Combination therapy of refractory keloid with ultrapulse fractional carbon dioxide (CO2 ) laser and topical triamcinolone in Asians-long-term prevention of keloid recurrence.

Abstract:

:Keloid often recur after treatment, and recent studies in keloid management favor the combination therapy of laser-assisted drug delivery over monotherapy. Unfortunately, the previous researches lack long-term follow-up. In this prospective study, 41 individuals with refractory keloids underwent eight treatment sessions at 4 weeks intervals consisting of ultrapulse fractional carbon dioxide laser (UFCL), followed by postoperative application topical triamcinolone acetonide (40 mg/ml). Four follow-up moments were chosen, with follow-up of 24 months. The effects of combination therapy on scar pliability, thickness, relief, vascularization, surface area, pain, and itchiness were examined by means of the Patient and Observer Scar Assessment Scale (POSAS). 38 patients completed the full 24 months of follow-up after the whole treatment. The results reveal a fast and abiding improvement of keloid scars after the combination therapy. The mean keloid POSAS scores showed a decreasing trend in subsequent times. All POSAS components improved significantly between baseline and 24 months after start of therapy (P < .05). Long-term follow-up results demonstrate that combination keloid therapy using UFCL and tropical triamcinolone has overall significant improvement and low recurrence rate with a long-term stable results.

journal_name

Dermatol Ther

journal_title

Dermatologic therapy

authors

Wang J,Wu J,Xu M,Gao Q,Chen B,Wang F,Song H

doi

10.1111/dth.14359

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

e14359

issue

6

eissn

1396-0296

issn

1529-8019

journal_volume

33

pub_type

杂志文章
  • Poly traditional Chinese medicine formulation prepared with skin moisturizing properties.

    abstract::Many traditional Chinese medicine compositions can moisturize the skin and utilize in cosmetics. Using a combination of Chinese Medicine Materials and guided by Traditional Chinese Medicine principles, this study selected Echinacea purpurea to protect the skin barrier, Dendrobium nobile to clear heat and promote fluid...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.14105

    authors: Meng H,Li J,Dong Y,He Y,Ren H,Liu Y,Qu Z,Zhang W,Zhang L,Bao T,Yi F

    更新日期:2020-11-01 00:00:00

  • Dermatoses of the breast in lactation.

    abstract::Dermatoses of the breast during lactation can be difficult to diagnose because of their overlapping clinical appearances. It is important to properly diagnose and treat nipple dermatitis since it can be a significant source of pain when nursing. Poorly controlled nipple pain in nursing mothers is one of the primary re...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/dth.12071

    authors: Barrett ME,Heller MM,Fullerton Stone H,Murase JE

    更新日期:2013-07-01 00:00:00

  • Apatinib-induced Grade 3 hand-foot syndrome in advanced lung adenocarcinoma successful treated with thalidomide: A case report.

    abstract::Hand-foot syndrome (HFS) is a specific cutaneous toxicity caused by a variety of antitumor drugs. The most common drugs include capecitabine, pegylated liposomal doxorubicin and fluorouracil (PLD), tyrosine kinase inhibitor. It is a dose-limiting cutaneous toxicity of these drugs. We reported an advanced lung adenocar...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.13241

    authors: Ren Y,Li T,Du LY,Qiu Y,Wang SB,Lei KJ,Jia YM

    更新日期:2020-03-01 00:00:00

  • Urticaria mimickers in children.

    abstract::Acute urticaria is a self-limited cutaneous condition marked by transient, erythematous, and pruritic wheals. It is a hypersensitivity response that is often secondary to infection, medications, or food allergies in children. In contrast, the urticarial "mimickers" described in this review article are often seen in th...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/dth.12103

    authors: Mathur AN,Mathes EF

    更新日期:2013-11-01 00:00:00

  • Visceral leishmaniasis with cutaneous symptoms in a patient treated with infliximab followed by fatal consequences.

    abstract::Leishmaniasis is an infectious disease caused by parasitic flagellates of the genus Leishmania. The authors present a case of 44-year-old man with Crohn's disease treated successfully with infliximab. This case report shows rare visceral leishmaniasis with cutaneous symptoms in an immunocompromised patient. Skin manif...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.12083

    authors: Juzlova K,Votrubova J,Kacerovska D,Lukas M,Bortlik M,Rohacova H,Nohynkova E,Vojackova N,Fialova J,Hercogova J

