Abstract:
:Melasma is a human melanogenesis dysfunction that results in localized, chronic acquired hyperpigmentation of the skin. It has a significant impact on appearance, causing psychosocial and emotional distress, and reducing the quality of life of the affected patients. Tranexamic acid (TA) is a plasmin inhibitor used to prevent abnormal fibrinolysis to reduce blood loss and exerts its effect by reversibly blocking lysine binding sites on plasminogen molecules, thus inhibiting plasminogen activator (PA) from converting plasminogen to plasmin. As plasminogen also exists in human epidermal basal cells and cultured human keratinocyte are known to produce PA, there is basic rationale that TA will affect keratinocyte function and interaction. A thorough literature review indicates that while TA is used through various route of administration including oral, topical, and intradermal injection and as adjutant therapy with laser to treat melasma, its efficacy is not established adequately. Further studies are needed to clarify the role of TA in treatment of melasma.
journal_name
Dermatol Therjournal_title
Dermatologic therapyauthors
Taraz M,Niknam S,Ehsani AHdoi
10.1111/dth.12465subject
Has Abstractpub_date
2017-05-01 00:00:00issue
3eissn
1396-0296issn
1529-8019journal_volume
30pub_type
杂志文章,评审abstract::Jarisch-Herxheimer reaction (JHR) is an acute and self-limited condition, which commonly occurs after treatment for spirochetal infections. Probably, it corresponds to a transient immunological reaction to endotoxin-like products released from the microorganism during the therapy. For this reason, JHR may be associate...
journal_title:Dermatologic therapy
pub_type: 杂志文章
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
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doi:10.1111/dth.12370
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
pub_type: 杂志文章
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更新日期:2016-09-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12452
更新日期:2017-03-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章,随机对照试验
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更新日期:2018-09-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13686
更新日期:2020-09-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14041
更新日期:2020-11-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12056
更新日期:2014-03-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2012.01501.x
更新日期:2012-05-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13898
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journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
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abstract:BACKGROUND:There are conflicting results in the literature regarding the frequency of allergic diseases in COVID-19 patients. The effect of having an allergic disease on COVID-19 disease severity has been little studied. In this study, we tried to determine the frequency of allergic diseases in COVID-19 patients and th...
journal_title:Dermatologic therapy
pub_type: 杂志文章
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journal_title:Dermatologic therapy
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pub_type: 信件
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
pub_type: 杂志文章
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journal_title:Dermatologic therapy
pub_type: 杂志文章
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journal_title:Dermatologic therapy
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pub_type: 杂志文章,评审
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