Etiology of cicatricial alopecias: a basic science point of view.

Abstract:

:This article presents a short summary of our current knowledge of cicatricial alopecia disease pathogenesis and the hypothetical disease mechanisms that may be involved in scarring alopecia development. Several forms of scarring alopecia likely involve targeted cytotoxic action against hair follicle cells mediated by a folliculocentric inflammation. However, the specific nature of the inflammatory interference in hair follicle growth is open to question. A popular hypothesis of lymphocyte-mediated scarring alopecia development involves autoimmune targeting of hair follicle-specific self-antigens, although there is no direct evidence in support of such a view. Alternative hypotheses focus on defects in sebaceous gland function, destruction of hair follicle stem cells, and interference in the communication between hair follicle mesenchyme and epithelium. Many questions arise from these hypotheses, and addressing them with a systematic research approach may enable significant advances in understanding cicatricial alopecia etiology.

journal_name

Dermatol Ther

journal_title

Dermatologic therapy

authors

McElwee KJ

doi

10.1111/j.1529-8019.2008.00202.x

subject

Has Abstract

pub_date

2008-07-01 00:00:00

pages

212-20

issue

4

eissn

1396-0296

issn

1529-8019

pii

DTH202

journal_volume

21

pub_type

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