    更新日期:2014-05-01 00:00:00

  • Therapeutic options for chronic hand dermatitis.

    abstract::Hand dermatitis is a common skin condition that often has a chronic and/or relapsing clinical course. Several clinical forms of hand dermatitis have been described, including contact (i.e., allergic and irritant), hyperkeratotic (i.e., psoriasiform or tylotic), frictional, nummular, atopic, pompholyx (i.e., dyshidrosi...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1396-0296.2004.04025.x

    authors: Warshaw EM

    更新日期:2004-01-01 00:00:00

  • Treatment of patch-stage mycosis fungoides with topical corticosteroids.

    abstract::Experience at the University of California, San Francisco (UCSF), in the management of patch-stage mycosis fungoides (MF) with topical, predominantly high-potency, corticosteroids is reviewed. The technique of applications is discussed in detail. Approximately 200 patients have been treated. The results are very favor...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1396-0296.2003.01639.x

    authors: Zackheim HS

    更新日期:2003-01-01 00:00:00

  • Eccrine porocarcinoma.

    abstract::Eccrine porocarcinoma (EPC) is a rare cutaneous neoplasm that grows slowly over a long period of time but often experiences an accelerated growth phase. This malignant tumor may arise denovo or evolve from a pre-existing benign eccrine poroma. Histologic evaluation demonstrates anaplastic cells involving the epidermis...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1529-8019.2008.00243.x

    authors: Brown CW Jr,Dy LC

    更新日期:2008-11-01 00:00:00

  • Adverse electrocardiographic effects of rituximab infusion in pemphigus patients.

    abstract::Pemphigus encompasses a group of chronic autoimmune blistering diseases of the skin and/or mucosa. Rituximab (RTX) has shown promising efficacy for the treatment of pemphigus in the past decade. Considering potential cardiac side effects, this study was conducted to assess the effects of RTX on electrocardiogram (ECG)...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.14299

    authors: Aidi S,Daneshpazhooh M,Eslami M,Azizpour A,Toosi R,Mollazadeh R

    更新日期:2020-11-01 00:00:00

  • A patient with delusional infestation by proxy: Issues for vulnerable adults.

    abstract::A 57-year-old Caucasian female presented to our clinic with her 23-year-old son, who was profoundly autistic. Our patient was convinced that her son had an infestation with fibers and believed that he had developed the condition as a young child. She described the symptoms of the infestation in her son's skin on his b...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.12724

    authors: Hussain K,Gkini MA,Taylor R,Shinhmar S,Bewley A

    更新日期:2018-11-01 00:00:00

  • The impact of COVID-19 pandemic on the management of patients with chronic urticaria: An observational two-center study from Turkey.

    abstract::The Coronavirus Disease 2019 (COVID-19) outbreak significantly affected the clinical practice in hospitals and the management of many diseases. The aim of this study was to evaluate the effect of pandemic-related factors on the severity and course of chronic urticaria (CU). A total of 194 CU patients who were on regul...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.14652

    authors: Erdem Y,Polat Ekinci A,Altunay IK,Sivaz O,Inal S,Gokalp MO,Pehlivan G,Özkaya E

    更新日期:2020-12-10 00:00:00

  • The future: critical knowledge about anti-itch therapy.

    abstract::Itch is an extremely frequent and enervating symptom of many diseases. Current anti-itch therapy, which is based almost exclusively on an "immunocentric" viewpoint, is often unsatisfactory. Recent studies show that this symptom is in fact the result of a complex interplay among skin, nervous system, endocrine system, ...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1529-8019.2005.00030.x

    authors: Guarneri C,Terranova M,Terranova G,Guarneri F

    更新日期:2005-07-01 00:00:00

  • Self-administered daylight-activated photodynamic therapy for the treatment of hand eczema: A prospective proof-of-concept study.

    abstract::Photodynamic therapy (PDT), traditionally used in patients with nonmelanoma skin cancer, has been found to be effective for various inflammatory skin conditions. Daylight-activated PDT (DL-PDT), in which the sun serves as the light source, is substantially less painful than conventional PDT. This study aimed to determ...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.14329

    authors: Kremer N,Sherman S,Lapidoth M,Enk CD,Leshem YA,Mimouni T,Dudkiewicz D,Hodak E,Levi A

    更新日期:2020-11-01 00:00:00

  • Morgellons disease?

