Abstract:
:Vitiligo is a prevalent destructive melanocyte skin disease that negatively affects the patients' life in terms of self-esteem. Suction blister and dermabrasion plus 5-fluorouracil are effective treatments for vitiligo. The present study was conducted to compare the outcomes of these two techniques. The present clinical trial was conducted on 36 patients with persistent refractory vitiligo which defined as the lack of any new or progressed lesion during the previous year as well as no responding to conventional therapies of vitiligo including topical treatments and phototherapy. Individuals with two vitiligo patches, with similar baseline Vitiligo Area Severity Index (VASI) scores were randomly allocated to dermabrasion plus 5-fluorouracil or suction blister treatments. VASI and repigmentation scores were measured and compared at the baseline, four, and 12 weeks after performing the procedures. Both of the approaches accompanied with significant improvement in both entities of VASI and repigmentation scores (P value < .05) at the end of the study, besides the trend of VASI and repigmentation scores between the two groups revealed insignificant difference (P > .05). The short-term follow-up of the patients was the limitation of this study. The present findings suggested that both surgical techniques of dermabrasion plus 5-fluorouracil and suction blister posed acceptable outcomes within 12-week follow-up.
journal_name
Dermatol Therjournal_title
Dermatologic therapyauthors
Asilian A,Kazemipour S,Mokhtari F,Iraji F,Shahmoradi Z,Mohaghegh F,Mozafarpoor S,Talakoub Mdoi
10.1111/dth.14750subject
Has Abstractpub_date
2021-01-05 00:00:00pages
e14750eissn
1396-0296issn
1529-8019pub_type
杂志文章abstract::Verrucas are often recalcitrant to conventional cryotherapy. Since 1970, intralesional bleomycin has been used off-label by dermatologists. But in some cases, the results of intralesional bleomycin were disappointing. Vincristine is a well-known vinca alkaloid antiblastic drug that has been used for treating hematolog...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/j.1529-8019.2011.01425.x
更新日期:2011-05-01 00:00:00
abstract::Management of keloid is difficult, so there is always a need for adequate and effective therapy. In this study, we explored and compared the efficacy and synergistic effect of combined intralesional radiofrequency (RF) and intralesional triamcinolone acetonide (TAC) with intralesional triamcinolone acetonide alone in ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13919
更新日期:2020-11-01 00:00:00
abstract::A 57-year-old Caucasian female presented to our clinic with her 23-year-old son, who was profoundly autistic. Our patient was convinced that her son had an infestation with fibers and believed that he had developed the condition as a young child. She described the symptoms of the infestation in her son's skin on his b...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12724
更新日期:2018-11-01 00:00:00
abstract::Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, there has been an open debate on the impact of biological drugs used in the treatment of psoriasis. To define whether patients under treatment with biologics suffer from increased morbidity and mortality from COVID-19, compared to psoriatic patients ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14516
更新日期:2020-11-01 00:00:00
abstract::Psoriasis is a chronic inflammatory disease of the skin which can occur at any age-group. Psoriasis in childhood is not uncommon and has genetic susceptibility but usually, an environmental trigger such as infection is thought to initiate the disease process. Pediatric psoriasis has profound effects on both physical a...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.12571
更新日期:2018-01-01 00:00:00
abstract::It is not common for dermatologists to use intravenous antibiotics in daily practice. However, there are several serious infections that may come to the attention of a dermatologist because of cutaneous signs and symptoms. It is important for dermatologists to be familiar with the presenting symptoms, various stages o...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2012.01533.x
更新日期:2012-01-01 00:00:00
abstract::Duct tape occlusive therapy may represent a convenient alternative to the standard wart therapies. The objective of the current study is to assess the therapeutic effect of duct tape occlusion in comparison to cryotherapy in treatment of plantar warts in adults, in a prospective comparative randomized non-inferiority ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13342
更新日期:2020-05-01 00:00:00
abstract::Oral lichen planus (OLP) is a chronic inflammatory disease, has prolonged courses, repeated attacks and resistance to treatment. The traditional narrow spectrum UVB treatment has an established efficacy on skin lichen planus, and high safety. However, most of ultraviolet phototherapy devices have a huge volume, thereb...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12510
更新日期:2017-09-01 00:00:00
abstract::To evaluate the preventive practices in family members of melanoma patients regarding melanoma in Turkey and compare our results with similar studies by a literature review. A questionnaire-based, cross-sectional study was conducted in 52 participants over the age of 18 years. The questionnaire consisted of the items ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14268
更新日期:2020-11-01 00:00:00
abstract::Bexarotene is a retinoid that specifically binds retinoid X receptors and has numerous effects on cellular growth and differentiation. It is approved for the treatment of cutaneous T cell lymphoma both topically and systemically. Adverse effects include hyperlipidemia, central hypothyroidism, and neutropenia with bexa...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12087
更新日期:2013-09-01 00:00:00
abstract::Cumulative exposure to ultraviolet radiation (UVR) increases the risk of developing skin cancer, particularly squamous cell carcinoma and basal cell carcinoma. Thus, the need for protection from the sun is widely advocated, but consumers generally associate such protection with the occasional extreme exposure and tend...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1396-0296.2004.04s1007.x
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:There are conflicting results in the literature regarding the frequency of allergic diseases in COVID-19 patients. The effect of having an allergic disease on COVID-19 disease severity has been little studied. In this study, we tried to determine the frequency of allergic diseases in COVID-19 patients and th...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14581
更新日期:2020-11-25 00:00:00
abstract::Zoonoses are infectious diseases that can be transmitted from animals to humans. Transmission occurs directly or through vectors such as ticks, mosquitoes, or flies. The causative agents include bacteria, parasites, viruses, and fungi. Domestic pets and livestock, as well as wild animals, can be the source of disease....
