Pruritus to anticancer agents targeting the EGFR, BRAF, and CTLA-4.

Abstract:

:In the past decade, the expanded use of targeted anticancer drugs has significantly prolonged survival in patients treated for a variety of cancers. Despite their increased specificity, agents such as epidermal growth factor receptor inhibitors (EGFRIs), BRAF inhibitors, and targeted immunotherapies have commonly been associated with a number of dermatologic adverse events, often necessitating treatment modifications and negatively impacting patients' quality of life. Although toxicities such as rash and xerosis are frequently discussed, symptomatic pruritus, or itch, has emerged as an important, and frequently neglected, event. The present study reviews the incidence and clinical presentation of pruritus with the EFGRIs, and with two novel anti-melanoma drugs, vemurafenib and ipilimumab, with a focus on the putative underlying pathophysiology, and current management strategies.

journal_name

Dermatol Ther

journal_title

Dermatologic therapy

authors

Fischer A,Rosen AC,Ensslin CJ,Wu S,Lacouture ME

doi

10.1111/dth.12027

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

135-48

issue

2

eissn

1396-0296

issn

1529-8019

journal_volume

26

pub_type

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