Alitretinoin and acitretin in severe chronic hand eczema; results from a retrospective daily practice study.

Abstract:

:Acitretin has been used off-label for years to treat chronic hand eczema, but acitretin is less often prescribed as alitretinoïne was approved. This study evaluates both retinoids in a daily practice cohort of patients with severe chronic hand eczema in terms of drug survival and reasons for discontinuation. Patients using alitretinoin or acitretin between 01-01-1994 and 01-08-2015 were included in this retrospective daily practice study and analyzed by Kaplan-Meier drug survival curves. Potential determinants were analyzed by Cox regression analyses. Ninety-five patients were treated with alitretinoin and 109 patients with acitretin. The main reasons for discontinuation were adverse events and cleared hand eczema, 29.5 and 27.4% in alitretinoin versus 43.1 and 23.9% in acitretin. Patients with hyperkeratotic hand eczema had most often a good effect of treatment: 68.3% in alitretinoin and 50.7% in acitretin treatment. The drug survival rates of alitretinoin and acitretin after 12, 24, 36, and 52 weeks were 69.3, 45.1, 19.6, 7.0% and 74.3, 45.5, 33.8, 23.2%, respectively. Alitretinoin and acitretin are effective treatment options for patients with hand eczema. However, both treatments were more effective in patients with hyperkeratotic hand eczema. Fewer patients discontinued alitretinoin compared with acitretin due to adverse events.

journal_name

Dermatol Ther

journal_title

Dermatologic therapy

authors

Politiek K,Christoffers WA,Coenraads PJ,Schuttelaar MA

doi

10.1111/dth.12362

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

364-371

issue

5

eissn

1396-0296

issn

1529-8019

journal_volume

29

pub_type

杂志文章
  • A pilot comparative study of topical latanoprost and tacrolimus in combination with narrow-band ultraviolet B phototherapy and microneedling for the treatment of nonsegmental vitiligo.

    abstract::Prostaglandins and their analogues are beneficial as topical agents in vitiligo treatment, yet neither of the previous study addressed their comparative efficiency with conventional topical agents used in vitiligo treatment. In this pilot (24 patients) left-right comparative study we addressed efficiency of prostaglan...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.12383

    authors: Korobko IV,Lomonosov KM

    更新日期:2016-11-01 00:00:00

  • Combination therapy with zinc gluconate and PUVA for alopecia areata totalis: an adjunctive but crucial role of zinc supplementation.

    abstract::Spontaneous remission occurs in less than 10% of patients suffering from alopecia areata (AA) totalis for more than 2 years. The efficacy of PUVA therapy is controversial due to recurrence of hair loss after cessation. We report two cases presenting with AA totalis and AA universalis. After hair regrowth, relapse of h...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.12215

    authors: Lux-Battistelli C

    更新日期:2015-07-01 00:00:00

  • Coronavirus disease (COVID-19): An updated review based on current knowledge and existing literature for dermatologists.

    abstract::The world entered the year 2020 with reports of the emergence of a new viral illness in Wuhan city, Hubei province, China. In January 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified to be the causative novel coronavirus for the cluster of patients suffering from pneumonia in China. Th...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/dth.13677

    authors: Kaur I,Sharma A,Jakhar D,Das A,Aradhya SS,Sharma R,Jindal V,Mhatre M

    更新日期:2020-07-01 00:00:00

  • In vivo confocal reflectance microscopy in melanoma.

    abstract::Reflectance confocal microscopy (RCM) enables the noninvasive in vivo imaging of the skin with a horizontal axis and a cellular-level resolution allowing the study of the skin from superficial layers to papillary dermis. It has arisen an important tool in the study of tumors and specially an important role in the char...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/j.1529-8019.2012.01495.x

    authors: Carrera C,Puig S,Malvehy J

    更新日期:2012-09-01 00:00:00

  • Comparative evaluation of therapeutic efficacy and safety of intralesional triamcinolone acetonide injection vs intralesional radiofrequency with intralesional triamcinolone acetonide in treatment of keloids.

    abstract::Management of keloid is difficult, so there is always a need for adequate and effective therapy. In this study, we explored and compared the efficacy and synergistic effect of combined intralesional radiofrequency (RF) and intralesional triamcinolone acetonide (TAC) with intralesional triamcinolone acetonide alone in ...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.13919

    authors: Kaushal V,Kumar S,Brar BK,Singh A

    更新日期:2020-11-01 00:00:00

  • Effective treatment with photodynamic therapy of cutaneous leishmaniasis: A case report.