    abstract::Morgellons disease, a pattern of dermatologic symptoms very similar, if not identical, to those of delusions of parasitosis, was first described many centuries ago, but has recently been given much attention on the internet and in the mass media. The present authors present a history of Morgellons disease, in addition...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/j.1529-8019.2008.00164.x

    authors: Accordino RE,Engler D,Ginsburg IH,Koo J

    更新日期:2008-01-01 00:00:00

  • Use of Becaplermin for nondiabetic ulcers: pyoderma gangrenosum and calciphylaxis.

    abstract::Large difficult to heal ulcers of various etiologies carry a high morbidity and mortality rate. Becaplermin is a recombinant platelet-derived growth factor approved for treatment of diabetic ulcers. In this two-case series, we report the use of becaplermin in the treatment of ulcers due to (i) calciphylaxis, an often ...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.12318

    authors: Twu O,Mednik S,Scumpia P,Doaty S,Worswick S

    更新日期:2016-03-01 00:00:00

  • Oral zinc therapy for zinc deficiency-related telogen effluvium.

    abstract::Zinc is crucial for maintaining human body homeostasis and is one of the major components of hormones, signal molecules, and enzymes. Zinc deficiency is caused by insufficient uptake of zinc from food, or caused by malabsorption syndromes, increased gastrointestinal and urinary losses, and administration of various me...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/j.1529-8019.2012.01443.x

    authors: Karashima T,Tsuruta D,Hamada T,Ono F,Ishii N,Abe T,Ohyama B,Nakama T,Dainichi T,Hashimoto T

    更新日期:2012-03-01 00:00:00

  • Cutaneous sıde-effects of the potential COVID-19 drugs.

    abstract::COVID-19 disease is a highly contagious and particularly popular problem in all countries. A variety of repurposed drugs and investigational drugs such as remdesivir, chloroquine, hydroxychloroquine, ritonavir, lopinavir, interferon-beta, and other potential drugs have been studied for COVID19 treatment. We reviewed t...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/dth.13476

    authors: Türsen Ü,Türsen B,Lotti T

    更新日期:2020-07-01 00:00:00

  • Insights into laser safety considerations during COVID 19 pandemic.

    abstract::The World Health Organization has recently defined the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections as a pandemic. The infection, which may cause a potentially very severe respiratory disease, now called coronavirus disease 2019 (COVID-19), has airborne transmission via droplets while less a...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.13777

    authors: Elsaie ML,Nada HA

    更新日期:2020-09-01 00:00:00

  • Investigation of hearing and outer hair cell function of the cochlea in patients with vitiligo.

    abstract::Vitiligo is a systemic disease that affects not only the skin but also other areas that contain melanocytes, such as the inner ear. Studies of the effect of vitiligo on hearing loss have shown inconsistent results, and it is not clear which parameters related to the disease affect hearing. The aim of this study was to...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.13724

    authors: Ertugrul G,Ertugrul S,Soylemez E

    更新日期:2020-07-01 00:00:00

  • Unlocking the mystery of persistent skin ulcers in a young man and successful treatment with a simple regimen.

    abstract::Despite the high prevalence of pulmonary tuberculosis worldwide, extrapulmonary tuberculosis especially cutaneous and osteoarticular tuberculosis occurs rarely, both of which are often difficult to be recognized since their symptoms mimic those of many other cutaneous and osteoarticular diseases. Here, we present a ra...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.12600

    authors: Li Z,Wang S,Chen X,Ming X,Peng L,Li W

    更新日期:2018-07-01 00:00:00

  • Soft-tissue augmentation with hyaluronic acid and calcium hydroxyl apatite fillers.

    abstract::Soft-tissue augmentation with hyaluronic acid and calcium hydroxyl apatite are among the most widely used minimally invasive cosmetic treatments for the correction of contour deficiencies and wrinkles of the face without the risk, recovery time, and expense of a major surgery. Training and experience in the art and sc...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/j.1529-8019.2010.01380.x

    authors: Redbord KP,Busso M,Hanke CW

    更新日期:2011-01-01 00:00:00

  • Effect of ursodeoxycholic acid therapy due to pregnant intrahepatic cholestasis on chemerin and irisin levels.

