Abstract:
:During the past 20 years, tremendous progress has been made in our understanding of the molecular basis of many genetic skin conditions. The translation of these laboratory findings into effective therapies for affected individuals has been slow, however, in large part due to the risk of carcinogenesis from random viral genomic integration and the lack of efficacy of topically applied genetic material and most proteins. As intervention at the gene level still appears remote for most genetic disorders, increased knowledge about the cellular and biochemical pathogenesis of disease allows specific targeting of pathways with existing and/or novel drugs and molecules. In contrast to the requirement for personalization of most gene-based approaches, pathogenesis-based therapy is pathway specific, and in theory, it should have broader applicability. In this chapter, we provide an overview of the pathoetiology of the various types of ichthyoses and demonstrate how a pathogenesis-based approach can potentially lead to innovative treatments for these conditions. Notably, this strategy has been successfully validated for the treatment of the rare X-linked dominant condition, CHILD syndrome, in which topical applications of cholesterol and lovastatin together to affected skin resulted in marked improvement of the skin phenotype.
journal_name
Dermatol Therjournal_title
Dermatologic therapyauthors
Lai-Cheong JE,Elias PM,Paller ASdoi
10.1111/j.1529-8019.2012.01528.xsubject
Has Abstractpub_date
2013-01-01 00:00:00pages
46-54issue
1eissn
1396-0296issn
1529-8019journal_volume
26pub_type
杂志文章,评审abstract::Solid organ transplant recipients are at a significantly increased risk of developing skin cancer. Both systemic and topical retinoids are useful for chemosuppression of skin cancer in this patient population. These drugs can reduce both the present extent and the future development of premalignant and malignant skin ...
journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
pub_type: 杂志文章
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journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
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journal_title:Dermatologic therapy
pub_type: 信件
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journal_title:Dermatologic therapy
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更新日期:2021-01-24 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
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journal_title:Dermatologic therapy
pub_type: 杂志文章
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journal_title:Dermatologic therapy
pub_type: 信件
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更新日期:2019-05-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
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更新日期:2020-11-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章,随机对照试验
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更新日期:2018-09-01 00:00:00
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
pub_type: 临床试验,杂志文章
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
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