Successful treatment of psoriatic crumbly nails with ustekinumab.

Abstract:

:Nail involvement can place a significant burden on patients as a result of functional damage and psychosocial problems, leading to major repercussions on the quality of life. There is strong evidence that nail psoriasis can often be difficult to treat. We report a 69-year-old man with severe onychodystrophy, onycholysis, and pain in the hands; he had been previously treated with topical and systemic traditional therapies without satisfactory response. The patient showed multiple severe psoriatic crumbly nails (nail psoriasis severity index [NAPSI] score of 69) and started ustekinumab treatment at standard dosage of 45 mg fl.s.c. After 24 weeks, both nail matrix and nail bed disease showed marked improvement and the patient continued therapy with ustekinumab (NAPSI 0 at week 104). At week 136 (September 2015), the patient had been complaining of hands pain (visual analogue scale pain: 80) and ultrasonographic (US) evaluations found a synovial proliferation with effusion on metacarpophalangeal joints. The patient continued therapy with ustekinumab, adding methotrexate 10 mg fl.s.c/week. In November 2016, the patient showed a remission of symptoms; clinical and US evaluations did not find signs of synovitis. Methotrexate treatment was suspended and currently the patient reached more than 4 years of ustekinumab treatment without sign and symptoms of synovitis.

journal_name

Dermatol Ther

journal_title

Dermatologic therapy

authors

Galluzzo M,D'Adamio S,Chimenti MS,Teoli M,Bianchi L,Talamonti M

doi

10.1111/dth.12914

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

e12914

issue

3

eissn

1396-0296

issn

1529-8019

journal_volume

32

pub_type

杂志文章
  • Topical cidofovir for plantar warts.

    abstract::Plantar warts are a common reason for dermatological consultations and their treatment can occasionally be a challenge. Plantar warts are benign lesions produced by the human papillomavirus (HPV) that often fail to respond to habitual treatment. Cidofovir is a potent antiviral drug that acts competitively, inhibiting ...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.12061

    authors: Padilla España L,Del Boz J,Fernández Morano T,Arenas Villafranca J,de Troya Martín M

    更新日期:2014-03-01 00:00:00

  • Aberrant expression of cell-free nucleosomes in dermatomyositis/polymyositis.

    abstract::Nucleosomes are typically located intracellularly, and extracellular levels of nucleosomes indicated the degree of cell death. We postulated aberrant nucleosomes expression in dermatomyositis (DM) and polymyositis (PM). To assess the aberrant expression of circulating nucleosomes in DM and polymyositis. 76 consecutive...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.14460

    authors: Zhong D,Wu C,Bai J,Zhao J,Xu D,Li M,Wang Q,Wang F,Zeng X

    更新日期:2020-11-01 00:00:00

  • A refined surgical treatment modality for bromhidrosis: Subcutaneous scissor with micropore.

    abstract::Axillary bromhidrosis has a strong negative effect on one's social life. A high success rate and few complications are criteria for a surgical treatment. The objective of this study was to evaluate a new surgical treatment modality for bromhidrosis: subcutaneous scissor with micropore. Twenty patients with bromhidrosi...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.12484

    authors: Dai Y,Xu AE,He J

    更新日期:2017-05-01 00:00:00

  • Angiotensin-converting-enzyme inhibitors and angiotensin II receptor blockers induced pemphigus: A case series and literature review.

    abstract::Pemphigus is a group of autoimmune diseases characterized by the formation of erosions and/or flaccid bullae of the skin and/or mucosae. The definition "drug-induced pemphigus" has been coined to indicate cases of pemphigus with clinical, histological and immunopathologic features similar to those of the idiopathic di...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/dth.12748

    authors: Palleria C,Bennardo L,Dastoli S,Iannone LF,Silvestri M,Manti A,Nisticò SP,Russo E,De Sarro G

    更新日期:2019-01-01 00:00:00

  • Drug reaction with eosinophilia and systemic symptoms: A single center descriptive observational study.

    abstract::Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe adverse cutaneous drug reaction with mortality up to 10%. It is a rare condition with risk varying between 1 in 1000 and 1 in 10 000 drug exposures. The aim of the study was to describe clinical features, management and drugs responsible for cau...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.14670

    authors: Sandhu S,Neema S,Vashisht D,Venugopal R,Sengupta P,Radhakrishnan S

    更新日期:2020-12-14 00:00:00

  • Topical application of a linoleic acid-ceramide containing moisturizer exhibit therapeutic and preventive benefits for psoriasis vulgaris: a randomized controlled trial.

