Abstract:
:This article presents a short summary of our current knowledge of cicatricial alopecia disease pathogenesis and the hypothetical disease mechanisms that may be involved in scarring alopecia development. Several forms of scarring alopecia likely involve targeted cytotoxic action against hair follicle cells mediated by a folliculocentric inflammation. However, the specific nature of the inflammatory interference in hair follicle growth is open to question. A popular hypothesis of lymphocyte-mediated scarring alopecia development involves autoimmune targeting of hair follicle-specific self-antigens, although there is no direct evidence in support of such a view. Alternative hypotheses focus on defects in sebaceous gland function, destruction of hair follicle stem cells, and interference in the communication between hair follicle mesenchyme and epithelium. Many questions arise from these hypotheses, and addressing them with a systematic research approach may enable significant advances in understanding cicatricial alopecia etiology.
journal_name
Dermatol Therjournal_title
Dermatologic therapyauthors
McElwee KJdoi
10.1111/j.1529-8019.2008.00202.xsubject
Has Abstractpub_date
2008-07-01 00:00:00pages
212-20issue
4eissn
1396-0296issn
1529-8019pii
DTH202journal_volume
21pub_type
杂志文章,评审abstract::For many years, drug therapies were not explicitly studied in the pediatric population. The lack of data forced clinicians to treat children using empiric therapy, often guessing at the treatment dose. In addition to the lack of dosing information, there was no evidence that a product would be safe and efficacious in ...
journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
pub_type: 信件
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pub_type: 临床试验,杂志文章
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
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pub_type: 杂志文章,多中心研究
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