Abstract:
:Nucleosomes are typically located intracellularly, and extracellular levels of nucleosomes indicated the degree of cell death. We postulated aberrant nucleosomes expression in dermatomyositis (DM) and polymyositis (PM). To assess the aberrant expression of circulating nucleosomes in DM and polymyositis. 76 consecutive DM and PM patients from 1 September 2017 to 31 October 2018 were enrolled in this study, in addition to 20 healthy controls. The levels of circulating nucleosomes, with 16 kinds of detectable myositis-specific antibodies (MSAs) were detected in IIMs patients using enzyme-linked immunosorbent assay kit (ELISA). Receiver operating characteristic (ROC) curve analysis was performed for evaluating the ability of this candidate marker for detecting DM/PM. The results showed that the levels of circulating nucleosomes in DM/PM patients were significantly higher than that in normal individuals. Specifically, elevated levels of nucleosomes were associated with MDA5 Ab, ARS, and TIF1γAb. In addition, elevated levels of circulating nucleosomes correlated with skin eruption. This study has evidenced nucleosomes as a potential new biomarker of DM/PM. Aberrant nucleosomes expression occurs in myositis patients and the difference in nucleosomes expression between patients with and without skin eruption is statistically significant. A unique expression profile of elevated serum nucleosomes was detected in DM/PM-MDA5 Ab(+), ASS, and TIF1γAb(+).
journal_name
Dermatol Therjournal_title
Dermatologic therapyauthors
Zhong D,Wu C,Bai J,Zhao J,Xu D,Li M,Wang Q,Wang F,Zeng Xdoi
10.1111/dth.14460subject
Has Abstractpub_date
2020-11-01 00:00:00pages
e14460issue
6eissn
1396-0296issn
1529-8019journal_volume
33pub_type
杂志文章abstract::The world entered the year 2020 with reports of the emergence of a new viral illness in Wuhan city, Hubei province, China. In January 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified to be the causative novel coronavirus for the cluster of patients suffering from pneumonia in China. Th...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.13677
更新日期:2020-07-01 00:00:00
abstract::Various adverse events (AEs) have been reported to occur at a high rate in patients treated with dabrafenib plus trametinib (D + T) combination therapy. Among such AEs, the incidence of pyrexia was highest among the series of AEs in patients treated with D + T combination therapy. Although little is known about the me...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14544
更新日期:2020-11-14 00:00:00
abstract::Successful treatment of Hailey-Hailey disease with intradermal botulinum toxin injections has been previously reported. The main disadvantages of this treatment are the excruciating pain and the risk of infections due to the numerous injections. We sought to evaluate the clinical effectiveness and safety profile of a ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13184
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To explore the inhibition of the proliferation of vulvar squamous cell carcinoma (VSCC) by astragaloside IV. METHODS:MTT examined the cell proliferation of VSCC. Flow cytometry analyzed cell cycle and apoptosis. Western blot assay detected the expression of some relevant proteins. RESULTS:AS-IV reduced the ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12802
更新日期:2019-07-01 00:00:00
abstract::Some studies have demonstrated that neurotransmitters are involved in the pathogenesis of numerous skin conditions, including psoriasis, addressing the close correlation between the skin and the central nervous system. There are reports showing psoriasis improvement after peripheral nervous system injury. In addition,...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14319
更新日期:2020-11-01 00:00:00
abstract::Acne is known as a chronic inflammatory skin disease with sever adverse effects on quality of life in the patients. The increasing resistance to antibiotics has decreased their effectiveness in treating acne. As viable microbial dietary supplements, probiotics provide health benefits through fighting pathogens and mai...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.13279
更新日期:2020-05-01 00:00:00
abstract::Topical and intralesional corticosteroids (CS) are effective treatments for oral manifestations of autoimmune vesiculobullous diseases (VBD); however, may cause unnecessary absorption in the adjacent healthy mucosal surfaces, local infections, atrophy, and injection pain. To propose a protocol using a unique modality ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14446
更新日期:2020-11-01 00:00:00
