Abstract:
:Febrile ulcero-necrotic Mucha-Habermann disease (FUMHD) is a rare subtype of pityriasis lichenoides et varioliformis acuta (only 41 cases described to date), characterized by an acute onset of ulcero-necrotic papules accompanied by high fever and severe constitutional symptoms. We report a case of a 23-year-old man with a steroid-resistant FUMHD treated by intravenous immunoglobulins (IVIG) combined with methotrexate. Only one case of FUMHD treated by IVIG has been reported to date in literature. Also in our case, IVIG proved to be effective in inducing a dramatic improvement of ulceration and in arresting the appearance of new lesions. Moreover, in our experience we decided to perform a maintenance treatment with extracorporeal photochemotherapy (ECP), to the best of our knowledge not previously used in the treatment of pityriasis lichenoides et varioliformis acuta. ECP, which involves extracorporeal exposure of peripheral blood mononuclear cells to photo-activated 8-methoxypsoralen, induces an immunological reaction against auto-reactive T cell clones, without immune-depression and thus could potentially be useful particularly in FUMHD avoiding the risk of an infective reactivation.
journal_name
Dermatol Therjournal_title
Dermatologic therapyauthors
Marenco F,Fava P,Fierro MT,Quaglino P,Bernengo MGdoi
10.1111/j.1529-8019.2010.01343.xsubject
Has Abstractpub_date
2010-07-01 00:00:00pages
419-22issue
4eissn
1396-0296issn
1529-8019pii
DTH1343journal_volume
23pub_type
杂志文章abstract::This study evaluated the efficacy and tolerability of topical aluminum sesquichlorohydrate (AS) when compared to aluminum chloride (AC) as a treatment for primary axillary hyperhidrosis (PAH). Twenty subjects were included in this randomized, controlled, split-side 8-week study. All participants applied 20% AS and 20%...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14354
更新日期:2020-11-01 00:00:00
abstract::Tinea pedis affects the life quality distinctly and patients those with a prolonged disease often resort to non-medical methods. We sought to evaluate patients' knowledge about tinea pedis and approaches to the non-pharmacological agents. A cross-sectional study was conducted on 152 patients with tinea pedis who answe...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14041
更新日期:2020-11-01 00:00:00
abstract::Desquamative inflammatory vaginitis (DIV) is not a diagnosis in itself, and may be the presentation of a range of blistering disorders including pemphigus vulgaris, lichen planus and mucous membrane pemphigoid. The existence of an idiopathic subset of DIV remains controversial and is discussed in the present article. ...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1396-0296.2004.04006.x
更新日期:2004-01-01 00:00:00
abstract::Management of keloid is difficult, so there is always a need for adequate and effective therapy. In this study, we explored and compared the efficacy and synergistic effect of combined intralesional radiofrequency (RF) and intralesional triamcinolone acetonide (TAC) with intralesional triamcinolone acetonide alone in ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13919
更新日期:2020-11-01 00:00:00
abstract::The skin plays a critical role in the detection of internal malignances. Cutaneous signs of these disorders afford clinicians opportunities for early diagnosis and treatment. We aim to succinctly review the recognition, diagnosis, and treatment of selected cutaneous paraneoplastic diseases. Skin disorders that may be ...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2010.01371.x
更新日期:2010-11-01 00:00:00
abstract::The development of effective and well-tolerated biologic therapies has advanced the management of psoriasis by enabling clinicians to treat underlying disease mechanisms. Biologics approved for the treatment of moderate-to-severe psoriasis include three tumor necrosis factor alpha inhibitors and an interleukin-12/inte...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.12251
更新日期:2015-07-01 00:00:00
abstract::Epidermolytic acanthoma is an uncommon benign tumor with a predilection for the anogenital region, that is characterized histologically by epidermolytic hyperkeratosis. Most reported cases are asymptomatic while some are pruritic. Treatment of this condition is challenging and not well studied. We report a 55-year-old...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12068
更新日期:2014-03-01 00:00:00
abstract::Maffucci syndrome is characterized by multiple benign vascular anomalies and enchondromas present on the distal extremities. Effective treatment options are currently not available for Maffucci syndrome-associated vascular lesions. Sirolimus is a mTOR pathway inhibitor, and has been tried successfully in the treatment...
