Abstract:
:Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe adverse cutaneous drug reaction with mortality up to 10%. It is a rare condition with risk varying between 1 in 1000 and 1 in 10 000 drug exposures. The aim of the study was to describe clinical features, management and drugs responsible for causing DRESS. The study was retrospective, observational study. The data of patients admitted to hospital with diagnosis of DRESS during study period (March 2018 to February 2020), were retrieved and analyzed. The descriptive data of patients were summarized. The continuous variables were summarized as mean ± SD and/or median, depending on the skewness of the data. The categorical variables were expressed as absolute numbers, frequency, and proportions (%). The data was tabulated and analyzed in Microsoft Excel 2019 version. A total of 20 patients who met inclusion criteria (probable or definite DRESS as per RegiSCAR criteria) were included in the study. The mean age of the patients was 41.2 ± 15.7 years. The average latency period was 26.45 ± 5.65 days (range: 7-60). The commonest culprit drugs were dapsone and phenytoin, each in five (25%) patients. Commonest morphology of rash was morbilliform in 13 (65%) patients. One patient with targetoid rash had multi-organ involvement. Facial edema, periorbital edema, and conjunctival injection were seen in 17 (85%), seven (35%), and six (30%) cases, respectively. Eosinophilia was present in 18 (90%) patients with mean (±SD) value of 1976 ± 840 cells/μl. Liver was the commonest internal organ involved in 14 (70%) patients and kidney in three (15%) patients. The initial dose of prednisolone for treatment varied from 0.75 to 2 mg/kg/day. The mean duration of steroid treatment was 64 ± 21 days. Two patients were treated with intravenous methylprednisolone and one with intravenous immunoglobulin. Two patients (10%) had recurrence of adverse drug reaction >6 months after completion of initial treatment and two (10%) developed autoimmune thyroiditis during follow-up. Small sample size and retrospective nature of the study were main limitations. Selection bias is a possibility as study was carried out in tertiary care center. Tests for incriminating culprit drugs such as patch test, intradermal test, and lymphocyte transformation test were not performed. DRESS is a rare disease that can be diagnosed early with high index of suspicion and treated successfully with steroids. The internal organ involvement is common in DRESS and requires a thorough evaluation.
journal_name
Dermatol Therjournal_title
Dermatologic therapyauthors
Sandhu S,Neema S,Vashisht D,Venugopal R,Sengupta P,Radhakrishnan Sdoi
10.1111/dth.14670subject
Has Abstractpub_date
2020-12-14 00:00:00pages
e14670eissn
1396-0296issn
1529-8019pub_type
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
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doi:10.1111/dth.13438
更新日期:2020-07-01 00:00:00
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journal_title:Dermatologic therapy
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doi:10.1111/dth.12096
更新日期:2014-05-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
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journal_title:Dermatologic therapy
pub_type: 杂志文章
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journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14750
更新日期:2021-01-05 00:00:00
abstract::Hand-foot syndrome (HFS) is a specific cutaneous toxicity caused by a variety of antitumor drugs. The most common drugs include capecitabine, pegylated liposomal doxorubicin and fluorouracil (PLD), tyrosine kinase inhibitor. It is a dose-limiting cutaneous toxicity of these drugs. We reported an advanced lung adenocar...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13241
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journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.12276
更新日期:2016-01-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12215
更新日期:2015-07-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/j.1529-8019.2008.00224.x
更新日期:2008-09-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14105
更新日期:2020-11-01 00:00:00
abstract::Smooth, lustrous nails are a sign of health and beauty in our society and fuel the US$6-billion nail salon industry in the United States. Although many women can use nail cosmetics without adverse consequences, when problems occur it is important to recognize the causes and treat the problem condition. The cornerstone...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2007.00111.x
更新日期:2007-01-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12061
更新日期:2014-03-01 00:00:00
abstract::Psoriatic patients with latent tuberculosis infection (LTBI) need a prophylaxis before starting a treatment with biological drugs. The aim of this study is to investigate the safety and efficacy of prophylaxis of LTBI in psoriatic patients receiving long-term biological drugs. The study included 56 patients (42 male a...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12503
更新日期:2017-09-01 00:00:00
abstract::Filiform warts are commonly treated with surgical removal or cryotherapy, yet such treatment modalities may result in complications for darker skin types. We report a man successfully treated for more than 50 filiform facial warts using a combination of 5-fluorouracil 5% and salicylic acid 20%. ...
journal_title:Dermatologic therapy
pub_type: 信件
doi:10.1111/dth.13235
更新日期:2020-03-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14359
更新日期:2020-11-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 信件
doi:10.1111/dth.12845
更新日期:2019-05-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 临床试验,杂志文章
doi:10.1111/j.1529-8019.2009.01265.x
更新日期:2009-11-01 00:00:00
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journal_title:Dermatologic therapy
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更新日期:2020-05-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
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journal_title:Dermatologic therapy
pub_type: 杂志文章
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更新日期:2019-07-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
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更新日期:2020-07-01 00:00:00
abstract::Lasers and other light sources are popular treatment options for facial rejuvenation in recent years. In this study, we aimed to compare the efficacy and safety of fractional radiofrequency (RF) and fractional Erbium: YAG (Er:YAG) laser for facial and neck skin wrinkles, objectively. Three hundred and thirty-three pat...
journal_title:Dermatologic therapy
pub_type: 杂志文章
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更新日期:2019-09-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章,随机对照试验
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更新日期:2015-11-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Dermatologic therapy
pub_type: 杂志文章
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更新日期:2020-12-27 00:00:00
abstract::Vitiligo is a systemic disease that affects not only the skin but also other areas that contain melanocytes, such as the inner ear. Studies of the effect of vitiligo on hearing loss have shown inconsistent results, and it is not clear which parameters related to the disease affect hearing. The aim of this study was to...
journal_title:Dermatologic therapy
pub_type: 杂志文章
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更新日期:2020-07-01 00:00:00