Abstract:
:Hydrogels based on hyaluronic acid are used to restore volume, hydration, and skin tone, as well as to correct scars, asymmetries or defects of the soft tissue. Hyaluronic acid is often chemically crosslinked with different crosslinking agents in order to improve its mechanical and biological properties. Here we focused on defining the chemical and mechanical characterization of a new hydrogel with specific characteristics: hyaluronic acid polyethylene glycol (PEG)-crosslinked with a high concentration of hyaluronic acid (28 mg/mL), manufactured by MatexLab Spa, via Carlo Urbani 2, ang Via Enrico Fermi, Brindisi, Italy. We made a quantitative and qualitative analysis of the content of sodium hyaluronate in the hydrogel after polymerization and sterilization processes and also evaluated histologically the bio integration of these hydrogels in the cutaneous soft tissues. The results suggest that hyaluronic acid hydrogel PEG-crosslinked have great bio integration, great chemical and mechanical properties, compared with other products available on the market, that are cross-linked with different cross-linking agents. The nontoxicity and nonimmunogenicity of PEG guarantee the lack of allergic and immunological reactions. The PEG-crosslinking technology guarantees a high duration time of the implanted hydrogel because of more resistant physiological degradation.
journal_name
Dermatol Therjournal_title
Dermatologic therapyauthors
Zerbinati N,Esposito C,Cipolla G,Calligaro A,Monticelli D,Martina V,Golubovic M,Binic I,Sigova J,Gallo AL,D'Este E,Jafferany M,Pratosoni M,Tirant M,Van Thuong N,Sangalli F,Rauso R,Lotti Tdoi
10.1111/dth.13747subject
Has Abstractpub_date
2020-07-01 00:00:00pages
e13747issue
4eissn
1396-0296issn
1529-8019journal_volume
33pub_type
杂志文章abstract::Keratitis-ichthyosis-deafness (KID syndrome) is a syndromes ichthyoses that is clinically and genetically heterogeneous requiring early and long-term multidisciplinary monitoring of affected individuals. A review of the clinical, etiopathogenic and therapeutic aspects is presented of this rare congenital ectodermal di...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.13507
更新日期:2020-07-01 00:00:00
abstract::Experience at the University of California, San Francisco (UCSF), in the management of patch-stage mycosis fungoides (MF) with topical, predominantly high-potency, corticosteroids is reviewed. The technique of applications is discussed in detail. Approximately 200 patients have been treated. The results are very favor...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1396-0296.2003.01639.x
更新日期:2003-01-01 00:00:00
abstract::It is not common for dermatologists to use intravenous antibiotics in daily practice. However, there are several serious infections that may come to the attention of a dermatologist because of cutaneous signs and symptoms. It is important for dermatologists to be familiar with the presenting symptoms, various stages o...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2012.01533.x
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abstract::Vitiligo progression is attributed to immune system malfunctioning, thus immunomodulating compounds might be beneficial in stopping vitiligo progression which is a prerequisite for successful repigmentation. The goal of this study was to assess efficacy of acridone acetic acid, sodium salt (Na-AAA), an immunomodulatin...
journal_title:Dermatologic therapy
pub_type: 临床试验,杂志文章
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journal_title:Dermatologic therapy
pub_type: 杂志文章
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12096
更新日期:2014-05-01 00:00:00
abstract::Vitiligo is a prevalent destructive melanocyte skin disease that negatively affects the patients' life in terms of self-esteem. Suction blister and dermabrasion plus 5-fluorouracil are effective treatments for vitiligo. The present study was conducted to compare the outcomes of these two techniques. The present clinic...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14750
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journal_title:Dermatologic therapy
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doi:10.1111/dth.14559
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journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12932
更新日期:2019-07-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2005.00030.x
更新日期:2005-07-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/j.1529-8019.2006.00080.x
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abstract::Hand dermatitis is a common skin condition that often has a chronic and/or relapsing clinical course. Several clinical forms of hand dermatitis have been described, including contact (i.e., allergic and irritant), hyperkeratotic (i.e., psoriasiform or tylotic), frictional, nummular, atopic, pompholyx (i.e., dyshidrosi...
journal_title:Dermatologic therapy
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更新日期:2004-01-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
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更新日期:2017-05-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/j.1529-8019.2010.01307.x
更新日期:2010-03-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 信件
doi:10.1111/dth.12830
更新日期:2019-03-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13686
更新日期:2020-09-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12802
更新日期:2019-07-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
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journal_title:Dermatologic therapy
pub_type: 信件
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更新日期:2019-05-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 临床试验,杂志文章
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更新日期:2009-11-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
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journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.14418
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/dth.12793
更新日期:2019-03-01 00:00:00
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