abstract::It has been reported that dermatology practices may be a vector for SARS-CoV-2 transmission and elective cases should be postponed during the pandemic period. In this context, studies on the change of patient profile in Dermatology outpatient clinic have been conducted. However, there was no study in the literature ab...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13642
更新日期:2020-09-01 00:00:00
abstract::Melasma is a human melanogenesis dysfunction that results in localized, chronic acquired hyperpigmentation of the skin. It has a significant impact on appearance, causing psychosocial and emotional distress, and reducing the quality of life of the affected patients. Tranexamic acid (TA) is a plasmin inhibitor used to ...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.12465
更新日期:2017-05-01 00:00:00
abstract::Acute urticaria is a self-limited cutaneous condition marked by transient, erythematous, and pruritic wheals. It is a hypersensitivity response that is often secondary to infection, medications, or food allergies in children. In contrast, the urticarial "mimickers" described in this review article are often seen in th...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.12103
更新日期:2013-11-01 00:00:00
abstract::The World Health Organization has recently defined the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections as a pandemic. The infection, which may cause a potentially very severe respiratory disease, now called coronavirus disease 2019 (COVID-19), has airborne transmission via droplets while less a...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13777
更新日期:2020-09-01 00:00:00
abstract::Large difficult to heal ulcers of various etiologies carry a high morbidity and mortality rate. Becaplermin is a recombinant platelet-derived growth factor approved for treatment of diabetic ulcers. In this two-case series, we report the use of becaplermin in the treatment of ulcers due to (i) calciphylaxis, an often ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12318
更新日期:2016-03-01 00:00:00
abstract::Lasers are considered the most efficient methods for hair reduction. The goal of these devices is to provide long-term effects without adverse reactions. This is a randomized split-body controlled study on body hair removal and pseudofolliculitis (PFC) treatment, comparing the standard single pass (SP) emission with t...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14001
更新日期:2020-11-01 00:00:00
abstract::Moisturization is the pillar of daily skin care and has significant benefit in improving hydration, strengthening the skin barrier, and ameliorating inflammatory dermatoses. Bioactive ingredients such as endocannabinoids, bioactive lipids, growth factors, microbiome modulators, and antioxidant enzymes are increasingly...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13101
更新日期:2019-11-01 00:00:00
abstract::Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, there has been an open debate on the impact of biological drugs used in the treatment of psoriasis. To define whether patients under treatment with biologics suffer from increased morbidity and mortality from COVID-19, compared to psoriatic patients ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14516
更新日期:2020-11-01 00:00:00
abstract::Neutrophilic folliculitis is an often overlooked chronic condition characterized by a monomorphic eruption of "sterile" papulopustules. Neutrophilic folliculitis is often refractory to conventional treatment with topical and systemic antibiotics or isotretinoin. We report a case of severe pustular neutrophilic follicu...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12191
更新日期:2015-03-01 00:00:00
abstract::Health professions preventing and controlling Coronavirus Disease 2019 are prone to skin and mucous membrane injury, which may cause acute and chronic dermatitis, secondary infection and aggravation of underlying skin diseases. This is a consensus of Chinese experts on protective measures and advice on hand-cleaning- ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13310
更新日期:2020-07-01 00:00:00
abstract::The major therapeutic approaches (5-fluorouracil, imiquimod, vermilionectomy, and CO(2) Laser ablation) for actinic cheilitis are aimed at avoiding and preventing a malignant transformation into invasive squamous cell carcinoma via destruction/removal of the damaged epithelium. Recently, photodynamic therapy (PDT) has...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/j.1529-8019.2008.00224.x
更新日期:2008-09-01 00:00:00
abstract::Alternative methods are commonly used in patients with dermatologic diseases, with homeopathy being one of the most common. Homeopathy was developed by Samuel Hahnemann (1755-1843) and is based on the law of similars and the law of infinitesimals. It is a regulatory therapy where high dilutions of particular compounds...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1046/j.1529-8019.2003.01616.x