    abstract::Psoriasis is a chronic skin inflammatory disorder with frequent relapse. Ceramides and their key enzymes are deficient in the lesions, resulting in impaired epidermal permeability barrier, which correlates with disease severity. We evaluated the efficacy of linoleic acid-ceramide moisturizer (LA-Cer) as an adjunctive ...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/dth.12259

    authors: Liu M,Li X,Chen XY,Xue F,Zheng J

    更新日期:2015-11-01 00:00:00

  • The impact of COVID-19 pandemic on the management of patients with chronic urticaria: An observational two-center study from Turkey.

    abstract::The Coronavirus Disease 2019 (COVID-19) outbreak significantly affected the clinical practice in hospitals and the management of many diseases. The aim of this study was to evaluate the effect of pandemic-related factors on the severity and course of chronic urticaria (CU). A total of 194 CU patients who were on regul...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.14652

    authors: Erdem Y,Polat Ekinci A,Altunay IK,Sivaz O,Inal S,Gokalp MO,Pehlivan G,Özkaya E

    更新日期:2020-12-10 00:00:00

  • Custom-made trays for targeted treatment of oral vesiculobullous diseases: A proposed protocol.

    abstract::Topical and intralesional corticosteroids (CS) are effective treatments for oral manifestations of autoimmune vesiculobullous diseases (VBD); however, may cause unnecessary absorption in the adjacent healthy mucosal surfaces, local infections, atrophy, and injection pain. To propose a protocol using a unique modality ...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.14446

    authors: Porat Ben Amy D,Kassem R

    更新日期:2020-11-01 00:00:00

  • Etiology of cicatricial alopecias: a basic science point of view.

    abstract::This article presents a short summary of our current knowledge of cicatricial alopecia disease pathogenesis and the hypothetical disease mechanisms that may be involved in scarring alopecia development. Several forms of scarring alopecia likely involve targeted cytotoxic action against hair follicle cells mediated by ...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1529-8019.2008.00202.x

    authors: McElwee KJ

    更新日期:2008-07-01 00:00:00

  • Safety and efficacy of single pass vs multipass emission with 755 alexandrite laser for all-skin-type hair removal: A pilot study.

    abstract::Lasers are considered the most efficient methods for hair reduction. The goal of these devices is to provide long-term effects without adverse reactions. This is a randomized split-body controlled study on body hair removal and pseudofolliculitis (PFC) treatment, comparing the standard single pass (SP) emission with t...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.14001

    authors: Bonan P,Troiano M,Verdelli A

    更新日期:2020-11-01 00:00:00

  • Oral propranolol administration is effective for infantile hemangioma in late infancy: A retrospective cohort study.

    abstract::The highest efficacy of oral propranolol is for infantile hemangioma (IH) in the proliferative phase. Evaluation of the effectiveness of oral propranolol is less established when it is administered in late infancy following the proliferative phase. We aimed to assess the clinical outcomes of pediatric patients managed...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.13331

    authors: Kridin K,Pam N,Bergman R,Khamaysi Z

    更新日期:2020-05-01 00:00:00

  • Long-term efficacy of biologics in the treatment of psoriasis: what do we really know?

    abstract::Psoriasis is a chronic inflammatory condition that often requires life-long treatment. Conventional therapies have not fully met the needs of psoriatic patients, because of limited efficacy, adverse effects with cumulative use, and patient inconvenience. In the past decade, biologic immunotherapies have become accepte...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1529-8019.2009.01259.x

    authors: Alwawi EA,Krulig E,Gordon KB

    更新日期:2009-09-01 00:00:00

  • Poly traditional Chinese medicine formulation prepared with skin moisturizing properties.

    abstract::Many traditional Chinese medicine compositions can moisturize the skin and utilize in cosmetics. Using a combination of Chinese Medicine Materials and guided by Traditional Chinese Medicine principles, this study selected Echinacea purpurea to protect the skin barrier, Dendrobium nobile to clear heat and promote fluid...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.14105

    authors: Meng H,Li J,Dong Y,He Y,Ren H,Liu Y,Qu Z,Zhang W,Zhang L,Bao T,Yi F

    更新日期:2020-11-01 00:00:00

  • Endogenous growth factors as cosmeceuticals.

