Breaking paradigms in the treatment of psoriasis: Use of botulinum toxin for the treatment of plaque psoriasis.

Abstract:

:Some studies have demonstrated that neurotransmitters are involved in the pathogenesis of numerous skin conditions, including psoriasis, addressing the close correlation between the skin and the central nervous system. There are reports showing psoriasis improvement after peripheral nervous system injury. In addition, botulinum toxin has been reported as a treatment for several diseases, including psoriasis. This is a proof-of-concept study of botulinum toxin and psoriasis, involving eight patients with stable and recalcitrant plaques of psoriasis vulgaris. The lesions were 5 cm2 at the maximum. Botulinum toxin Dysport (Ipsen Biopharm, Wrexham, UK), 5 units per cm2 , was administered in one subcutaneous application. Patients were then evaluated at 2 and 4 weeks after treatment. Our results indicated a substantial improvement in all patients, 4 weeks after treatment, with no significant side effects. Our preliminary conclusion is that botulinum toxin represents a novel mechanism for interfering with the immunopathogenesis of psoriasis and improving the quality of life of our patients.

journal_name

Dermatol Ther

journal_title

Dermatologic therapy

authors

González C,Franco M,Londoño A,Valenzuela F

doi

10.1111/dth.14319

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

e14319

issue

6

eissn

1396-0296

issn

1529-8019

journal_volume

33

pub_type

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