journal_title:Dermatologic therapy
pub_type: 信件
doi:10.1111/dth.12851
更新日期:2019-05-01 00:00:00
abstract::The objective of our study was to describe the effectiveness and safety of oral dutasteride (OD) for male androgenetic alopecia in real clinical practice. A retrospective, monocentric, and descriptive study was designed. Male patients with androgenetic alopecia that had received OD for at least 12 months were included...
journal_title:Dermatologic therapy
pub_type: 信件
doi:10.1111/dth.13182
更新日期:2020-01-01 00:00:00
abstract::Intralesional methotrexate (il-MTX) has been reported as a useful therapy in keratoacanthoma (KA) and cutaneous squamous cell carcinoma (cSCC). However, the data available on the histological changes induced by this therapy are very scarce. We conducted a single center, prospective study that included 65 cases of cSCC...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14377
更新日期:2020-11-01 00:00:00
abstract::Cumulative exposure to ultraviolet radiation (UVR) increases the risk of developing skin cancer, particularly squamous cell carcinoma and basal cell carcinoma. Thus, the need for protection from the sun is widely advocated, but consumers generally associate such protection with the occasional extreme exposure and tend...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1396-0296.2004.04s1007.x
更新日期:2004-01-01 00:00:00
abstract::It is not common for dermatologists to use intravenous antibiotics in daily practice. However, there are several serious infections that may come to the attention of a dermatologist because of cutaneous signs and symptoms. It is important for dermatologists to be familiar with the presenting symptoms, various stages o...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2012.01533.x
更新日期:2012-01-01 00:00:00
abstract::Leishmaniasis is a vector borne disease transmitted by phlebotomine sandflies. Cutaneous leishmaniasis (CL) predominantly causes skin ulcers but may disseminate. CL may present a therapeutic challenge. The present study reports the case of a 15-year old boy with CL consisting of a single, ulcer on the leg, resistant t...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13022
更新日期:2019-09-01 00:00:00
abstract::The recent EAACI/GA2 LEN/EDF/WAO guidelines recommend omalizumab (anti-IgE) for the management of patients aged ≥12 years with chronic urticaria unresponsive to high-doses second-generation H1 -antihistamines (antiH1 ). However, there is little published information on the success of omalizumab for such a treatment in...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13489
更新日期:2020-07-01 00:00:00
abstract::Acne is known as a chronic inflammatory skin disease with sever adverse effects on quality of life in the patients. The increasing resistance to antibiotics has decreased their effectiveness in treating acne. As viable microbial dietary supplements, probiotics provide health benefits through fighting pathogens and mai...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.13279
更新日期:2020-05-01 00:00:00
abstract::Neutrophilic folliculitis is an often overlooked chronic condition characterized by a monomorphic eruption of "sterile" papulopustules. Neutrophilic folliculitis is often refractory to conventional treatment with topical and systemic antibiotics or isotretinoin. We report a case of severe pustular neutrophilic follicu...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12191
更新日期:2015-03-01 00:00:00
abstract::Psoriasis is a chronic inflammatory condition that often requires life-long treatment. Conventional therapies have not fully met the needs of psoriatic patients, because of limited efficacy, adverse effects with cumulative use, and patient inconvenience. In the past decade, biologic immunotherapies have become accepte...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2009.01259.x
更新日期:2009-09-01 00:00:00
abstract::Health professions preventing and controlling Coronavirus Disease 2019 are prone to skin and mucous membrane injury, which may cause acute and chronic dermatitis, secondary infection and aggravation of underlying skin diseases. This is a consensus of Chinese experts on protective measures and advice on hand-cleaning- ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13310
更新日期:2020-07-01 00:00:00
abstract::Onychomycosis is an important medical disorder affecting both health and quality of life of patients. This study was done to compare the efficacy of CO2 laser in combination with topical tioconazole versus CO2 laser only versus topical tioconazole alone in onychomycosis. A total of 120 patients with onychomycosis were...