    abstract::Growth factors play an important role in reversing the effects of skin aging mediated by chronological and environmental factors. Excessive oxidation of intra- and extracellular components result in breakdown of collagen and elastin network in the dermis and produce the effect of facial aging. Topical application of h...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1529-8019.2007.00149.x

    authors: Mehta RC,Fitzpatrick RE

    更新日期:2007-09-01 00:00:00

  • Effectiveness and safety of oral dutasteride for male androgenetic alopecia in real clinical practice: A descriptive monocentric study.

    abstract::The objective of our study was to describe the effectiveness and safety of oral dutasteride (OD) for male androgenetic alopecia in real clinical practice. A retrospective, monocentric, and descriptive study was designed. Male patients with androgenetic alopecia that had received OD for at least 12 months were included...

    journal_title:Dermatologic therapy

    pub_type: 信件

    doi:10.1111/dth.13182

    authors: Vañó-Galván S,Saceda-Corralo D,Moreno-Arrones OM,Rodrigues-Barata R,Morales C,Gil-Redondo R,Bernárdez-Guerra C,Hermosa-Gelbard Á,Jaén-Olasolo P

    更新日期:2020-01-01 00:00:00

  • Cutaneous malignant melanoma mortality in Andalusia from 1979 to 2018. Toward new perspectives?

    abstract::Malignant melanoma accounts for 80% of deaths due to skin cancer. Its incidence is globally increasing. However, melanoma mortality seems to be decreasing. The aim of this study was to analyze mortality rates due to melanoma in Andalusia between 1979 and 2018. Deaths due to melanoma and mid-year population in Andalusi...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.14715

    authors: Ortiz-Álvarez J,Durán-Romero AJ,Hernández-Rodríguez JC,Sendín-Martin M,Conejo-Mir J,Pereyra-Rodriguez JJ

    更新日期:2020-12-26 00:00:00

  • Efficacy and safety of Vismodegib treatment in patients with advanced basal cell carcinoma and multiple comorbidities.

    abstract::Basal cell carcinoma (BCC) is the most common malignancy in Caucasians, and its incidence is increasing. Most BCCs are treated surgically, nevertheless surgery is not an effective treatment for locally advanced or metastatic BCC. Alterations in hedgehog signaling pathway, a key regulator of cell growth and differentia...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.13108

    authors: Spallone G,Sollena P,Ventura A,Fargnoli MC,Gutierrez C,Piccerillo A,Tambone S,Bianchi L,Peris K

    更新日期:2019-11-01 00:00:00

  • Psoriasis in Tigray, Ethiopia: Focusing on available treatments.

    abstract::Psoriasis has been reported to be rare in people with skin of color. However, the actual prevalence is probably underestimated by the lack of wide epidemiological studies. The aim of the study is to present our experience in Tigray, Ethiopia, focusing on the issues related to diagnosis, clinical features and therapies...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.14718

    authors: Morrone A,Dell'Anna ML,Cristaudo A,Wubayehu T,Godefay H,Barnabas GA,Dassoni F,Padovese V,Latini O,Lotti T,Saraceni P,Di Domenico EG,Lora V

    更新日期:2020-12-27 00:00:00

  • Successful treatment of porocarcinoma with maxacalcitol and imiquimod.

    abstract::This is the first report of a case of porocarcinoma that was successfully treated with maxacalcitol and imiquimod. ...

    journal_title:Dermatologic therapy

    pub_type: 信件

    doi:10.1111/dth.12830

    authors: Nagasawa T,Hirata A,Niiyama S,Enomoto Y,Fukuda H

    更新日期:2019-03-01 00:00:00

  • Effectiveness of dermabrasion plus 5-fluorouracil vs suction blister in treating vitiligo: A comparative study.

    abstract::Vitiligo is a prevalent destructive melanocyte skin disease that negatively affects the patients' life in terms of self-esteem. Suction blister and dermabrasion plus 5-fluorouracil are effective treatments for vitiligo. The present study was conducted to compare the outcomes of these two techniques. The present clinic...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.14750

    authors: Asilian A,Kazemipour S,Mokhtari F,Iraji F,Shahmoradi Z,Mohaghegh F,Mozafarpoor S,Talakoub M

    更新日期:2021-01-05 00:00:00

  • Activation of Janus kinase signaling pathway in acne lesions.

    abstract::The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway has been linked to the pathogenesis of many inflammatory skin diseases; however, the role of JAKs in the pathogenesis of acne vulgaris has not been previously elucidated. We aimed to analyze the cutaneous expression of JAK1/...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.14563

    authors: Awad SM,Tawfik YM,El-Mokhtar MA,El-Gazzar AF,Abdel Motaleb AA

    更新日期:2020-11-19 00:00:00

  • Intravenous antibiotics used in dermatology.

