The use of oral antibiotics in treating acne vulgaris: a new approach.

Abstract:

:Although acne is not an infectious disease, oral antibiotics have remained a mainstay of treatment over the last 40 years. The anti-inflammatory properties of oral antibiotics, particularly the tetracyclines, are efficacious in treating inflammatory acne lesions. Common prescribing practices in Dermatology exert significant selection pressure on bacteria, contributing to the development of antibiotic resistance. Antibiotic use for acne not only promotes resistance in Propionibacterium acnes, but also affects other host bacteria with pathogenic potential. This review will summarize the commonly used treatments for acne vulgaris, and how they should be combined as rational treatment. The indications for using oral antibiotics in acne will be highlighted. Strategies described in the literature to conserve the utility of oral antibiotics will be summarized. These include limiting the duration of antibiotic therapy, concomitant use of a topical non-antibiotic agent, use of subantimicrobial dose doxycycline, and the introduction of topical dapsone.

journal_name

Dermatol Ther

journal_title

Dermatologic therapy

authors

Farrah G,Tan E

doi

10.1111/dth.12370

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

377-384

issue

5

eissn

1396-0296

issn

1529-8019

journal_volume

29

pub_type

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