Abstract:
:Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous reactions that are medication-induced in most instances. While the clinical manifestations of SJS and TEN are well-defined, the optimal treatment for these disorders is not. Case reports have shown benefit with the use of a variety of agents including tumor necrosis factor-alpha inhibitors and cyclophosphamide, whereas thalidomide was associated with an increased mortality. Plasmapheresis and cyclosporine have also demonstrated efficacy anecdotally, albeit with an even smaller number of cases in the literature. Most of the reporting has focused on the use of systemic corticosteroids and intravenous immunoglobulin (IVIG) for these severe reactions. The majority of studies analyzing the use of IVIG in the treatment of SJS/TEN show a benefit, though more recent series cast doubt upon this conclusion. The results of these studies are summarized in this present review study.
journal_name
Dermatol Therjournal_title
Dermatologic therapyauthors
Worswick S,Cotliar Jdoi
10.1111/j.1529-8019.2011.01396.xsubject
Has Abstractpub_date
2011-03-01 00:00:00pages
207-18issue
2eissn
1396-0296issn
1529-8019journal_volume
24pub_type
杂志文章,评审abstract::Acrodermatitis continua of Hallopeau (ACH) is a chronic, inflammatory, and relapsing disorder characterized by the progressive destruction of fingernails and toenails. This condition is rare, difficult to treat, and often misdiagnosed. Several antipsoriatic treatments have been used, without any therapeutic guideline ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
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journal_title:Dermatologic therapy
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pub_type: 临床试验,杂志文章
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
pub_type: 杂志文章
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journal_title:Dermatologic therapy
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2019-03-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
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更新日期:2006-03-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
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更新日期:2011-11-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
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