    abstract::Leishmaniasis is a vector borne disease transmitted by phlebotomine sandflies. Cutaneous leishmaniasis (CL) predominantly causes skin ulcers but may disseminate. CL may present a therapeutic challenge. The present study reports the case of a 15-year old boy with CL consisting of a single, ulcer on the leg, resistant t...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.13022

    authors: Johansen MB,Jemec GBE,Fabricius S

    更新日期:2019-09-01 00:00:00

  • Experience with oral tofacitinib in two adolescents and seven adults with alopecia areata.

    abstract::Alopecia areata (AA) is a common disease that results in nonscarring hair loss. Recently, tofacitinib (TOFA) has been a novel promising therapy for AA. The aim of this study is to determine the efficacy of oral TOFA treatment for alopecia areata (AA), and alopecia universalis (AU). Data of nine patients treated with o...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.13118

    authors: Akdogan N,Ersoy-Evans S,Doğan S,Atakan N

    更新日期:2019-11-01 00:00:00

  • Landscape of current and future therapies of Merkel cell carcinoma.

    abstract::Merkel cell carcinoma is rare and aggressive skin cancer, which occurrence is linked to exposure to ultraviolet light and the Merkel-cell polyomavirus. In recent years, significant progress in understanding the mechanism of Merkel cell carcinoma pathogenesis has been observed. This neoplasm often expresses PD-L1, and ...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/dth.13281

    authors: Kwiatkowska D,Reich A

    更新日期:2020-05-01 00:00:00

  • Malignant melanoma in organ transplant recipients: incidence, outcomes, and management strategies: a review of literature.

    abstract::Malignant melanoma is considered to be an immunogenic tumor, which is expected to change its behaviour in the field of immunosuppression. Although the incidence of melanoma in organ transplant recipients is increased to a smaller degree than in non-melanoma skin cancer, its potential morbidity and mortality has to be ...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/dth.12276

    authors: Džambová M,Sečníková Z,Jiráková A,Jůzlová K,Viklický O,Hošková L,Göpfertovà D,Hercogová J

    更新日期:2016-01-01 00:00:00

  • Chemical and mechanical characterization of hyaluronic acid hydrogel cross-linked with polyethylen glycol and its use in dermatology.

    abstract::Hydrogels based on hyaluronic acid are used to restore volume, hydration, and skin tone, as well as to correct scars, asymmetries or defects of the soft tissue. Hyaluronic acid is often chemically crosslinked with different crosslinking agents in order to improve its mechanical and biological properties. Here we focus...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.13747

    authors: Zerbinati N,Esposito C,Cipolla G,Calligaro A,Monticelli D,Martina V,Golubovic M,Binic I,Sigova J,Gallo AL,D'Este E,Jafferany M,Pratosoni M,Tirant M,Van Thuong N,Sangalli F,Rauso R,Lotti T

    更新日期:2020-07-01 00:00:00

  • The art and science of oral examination.

    abstract::Performing an accurate oral examination is an integral part of a complete dermatological evaluation. As dermatologists, we are frequently asked to assess and treat numerous oral pathologies, which include, but are not limited to, normal variants, infections, ulcers, granulomas, lymphomas, as well as primary and metast...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/j.1529-8019.2010.01318.x

    authors: Agha R,Mirowski GW

    更新日期:2010-05-01 00:00:00

  • Intralesional vincristine combined with cryotherapy for recalcitrant verrucas.

    abstract::Verrucas are often recalcitrant to conventional cryotherapy. Since 1970, intralesional bleomycin has been used off-label by dermatologists. But in some cases, the results of intralesional bleomycin were disappointing. Vincristine is a well-known vinca alkaloid antiblastic drug that has been used for treating hematolog...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/j.1529-8019.2011.01425.x

    authors: Lee JR,Youn JH,Roh JY

    更新日期:2011-05-01 00:00:00

  • Cutaneous sıde-effects of the potential COVID-19 drugs.

    abstract::COVID-19 disease is a highly contagious and particularly popular problem in all countries. A variety of repurposed drugs and investigational drugs such as remdesivir, chloroquine, hydroxychloroquine, ritonavir, lopinavir, interferon-beta, and other potential drugs have been studied for COVID19 treatment. We reviewed t...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/dth.13476

    authors: Türsen Ü,Türsen B,Lotti T

    更新日期:2020-07-01 00:00:00

  • Investigation of pregnancy associated plasma protein-A and neopterin levels in Behçet's patients.

