 days of treatment (p < .0001). Both emollients were tolerated well, and only a few adverse events were reported. This study confirmed the clinical efficacy of the two study emollients to substantially reduce itching already after first administration, and restore skin barrier integrity and thus should be considered as therapeutic approach for xerotic eczema.

journal_name

Dermatol Ther

journal_title

Dermatologic therapy

authors

Simon D,Nobbe S,Nägeli M,Barysch M,Kunz M,Borelli S,Hasan-Ali O,Wildi E,Gasser UE

doi

10.1111/dth.12692

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

e12692

issue

6

eissn

1396-0296

issn

1529-8019

journal_volume

31

pub_type

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