Abstract:
:Tumor necrosis-alpha (TNF-alpha) has been implicated in many forms of inflammation and is an end-stage product of the inflammatory cytokine cascade. It is an inducer of inflammation and is involved in many cutaneous and systemic inflammatory diseases. The development of agents that block the effects of TNF-alpha has aided in the treatment of many of these diseases. This article will briefly discuss the production, structure, and administration of the TNF-alpha inhibitors. There will be a focus on the mechanism of action of each of the TNF-alpha inhibitors as well as their benefit in their FDA approved and non FDA approved dermatologic conditions. The side effect profile and monitoring recommendations for these agents will also be discussed.
journal_name
Dermatol Therjournal_title
Dermatologic therapyauthors
Jackson JMdoi
10.1111/j.1529-8019.2007.00138.xsubject
Has Abstractpub_date
2007-07-01 00:00:00pages
251-64issue
4eissn
1396-0296issn
1529-8019pii
DTH138journal_volume
20pub_type
杂志文章,评审abstract::Past studies have reported associations between psoriasis, metabolic syndrome, and atherosclerotic cardiovascular disease. According to studies, N-terminal pro B-type natriuretic peptide (NT-proBNP) is a useful screening test for cardiac disease. We examined the serum NT-proBNP level in patients with psoriasis and com...
journal_title:Dermatologic therapy
pub_type: 信件
doi:10.1111/dth.12865
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:There are conflicting results in the literature regarding the frequency of allergic diseases in COVID-19 patients. The effect of having an allergic disease on COVID-19 disease severity has been little studied. In this study, we tried to determine the frequency of allergic diseases in COVID-19 patients and th...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14581
更新日期:2020-11-25 00:00:00
abstract::Pigmented lesions represent an enormous range of conditions, from benign to malignant tumors, and from infectious to post-inflammatory. Pigmented lesions are much less easily diagnosed on anogenital skin, and clinicians should have a low threshold for biopsy confirmation of diseases not classic in appearance. ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/j.1529-8019.2010.01349.x
更新日期:2010-09-01 00:00:00
abstract::This is the first report of a case of porocarcinoma that was successfully treated with maxacalcitol and imiquimod. ...
journal_title:Dermatologic therapy
pub_type: 信件
doi:10.1111/dth.12830
更新日期:2019-03-01 00:00:00
abstract::Omalizumab is a monoclonal antibody, targeting Fc receptor of IgE, approved for the treatment of allergic asthma and chronic spontaneous urticaria. Its utility in atopic dermatitis appears controversial from data in literature since the molecule is well tolerated but it seems less effective than other medications used...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13519
更新日期:2020-07-01 00:00:00
abstract::Filiform warts are commonly treated with surgical removal or cryotherapy, yet such treatment modalities may result in complications for darker skin types. We report a man successfully treated for more than 50 filiform facial warts using a combination of 5-fluorouracil 5% and salicylic acid 20%. ...
journal_title:Dermatologic therapy
pub_type: 信件
doi:10.1111/dth.13235
更新日期:2020-03-01 00:00:00
abstract::In the past decade, the expanded use of targeted anticancer drugs has significantly prolonged survival in patients treated for a variety of cancers. Despite their increased specificity, agents such as epidermal growth factor receptor inhibitors (EGFRIs), BRAF inhibitors, and targeted immunotherapies have commonly been...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.12027
更新日期:2013-03-01 00:00:00
abstract::Reflectance confocal microscopy (RCM) enables the noninvasive in vivo imaging of the skin with a horizontal axis and a cellular-level resolution allowing the study of the skin from superficial layers to papillary dermis. It has arisen an important tool in the study of tumors and specially an important role in the char...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/j.1529-8019.2012.01495.x
更新日期:2012-09-01 00:00:00
abstract::Many traditional Chinese medicine compositions can moisturize the skin and utilize in cosmetics. Using a combination of Chinese Medicine Materials and guided by Traditional Chinese Medicine principles, this study selected Echinacea purpurea to protect the skin barrier, Dendrobium nobile to clear heat and promote fluid...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14105
更新日期:2020-11-01 00:00:00
abstract::Basal cell carcinoma (BCC) is the most common malignancy in Caucasians, and its incidence is increasing. Most BCCs are treated surgically, nevertheless surgery is not an effective treatment for locally advanced or metastatic BCC. Alterations in hedgehog signaling pathway, a key regulator of cell growth and differentia...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13108
更新日期:2019-11-01 00:00:00
abstract::Performing an accurate oral examination is an integral part of a complete dermatological evaluation. As dermatologists, we are frequently asked to assess and treat numerous oral pathologies, which include, but are not limited to, normal variants, infections, ulcers, granulomas, lymphomas, as well as primary and metast...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/j.1529-8019.2010.01318.x
更新日期:2010-05-01 00:00:00
abstract::Lasers and other light sources are popular treatment options for facial rejuvenation in recent years. In this study, we aimed to compare the efficacy and safety of fractional radiofrequency (RF) and fractional Erbium: YAG (Er:YAG) laser for facial and neck skin wrinkles, objectively. Three hundred and thirty-three pat...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13054
更新日期:2019-09-01 00:00:00
abstract::Ingrown nail is a common problem seen in the dermatology clinics. The aim of this study is to compare the wedge resection method and chemical matricectomy with NaOH in terms of operation time, postoperative pain severity, postoperative drainage, recurrence rates, recovery time, and the effects of these two methods on ...