    abstract::Behçet's disease (BD) is an autoimmune disease that affects many organs. We aimed to investigate the relationship between BD and these pregnancy-associated plasma protein A (PAPP-A), neopterin, and high sensitive C-reactive protein (hsCRP) parameters. The study included 57 BD patients and 54 healthy controls. After ev...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.13443

    authors: Akyurek F,Tuncez Akyurek F

    更新日期:2020-07-01 00:00:00

  • Treatment of COVID-19 with pentoxifylline: Could it be a potential adjuvant therapy?

    abstract::The world is facing a viral pandemic of a new coronavirus called COVID-19. Pentoxifylline is a methyl-xanthine derivative and it inhibits the phosphodiesterase IV (PDE IV). This drug is known for its unique features as an immunomodulatory and anti-inflammatory agent, also it could have antiviral affects. This is a sco...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/dth.13733

    authors: Seirafianpour F,Mozafarpoor S,Fattahi N,Sadeghzadeh-Bazargan A,Hanifiha M,Goodarzi A

    更新日期:2020-07-01 00:00:00

  • The potential of probiotics for treating acne vulgaris: A review of literature on acne and microbiota.

    abstract::Acne is known as a chronic inflammatory skin disease with sever adverse effects on quality of life in the patients. The increasing resistance to antibiotics has decreased their effectiveness in treating acne. As viable microbial dietary supplements, probiotics provide health benefits through fighting pathogens and mai...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/dth.13279

    authors: Goodarzi A,Mozafarpoor S,Bodaghabadi M,Mohamadi M

    更新日期:2020-05-01 00:00:00

  • Angiotensin-converting-enzyme inhibitors and angiotensin II receptor blockers induced pemphigus: A case series and literature review.

    abstract::Pemphigus is a group of autoimmune diseases characterized by the formation of erosions and/or flaccid bullae of the skin and/or mucosae. The definition "drug-induced pemphigus" has been coined to indicate cases of pemphigus with clinical, histological and immunopathologic features similar to those of the idiopathic di...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/dth.12748

    authors: Palleria C,Bennardo L,Dastoli S,Iannone LF,Silvestri M,Manti A,Nisticò SP,Russo E,De Sarro G

    更新日期:2019-01-01 00:00:00

  • New and emerging biologic therapies for moderate-to-severe plaque psoriasis: mechanistic rationales and recent clinical data for IL-17 and IL-23 inhibitors.

    abstract::The development of effective and well-tolerated biologic therapies has advanced the management of psoriasis by enabling clinicians to treat underlying disease mechanisms. Biologics approved for the treatment of moderate-to-severe psoriasis include three tumor necrosis factor alpha inhibitors and an interleukin-12/inte...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/dth.12251

    authors: Gaspari AA,Tyring S

    更新日期:2015-07-01 00:00:00

  • The use of oral antibiotics in treating acne vulgaris: a new approach.

    abstract::Although acne is not an infectious disease, oral antibiotics have remained a mainstay of treatment over the last 40 years. The anti-inflammatory properties of oral antibiotics, particularly the tetracyclines, are efficacious in treating inflammatory acne lesions. Common prescribing practices in Dermatology exert signi...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/dth.12370

    authors: Farrah G,Tan E

    更新日期:2016-09-01 00:00:00

  • Therapeutic options for chronic hand dermatitis.

    abstract::Hand dermatitis is a common skin condition that often has a chronic and/or relapsing clinical course. Several clinical forms of hand dermatitis have been described, including contact (i.e., allergic and irritant), hyperkeratotic (i.e., psoriasiform or tylotic), frictional, nummular, atopic, pompholyx (i.e., dyshidrosi...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1396-0296.2004.04025.x

    authors: Warshaw EM

    更新日期:2004-01-01 00:00:00

  • Pathogenesis-based therapies in ichthyoses.

    abstract::During the past 20 years, tremendous progress has been made in our understanding of the molecular basis of many genetic skin conditions. The translation of these laboratory findings into effective therapies for affected individuals has been slow, however, in large part due to the risk of carcinogenesis from random vir...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1529-8019.2012.01528.x

    authors: Lai-Cheong JE,Elias PM,Paller AS

    更新日期:2013-01-01 00:00:00

  • Intralesional antigen immunotherapy for the treatment of plane warts: A comparative study.

    abstract::Intralesional immunotherapy by different antigens has shown promising efficacy and safety in the treatment of warts. However, the use of these antigens for the treatment of plane warts has been investigated in two studies only. To evaluate the efficacy and safety of three antigens; Measles Mumps, Rubella vaccine (MMR)...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.13807

    authors: Fawzy MM,Nofal A,Alakad R

    更新日期:2020-11-01 00:00:00

  • Emerging role of nanocarriers based topical delivery of anti-fungal agents in combating growing fungal infections.

