Apatinib-induced Grade 3 hand-foot syndrome in advanced lung adenocarcinoma successful treated with thalidomide: A case report.

Abstract:

:Hand-foot syndrome (HFS) is a specific cutaneous toxicity caused by a variety of antitumor drugs. The most common drugs include capecitabine, pegylated liposomal doxorubicin and fluorouracil (PLD), tyrosine kinase inhibitor. It is a dose-limiting cutaneous toxicity of these drugs. We reported an advanced lung adenocarcinoma female patient, who developed a Grade 3 HFS after a third-line treatment with apatinib of 250 mg for 10 days, the patient developed intolerable pain with pruritus. Large erythema on the skin of the hand, with local ulceratio, exudation, and desquamation of cutaneous lesions. After treatment with 100 mg of thalidomide every night for 1 week, the patient's HFS was significantly relieved, and the duration of the remission was about 2 months, which not only significantly improved the patient's quality of life, but also maintained the antitumor strength.

journal_name

Dermatol Ther

journal_title

Dermatologic therapy

authors

Ren Y,Li T,Du LY,Qiu Y,Wang SB,Lei KJ,Jia YM

doi

10.1111/dth.13241

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

e13241

issue

2

eissn

1396-0296

issn

1529-8019

journal_volume

33

pub_type

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