journal_title:Dermatologic therapy
pub_type: 杂志文章,随机对照试验
doi:10.1111/dth.12677
更新日期:2018-09-01 00:00:00
abstract::Pemphigus vulgaris (PV), an autoimmune blistering disease is treated with immunosuppressive medications. As the immunosuppressive effect of rituximab, the first-line therapy of PV, lasts more than 6 months, many concerns have raised due to the ongoing novel coronavirus disease (COVID-19) pandemic. With this background...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.14405
更新日期:2020-10-13 00:00:00
abstract::Tinea pedis affects the life quality distinctly and patients those with a prolonged disease often resort to non-medical methods. We sought to evaluate patients' knowledge about tinea pedis and approaches to the non-pharmacological agents. A cross-sectional study was conducted on 152 patients with tinea pedis who answe...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14041
更新日期:2020-11-01 00:00:00
abstract::Scleredema is a deposition disorder which presents as diffuse, symmetric, non-pitting skin induration from dermal deposits of glycosaminoglycans ("mucins"). It classically affects the upper back and posterior neck, often causing skin tightness and decreased range of motion. In most patients the clinical course is chro...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.12504
更新日期:2017-07-01 00:00:00
abstract::Nucleosomes are typically located intracellularly, and extracellular levels of nucleosomes indicated the degree of cell death. We postulated aberrant nucleosomes expression in dermatomyositis (DM) and polymyositis (PM). To assess the aberrant expression of circulating nucleosomes in DM and polymyositis. 76 consecutive...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14460
更新日期:2020-11-01 00:00:00
abstract::Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, there has been an open debate on the impact of biological drugs used in the treatment of psoriasis. To define whether patients under treatment with biologics suffer from increased morbidity and mortality from COVID-19, compared to psoriatic patients ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14516
更新日期:2020-11-01 00:00:00
abstract::Psoriasis has been reported to be rare in people with skin of color. However, the actual prevalence is probably underestimated by the lack of wide epidemiological studies. The aim of the study is to present our experience in Tigray, Ethiopia, focusing on the issues related to diagnosis, clinical features and therapies...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14718
更新日期:2020-12-27 00:00:00
abstract::Infection-induced panniculitis may result from a number of microbes including bacteria, fungi, and parasites. Viruses have also been implicated as a cause. This type of panniculitis can occur as a primary infection by direct inoculation of infectious microorganisms into the subcutaneous tissue, or secondarily via micr...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2010.01333.x
更新日期:2010-07-01 00:00:00
abstract::Psoriasis is a chronic inflammatory condition that often requires life-long treatment. Conventional therapies have not fully met the needs of psoriatic patients, because of limited efficacy, adverse effects with cumulative use, and patient inconvenience. In the past decade, biologic immunotherapies have become accepte...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2009.01259.x
更新日期:2009-09-01 00:00:00
abstract::Ungual melanomas are considered rare, being difficult to diagnose, and having a poor prognosis. The aim of the present study was to discuss the epidemiology, potential causes, treatment options, and outcome of ungual melanomas. In contrast to assumptions in many articles, ungual melanomas are not rare when calculated ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/j.1529-8019.2012.01515.x
更新日期:2012-11-01 00:00:00
abstract::The Dangguikushen (DGKS) pill is a proprietary traditional Chinese medicine that has shown superior efficacy in the treatment of acne vulgaris for many years. A network pharmacology-based analysis was performed to explore the potential anti-acne compounds, core therapeutic targets, and the main pathways, involved in t...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14061
更新日期:2020-11-01 00:00:00
abstract::Male cosmetic patients represent a growing population of individuals who can substantially benefit from well-chosen esthetic interventions. Understanding some of the unique aspects of the male psyche can result in more effective recruitment of male cosmetic patients and aid the clinician in helping these patients to c...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2007.00152.x
更新日期:2007-11-01 00:00:00
abstract::Pruritus is associated with various skin diseases, dry skin, and with it an impaired skin barrier function. The study objective was to investigate short-term and long-term effects of two emollients on symptoms and skin barrier functions in xerotic eczema. Randomized, double-blind, study enrolling females/males, with b...
journal_title:Dermatologic therapy
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/dth.12692
更新日期:2018-11-01 00:00:00
abstract::Diphenylcyclopropenone (DPCP) immunotherapy has been shown to be efficacious for the treatment of warts, especially periungual warts for which destructive techniques are limited. However, factors affecting the duration of treatment of periungual warts have not been studied. A total of 61 patients with periungual warts...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12312
更新日期:2016-03-01 00:00:00
abstract::Severe acute respiratory syndrome-corona virus-2, which causes coronavirus disease 2019 (COVID-19), is highly contagious and a particularly popular problem in all around the World and also in all departments of every hospital. In order to protect the well-being of health care providers while providing a sufficient wor...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13438
更新日期:2020-07-01 00:00:00
abstract::In view of the new viral COVID-19 pandemic, the fungal Candida auris epidemic still in progress worldwide highlights non-Candida albicans candidal infections. We describe an immunocompetent woman with a cutaneous manifestation of Candida parasilopsis fungemia, a prominent eschar, which proved to be the nidus for the c...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13481
更新日期:2020-07-01 00:00:00
abstract::Fractional ablative carbon dioxide laser resurfacing is a frontline treatment for acne scars. It creates multiple microscopic treatment zones to accelerate the collagen formation and the healing process of reepithelialization, according the principle of fractional photothermolysis. At present, the fractional CO2 laser...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.13084
更新日期:2019-11-01 00:00:00
abstract::Psoriatic patients with latent tuberculosis infection (LTBI) need a prophylaxis before starting a treatment with biological drugs. The aim of this study is to investigate the safety and efficacy of prophylaxis of LTBI in psoriatic patients receiving long-term biological drugs. The study included 56 patients (42 male a...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12503
更新日期:2017-09-01 00:00:00