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2009.01248.x
更新日期:2009-07-01 00:00:00
abstract::Covering wounds, acute and chronic, is one of the most fundamental activities of any medical practitioner. Although wound dressings primarily serve to contain the "good" and keep out the "bad," research has characterized more specifically the sophisticated interaction between the human wound bed and its dressing count...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.12055
更新日期:2013-05-01 00:00:00
abstract::Pemphigus encompasses a group of chronic autoimmune blistering diseases of the skin and/or mucosa. Rituximab (RTX) has shown promising efficacy for the treatment of pemphigus in the past decade. Considering potential cardiac side effects, this study was conducted to assess the effects of RTX on electrocardiogram (ECG)...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14299
更新日期:2020-11-01 00:00:00
abstract::Tattoos have long become a part of human civilization. However, as the number of people who get tattoos increases, so is the number of people who wish to have their tattoos removed. Compared to other methods, laser-based devices are associated with the best efficacy and least side effects in tattoo removal. Lack of un...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.14418
更新日期:2020-10-17 00:00:00
abstract::Scleredema is a deposition disorder which presents as diffuse, symmetric, non-pitting skin induration from dermal deposits of glycosaminoglycans ("mucins"). It classically affects the upper back and posterior neck, often causing skin tightness and decreased range of motion. In most patients the clinical course is chro...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.12504
更新日期:2017-07-01 00:00:00
abstract::The World Health Organization has recently defined the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections as a pandemic. The infection, which may cause a potentially very severe respiratory disease, now called coronavirus disease 2019 (COVID-19), has airborne transmission via droplets while less a...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13777
更新日期:2020-09-01 00:00:00
abstract::Tinea are superficial fungal infections caused by dermatophytes. Luliconazole exhibits highest antifungal activity against Trichophyton spp. which are major causative agents of dermatophytosis. However, luliconazole suffers from drawbacks such as less skin retention, low aqueous solubility and poor skin penetration. T...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13959
更新日期:2020-11-01 00:00:00
abstract::Skin cancers are the most common type of cancer. Nonmelanoma skin cancers (NMSCs) are more common than melanoma. Although the mortality rate is low, cancer word can be frightening for patients. Surgery is the main treatment. As skin cancers are most commonly located on the face, undesirable cosmetic results can occur ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14094
更新日期:2020-11-01 00:00:00
abstract::Acute urticaria is a self-limited cutaneous condition marked by transient, erythematous, and pruritic wheals. It is a hypersensitivity response that is often secondary to infection, medications, or food allergies in children. In contrast, the urticarial "mimickers" described in this review article are often seen in th...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.12103
更新日期:2013-11-01 00:00:00
abstract::The incidences of fungal infections have greatly increased over the past few years, particularly in humid and industrialized areas. The severity of such infections ranges from being asymptomatic-mild to potentially life-threatening systemic infections. There are limited classes of drugs that are approved for the treat...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.13905
更新日期:2020-11-01 00:00:00
abstract::Psoriasis is a chronic inflammatory condition that often requires life-long treatment. Conventional therapies have not fully met the needs of psoriatic patients, because of limited efficacy, adverse effects with cumulative use, and patient inconvenience. In the past decade, biologic immunotherapies have become accepte...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2009.01259.x
更新日期:2009-09-01 00:00:00
abstract::Treatment of severe psoriasis (PsO) in organ transplant (OT) patients is difficult. In fact, systemic drugs used for PsO therapy can be detrimental to transplanted organs and/or can increase the risk of serious infections in subjects already taking antireject medicines. Current guidelines fail to give indications on h...
journal_title:Dermatologic therapy
pub_type: 信件
doi:10.1111/dth.12909
更新日期:2019-05-01 00:00:00
abstract::Hair's importance in human communication means that abnormalities like excess hair in hirsutism or hair loss in alopecia cause psychological distress. Androgens are the main regulator of human hair follicles, changing small vellus follicles producing tiny, virtually invisible hairs into larger intermediate and termina...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2008.00214.x
更新日期:2008-09-01 00:00:00
abstract::The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway has been linked to the pathogenesis of many inflammatory skin diseases; however, the role of JAKs in the pathogenesis of acne vulgaris has not been previously elucidated. We aimed to analyze the cutaneous expression of JAK1/...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14563
更新日期:2020-11-19 00:00:00
abstract::Until now, there have only been two cases describing the coexistence of angiolymphoid hyperplasia with eosinophilia (ALHE) and Kimura's disease in one patient. Herein, we report the previous case of recurrent ALHE and Kimura's disease that was successfully treated with surgery. ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12040
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To explore the inhibition of the proliferation of vulvar squamous cell carcinoma (VSCC) by astragaloside IV. METHODS:MTT examined the cell proliferation of VSCC. Flow cytometry analyzed cell cycle and apoptosis. Western blot assay detected the expression of some relevant proteins. RESULTS:AS-IV reduced the ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12802
更新日期:2019-07-01 00:00:00
abstract::Behçet's disease (BD) is an autoimmune disease that affects many organs. We aimed to investigate the relationship between BD and these pregnancy-associated plasma protein A (PAPP-A), neopterin, and high sensitive C-reactive protein (hsCRP) parameters. The study included 57 BD patients and 54 healthy controls. After ev...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13443
更新日期:2020-07-01 00:00:00
abstract::Genital ulcer disease (GUD) constitutes a major public health problem. Most of them are the result of sexually transmitted diseases. Genital herpes, syphilis, lymphogranuloma venereum, granuloma venereum, or chancroid are the commonly encountered GUD. The treatment modalities for these disorders have changed with adve...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2008.00191.x
更新日期:2008-05-01 00:00:00