    abstract::The incidences of fungal infections have greatly increased over the past few years, particularly in humid and industrialized areas. The severity of such infections ranges from being asymptomatic-mild to potentially life-threatening systemic infections. There are limited classes of drugs that are approved for the treat...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/dth.13905

    authors: Waghule T,Sankar S,Rapalli VK,Gorantla S,Dubey SK,Chellappan DK,Dua K,Singhvi G

    更新日期:2020-11-01 00:00:00

  • Effectiveness of dermabrasion plus 5-fluorouracil vs suction blister in treating vitiligo: A comparative study.

    abstract::Vitiligo is a prevalent destructive melanocyte skin disease that negatively affects the patients' life in terms of self-esteem. Suction blister and dermabrasion plus 5-fluorouracil are effective treatments for vitiligo. The present study was conducted to compare the outcomes of these two techniques. The present clinic...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.14750

    authors: Asilian A,Kazemipour S,Mokhtari F,Iraji F,Shahmoradi Z,Mohaghegh F,Mozafarpoor S,Talakoub M

    更新日期:2021-01-05 00:00:00

  • Infrared-induced adult colloid milium treated with fractionated CO2 laser.

    abstract::Adult colloid milium is a rare cutaneous deposition disorder that frequently involves areas of chronic sun exposure. The most common clinical presentation exhibits multiple, firm, and amber-colored papules that cluster to form large plaques. Histologically, there are masses of amorphous, eosinophilic material expandin...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.12056

    authors: Li YL,Luo YJ,Wu Y,Li B,Gao XH,Chen HD,Li JH

    更新日期:2014-03-01 00:00:00

  • Successful treatment of psoriatic crumbly nails with ustekinumab.

    abstract::Nail involvement can place a significant burden on patients as a result of functional damage and psychosocial problems, leading to major repercussions on the quality of life. There is strong evidence that nail psoriasis can often be difficult to treat. We report a 69-year-old man with severe onychodystrophy, onycholys...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.12914

    authors: Galluzzo M,D'Adamio S,Chimenti MS,Teoli M,Bianchi L,Talamonti M

    更新日期:2019-05-01 00:00:00

  • Treatment of oral lichen planus using 308-nm excimer laser.

    abstract::Oral lichen planus (OLP) is a chronic inflammatory disease, has prolonged courses, repeated attacks and resistance to treatment. The traditional narrow spectrum UVB treatment has an established efficacy on skin lichen planus, and high safety. However, most of ultraviolet phototherapy devices have a huge volume, thereb...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.12510

    authors: Liu WB,Sun LW,Yang H,Wang YF

    更新日期:2017-09-01 00:00:00

  • Topical cidofovir for plantar warts.

    abstract::Plantar warts are a common reason for dermatological consultations and their treatment can occasionally be a challenge. Plantar warts are benign lesions produced by the human papillomavirus (HPV) that often fail to respond to habitual treatment. Cidofovir is a potent antiviral drug that acts competitively, inhibiting ...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.12061

    authors: Padilla España L,Del Boz J,Fernández Morano T,Arenas Villafranca J,de Troya Martín M

    更新日期:2014-03-01 00:00:00

  • Fractional CO2 laser plus topical antifungal versus fractional CO2 laser versus topical antifungal in the treatment of onychomycosis.

    abstract::Onychomycosis is an important medical disorder affecting both health and quality of life of patients. This study was done to compare the efficacy of CO2 laser in combination with topical tioconazole versus CO2 laser only versus topical tioconazole alone in onychomycosis. A total of 120 patients with onychomycosis were...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/dth.13155

    authors: Zaki AM,Abdo HM,Ebadah MA,Ibrahim SM

    更新日期:2020-01-01 00:00:00

  • A comparative study of the effectiveness of cisplatin and 5-fluorouracil on cutaneous squamous human carcinoma cell line: Potential chemotherapy alternative to surgery.

    abstract::Surgery as treatment for local invasive cutaneous squamous cell carcinoma (cSCC) is not always feasible due to the age and/or the health status of patients. Thus, the investigation of new strategies to improve the quality of life of them is required. The aim of this work is to investigate two chemotherapy agents indiv...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.12373

    authors: Gil S,Yébenes M,Luelmo J,Alsina M,Sabés M

    更新日期:2016-09-01 00:00:00