journal_title:Dermatologic therapy
pub_type: 杂志文章,随机对照试验
doi:10.1111/dth.13155
更新日期:2020-01-01 00:00:00
abstract::Photodynamic therapy (PDT) is an established nonsurgical treatment for nodular basal cell carcinoma (nBCC). This study compares the clinical, histopathological, and immunohistochemical findings in recurrent nBCC after PDT versus pre-treatment (primary) nBCC. This retrospective study analyzed nodular BCCs treated with ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14779
更新日期:2021-01-13 00:00:00
abstract::Pemphigus is a group of autoimmune diseases characterized by the formation of erosions and/or flaccid bullae of the skin and/or mucosae. The definition "drug-induced pemphigus" has been coined to indicate cases of pemphigus with clinical, histological and immunopathologic features similar to those of the idiopathic di...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.12748
更新日期:2019-01-01 00:00:00
abstract::Daylight-photodynamic therapy (D-PDT) and ingenol mebutate (IM) are novel therapies directed to actinic keratoses (AK). The purpose of our study was to compare effectiveness, tolerability, cosmetic outcome and patient preference of D-PDT versus IM in the treatment of grade I and II AK. Twenty-seven patients with AK on...
journal_title:Dermatologic therapy
pub_type: 临床试验,杂志文章
doi:10.1111/dth.12334
更新日期:2016-05-01 00:00:00
abstract::Prostaglandins and their analogues are beneficial as topical agents in vitiligo treatment, yet neither of the previous study addressed their comparative efficiency with conventional topical agents used in vitiligo treatment. In this pilot (24 patients) left-right comparative study we addressed efficiency of prostaglan...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12383
更新日期:2016-11-01 00:00:00
abstract::Prayer marks are asymptomatic callosities resulting from repeated, extended pressure, and friction exerted on bony prominences when praying on hard ground. A 41-year-old woman with ulcerative colitis treated with infliximab was referred to our clinic due to skin changes on her feet that were suspected to be drug erupt...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.13176
更新日期:2020-01-01 00:00:00
abstract::Both in the topical and systemic treatment of psoriasis, retinoids are mainstays. In this chapter the history and modes of actions of retinoids are presented. Tazarotene and acitretin are the only retinoids that are available in both topical and systemic formulations. A more extensive description of their pharmacology...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2006.00082.x
更新日期:2006-09-01 00:00:00
abstract::Epidermolysis bullosa (EB) is a group of rare heterogeneous, genetic disorders. Currently, there is no effective pharmacological or genetic therapy for all EB subtypes. Dry extract from birch bark and betulin upregulate some pro-inflammatory mediators and downregulate others. The increase in pro-inflammatory cytokines...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.12983
更新日期:2019-07-01 00:00:00
abstract::Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, there has been an open debate on the impact of biological drugs used in the treatment of psoriasis. To define whether patients under treatment with biologics suffer from increased morbidity and mortality from COVID-19, compared to psoriatic patients ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14516
更新日期:2020-11-01 00:00:00
abstract::Mycobacterium W (Mw) vaccine has been found to be effective in the treatment of leprosy and warts. Despite increasing use of Mw immunotherapy, data on its safety is limited. We report a series of eight patients who developed persisting injection site granulomatous reaction following Mw immunotherapy and were successfu...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12452
更新日期:2017-03-01 00:00:00
abstract::To date, the geographical distribution and global trends of search activities on psoriasis and atopic eczema on Google and YouTube are widely unknown. The aim of this study was to identify geographic and temporal trends in YouTube and Google search activities for psoriasis and atopic eczema. We used specific filter se...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13510
更新日期:2020-07-01 00:00:00
abstract::Photodermatoses can be classified into five general categories: 1) idiopathic photodermatoses, including polymorphic light eruption (PMLE), actinic prurigo, hyroa vacciniforme, chronic actinic dermatitis, and solar urticaria; 2) photodermatoses which are secondary to exogenous agents, including phototoxic and photoall...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1046/j.1529-8019.2003.01601.x
更新日期:2003-01-01 00:00:00