    abstract::It is not common for dermatologists to use intravenous antibiotics in daily practice. However, there are several serious infections that may come to the attention of a dermatologist because of cutaneous signs and symptoms. It is important for dermatologists to be familiar with the presenting symptoms, various stages o...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1529-8019.2012.01533.x

    authors: Sambrano B,Gordon R,Mays R,Lapolla W,Scheinfeld N

    更新日期:2012-01-01 00:00:00

  • Update on retinoid therapy of psoriasis in: an update on the use of retinoids in dermatology.

    abstract::Both in the topical and systemic treatment of psoriasis, retinoids are mainstays. In this chapter the history and modes of actions of retinoids are presented. Tazarotene and acitretin are the only retinoids that are available in both topical and systemic formulations. A more extensive description of their pharmacology...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1529-8019.2006.00082.x

    authors: van de Kerkhof PC

    更新日期:2006-09-01 00:00:00

  • The efficacy of fractional ablative carbon dioxide laser combined with other therapies in acne scars.

    abstract::Fractional ablative carbon dioxide laser resurfacing is a frontline treatment for acne scars. It creates multiple microscopic treatment zones to accelerate the collagen formation and the healing process of reepithelialization, according the principle of fractional photothermolysis. At present, the fractional CO2 laser...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/dth.13084

    authors: Mu YZ,Jiang L,Yang H

    更新日期:2019-11-01 00:00:00

  • Successful treatment of angiolymphoid hyperplasia with eosinophilia and Kimura's disease in the same patient with surgery.

    abstract::Until now, there have only been two cases describing the coexistence of angiolymphoid hyperplasia with eosinophilia (ALHE) and Kimura's disease in one patient. Herein, we report the previous case of recurrent ALHE and Kimura's disease that was successfully treated with surgery. ...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.12040

    authors: Jun R,Liu XK,Zeng K

    更新日期:2014-01-01 00:00:00

  • TNF- alpha inhibitors.

    abstract::Tumor necrosis-alpha (TNF-alpha) has been implicated in many forms of inflammation and is an end-stage product of the inflammatory cytokine cascade. It is an inducer of inflammation and is involved in many cutaneous and systemic inflammatory diseases. The development of agents that block the effects of TNF-alpha has a...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1529-8019.2007.00138.x

    authors: Jackson JM

    更新日期:2007-07-01 00:00:00

  • Landscape of current and future therapies of Merkel cell carcinoma.

    abstract::Merkel cell carcinoma is rare and aggressive skin cancer, which occurrence is linked to exposure to ultraviolet light and the Merkel-cell polyomavirus. In recent years, significant progress in understanding the mechanism of Merkel cell carcinoma pathogenesis has been observed. This neoplasm often expresses PD-L1, and ...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/dth.13281

    authors: Kwiatkowska D,Reich A

    更新日期:2020-05-01 00:00:00

  • Acridone acetic acid, sodium salt, as an agent to stop vitiligo progression: a pilot study.

    abstract::Vitiligo progression is attributed to immune system malfunctioning, thus immunomodulating compounds might be beneficial in stopping vitiligo progression which is a prerequisite for successful repigmentation. The goal of this study was to assess efficacy of acridone acetic acid, sodium salt (Na-AAA), an immunomodulatin...

    journal_title:Dermatologic therapy

    pub_type: 临床试验,杂志文章

    doi:10.1111/dth.12121

    authors: Korobko IV,Lomonosov KM

    更新日期:2014-07-01 00:00:00

  • Infection and panniculitis.

    abstract::Infection-induced panniculitis may result from a number of microbes including bacteria, fungi, and parasites. Viruses have also been implicated as a cause. This type of panniculitis can occur as a primary infection by direct inoculation of infectious microorganisms into the subcutaneous tissue, or secondarily via micr...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1529-8019.2010.01333.x

    authors: Morrison LK,Rapini R,Willison CB,Tyring S

    更新日期:2010-07-01 00:00:00

  • Coronavirus disease (COVID-19): An updated review based on current knowledge and existing literature for dermatologists.

    abstract::The world entered the year 2020 with reports of the emergence of a new viral illness in Wuhan city, Hubei province, China. In January 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified to be the causative novel coronavirus for the cluster of patients suffering from pneumonia in China. Th...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/dth.13677

    authors: Kaur I,Sharma A,Jakhar D,Das A,Aradhya SS,Sharma R,Jindal V,Mhatre M

    更新日期:2020-07-01 00:00:00