    abstract::The purpose of the work was to assess changes in chemerin and irisin levels in women with diagnosed intrahepatic cholestasis of pregnant women treated with ursodeoxycholic acid. The study group consisted of 50 patients with diagnosed and confirmed intrahepatic cholestasis of pregnant women at 24-25 weeks of pregnancy ...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.13272

    authors: Dąbrowski K,Kierach R,Grabarek BO,Boroń D,Kukla M

    更新日期:2020-03-01 00:00:00

  • Efficacy of electrochemotherapy for eruptive legs keratoacanthomas.

    abstract::Generalized eruptive keratoacanthoma, is considered a serious condition because the eruptions are diffuse, persistent, and recurrent. Constant pruritus, visceral neoplasms, and unsatisfactory response to treatment are ominous prognostic factors. Even if skin cancers are usually well controlled with surgical and/or rad...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.12374

    authors: Ribero S,Balagna E,Sportoletti Baduel E,Picciotto F,Sanlorenzo M,Fierro MT,Quaglino P,Macripo G

    更新日期:2016-09-01 00:00:00

  • Dermoscopic characterization of guttate psoriasis, pityriasis rosea, and pityriasis lichenoides chronica in dark skin phototypes: An observational study.

    abstract::Dermoscopy as a diagnostic tool is attaining impetus in inflammatory dermatoses with the cumulative description of characteristic findings in most dermatoses obviating at times the need of biopsy. In this retrospective observational study, 20 histopathology confirmed cases each of pityriasis rosea (PR), guttate psoria...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.14631

    authors: Jindal R,Chauhan P,Sethi S

    更新日期:2020-12-05 00:00:00

  • Evaluation of dermatology consultations in the era of COVID-19.

    abstract::It has been reported that dermatology practices may be a vector for SARS-CoV-2 transmission and elective cases should be postponed during the pandemic period. In this context, studies on the change of patient profile in Dermatology outpatient clinic have been conducted. However, there was no study in the literature ab...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.13642

    authors: Temiz SA,Dursun R,Daye M,Ataseven A

    更新日期:2020-09-01 00:00:00

  • Psychotropic drugs in dermatology: A dermatologist's approach and choice of medications.

    abstract::Psychiatric symptoms in dermatology practice are increasingly being recognized. The use of psychiatric medications by dermatologist is dealt with caution and uncertainty in several psychodermatological conditions. Several skin conditions are associated with anxiety, depression, and obsessive-compulsive symptoms. Some ...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/dth.13385

    authors: Jafferany M,Stamu-O'Brien C,Mkhoyan R,Patel A

    更新日期:2020-05-01 00:00:00

  • Methotrexate vs secukinumab safety in psoriasis patients with metabolic syndrome.

    abstract::The safety of methotrexate in psoriasis patients with metabolic syndrome could be argued because of increased risk of liver toxicity. The aim of the study was to investigate the safety of methotrexate compared with secukinumab in psoriasis patients with metabolic syndrome. A controlled, open trial in psoriasis patient...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.14281

    authors: Gisondi P,Bellinato F,Bruni M,De Angelis G,Girolomoni G

    更新日期:2020-11-01 00:00:00

  • Biologics in dermatology: What does the future hold?

    abstract::As the first dermatological biological treatment, infliximab was first used in the treatment of psoriasis in 2001. Since that time many biological agents have come into use for dermatological diseases and developments in this area are still ongoing. The most important feature of biological treatments is that the treat...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.12932

    authors: Yavuz C

    更新日期:2019-07-01 00:00:00

  • Safety and efficacy of single pass vs multipass emission with 755 alexandrite laser for all-skin-type hair removal: A pilot study.

    abstract::Lasers are considered the most efficient methods for hair reduction. The goal of these devices is to provide long-term effects without adverse reactions. This is a randomized split-body controlled study on body hair removal and pseudofolliculitis (PFC) treatment, comparing the standard single pass (SP) emission with t...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.14001

    authors: Bonan P,Troiano M,Verdelli A

    更新日期:2020-11-01 00:00:00

  • TNF- alpha inhibitors.

    abstract::Tumor necrosis-alpha (TNF-alpha) has been implicated in many forms of inflammation and is an end-stage product of the inflammatory cytokine cascade. It is an inducer of inflammation and is involved in many cutaneous and systemic inflammatory diseases. The development of agents that block the effects of TNF-alpha has a...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1529-8019.2007.00138.x

    authors: Jackson JM

    更新日期:2007-07-01 00:00:00