更新日期:2003-01-01 00:00:00
abstract::Leishmaniasis is a vector borne disease transmitted by phlebotomine sandflies. Cutaneous leishmaniasis (CL) predominantly causes skin ulcers but may disseminate. CL may present a therapeutic challenge. The present study reports the case of a 15-year old boy with CL consisting of a single, ulcer on the leg, resistant t...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13022
更新日期:2019-09-01 00:00:00
abstract::Pigmented lesions represent an enormous range of conditions, from benign to malignant tumors, and from infectious to post-inflammatory. Pigmented lesions are much less easily diagnosed on anogenital skin, and clinicians should have a low threshold for biopsy confirmation of diseases not classic in appearance. ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/j.1529-8019.2010.01349.x
更新日期:2010-09-01 00:00:00
abstract::Covering wounds, acute and chronic, is one of the most fundamental activities of any medical practitioner. Although wound dressings primarily serve to contain the "good" and keep out the "bad," research has characterized more specifically the sophisticated interaction between the human wound bed and its dressing count...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.12055
更新日期:2013-05-01 00:00:00
abstract::Leishmaniasis is an infectious disease caused by parasitic flagellates of the genus Leishmania. The authors present a case of 44-year-old man with Crohn's disease treated successfully with infliximab. This case report shows rare visceral leishmaniasis with cutaneous symptoms in an immunocompromised patient. Skin manif...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12083
更新日期:2014-05-01 00:00:00
abstract::Objective of this open, noninterventional, noncontrolled study was to investigate the tolerability and performance of a woad extract containing cream in subjects with dry, pruritic skin after twice daily application over 2 weeks. Assessments included sensorial characteristics, skin condition, pruritus (numeric rating ...
journal_title:Dermatologic therapy
pub_type: 杂志文章,多中心研究
doi:10.1111/dth.12939
更新日期:2019-07-01 00:00:00
abstract::Both in the topical and systemic treatment of psoriasis, retinoids are mainstays. In this chapter the history and modes of actions of retinoids are presented. Tazarotene and acitretin are the only retinoids that are available in both topical and systemic formulations. A more extensive description of their pharmacology...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2006.00082.x
更新日期:2006-09-01 00:00:00
abstract::Ischemic complications in cutaneous surgery can be devastating. Tissue ischemia can result from improper technique or closure design (i.e., increased tension), inadequate hemostasis, or infection, all of which result in decreased blood supply to the surgical site. Knowledge of patient characteristics that affect blood...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2012.01459.x
更新日期:2011-11-01 00:00:00
abstract::The recent EAACI/GA2 LEN/EDF/WAO guidelines recommend omalizumab (anti-IgE) for the management of patients aged ≥12 years with chronic urticaria unresponsive to high-doses second-generation H1 -antihistamines (antiH1 ). However, there is little published information on the success of omalizumab for such a treatment in...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13489
更新日期:2020-07-01 00:00:00
abstract::Until now, there have only been two cases describing the coexistence of angiolymphoid hyperplasia with eosinophilia (ALHE) and Kimura's disease in one patient. Herein, we report the previous case of recurrent ALHE and Kimura's disease that was successfully treated with surgery. ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12040
更新日期:2014-01-01 00:00:00
abstract::Tumor necrosis factor-alpha (TNF)-alpha inhibitors are licensed for patients with severe refractory psoriasis and psoriatic arthritis. However, TNF-alpha inhibitors have also been used off-label for various recalcitrant mucocutaneous diseases. This study aimed to evaluate the efficacy and safety of TNF-alpha inhibitor...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12222
更新日期:2015-05-01 00:00:00
abstract::Diphenylcyclopropenone (DPCP) immunotherapy has been shown to be efficacious for the treatment of warts, especially periungual warts for which destructive techniques are limited. However, factors affecting the duration of treatment of periungual warts have not been studied. A total of 61 patients with periungual warts...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12312
更新日期:2016-03-01 00:00:00