Treatment of COVID-19 with pentoxifylline: Could it be a potential adjuvant therapy?

Abstract:

:The world is facing a viral pandemic of a new coronavirus called COVID-19. Pentoxifylline is a methyl-xanthine derivative and it inhibits the phosphodiesterase IV (PDE IV). This drug is known for its unique features as an immunomodulatory and anti-inflammatory agent, also it could have antiviral affects. This is a scoping review, in which all related articles on COVID-19 and the probable benefits of Pentoxifylline against COVID-19 pathogenesis, in Medline, Scopus, Web of Sciences, and Google Scholar up to 20 March 2020 with proper keywords including: pentoxifylline, Pentoxil, COVID-19, coronavirus, treatment, anti-inflammatory, immunomodulatory, antifibrosis, oxygenation, circulation, bronchodilator, ARDS, and organ failure. We found many confirmatory data on proper efficacy of pentoxifylline on controlling COVID-19 and its consequences. The antiviral, anti-inflammatory, anti-oxidative, immune-modulatory, bronchodilator and respiratory supportive effects and protective roles in organ failures of PTX, along with its main functions means better circulation-oxygenation properties, low price and safety, make it a promising drug to be considered for COVID-19 treatment, especially as an adjuvant therapy in combination with other drugs.

journal_name

Dermatol Ther

journal_title

Dermatologic therapy

authors

Seirafianpour F,Mozafarpoor S,Fattahi N,Sadeghzadeh-Bazargan A,Hanifiha M,Goodarzi A

doi

10.1111/dth.13733

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

e13733

issue

4

eissn

1396-0296

issn

1529-8019

journal_volume

33

pub_type

杂志文章,评审
  • A retrospective, observational multicenter study of 141 patients treated with ustekinumab 90 mg.

    abstract::A change of pricing policy in Spain have made both doses of ustekinumab (UST), 45 and 90 mg, recently available at the same price. Our primary objective was to evaluate effectiveness of UST 90 mg at 52 and 104 weeks in psoriasis patients in clinical practice; secondary objectives were to study the reasons for using th...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.13678

    authors: Llamas-Velasco M,Baniandrés O,Rivera R,Reymundo Jimenez A,Hospital M,García Zamora E,González-Cantero Á,Andrés Lencina JJ,Daudén E,de la Cueva P

    更新日期:2020-07-01 00:00:00

  • Aberrant expression of cell-free nucleosomes in dermatomyositis/polymyositis.

    abstract::Nucleosomes are typically located intracellularly, and extracellular levels of nucleosomes indicated the degree of cell death. We postulated aberrant nucleosomes expression in dermatomyositis (DM) and polymyositis (PM). To assess the aberrant expression of circulating nucleosomes in DM and polymyositis. 76 consecutive...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.14460

    authors: Zhong D,Wu C,Bai J,Zhao J,Xu D,Li M,Wang Q,Wang F,Zeng X

    更新日期:2020-11-01 00:00:00

  • A patient with delusional infestation by proxy: Issues for vulnerable adults.

    abstract::A 57-year-old Caucasian female presented to our clinic with her 23-year-old son, who was profoundly autistic. Our patient was convinced that her son had an infestation with fibers and believed that he had developed the condition as a young child. She described the symptoms of the infestation in her son's skin on his b...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.12724

    authors: Hussain K,Gkini MA,Taylor R,Shinhmar S,Bewley A

    更新日期:2018-11-01 00:00:00

  • Treatment of pruritus in early-stage hypopigmented mycosis fungoides with aprepitant.

    abstract::Pruritus is a symptom that significantly affects the patient's quality of life in cutaneous T cell lymphoma (CTCL). The most effective treatments are those that address the condition itself; however, it is often not possible to control this symptom. Lymphoma-related pruritus normally becomes more severe as CTCL progre...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.12113

    authors: Jiménez Gallo D,Albarrán Planelles C,Linares Barrios M,Fernández Anguita MJ,Márquez Enríquez J,Rodríguez Mateos ME

    更新日期:2014-05-01 00:00:00

  • Therapeutic options in vitiligo with special emphasis on immunomodulators: A comprehensive update with review of literature.

    abstract::Vitiligo is a relatively common disorder characterized by areas of depigmented skin. It may be associated with social stigma and adversely affects the quality of life. Although many treatment options are available, none is curable. The search continues for an effective therapeutic option. New targeted options include ...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/dth.13215

    authors: Agarwal K,Podder I,Kassir M,Vojvodic A,Schwartz RA,Wollina U,Valle Y,Lotti T,Rokni GR,Grabbe S,Goldust M

    更新日期:2020-03-01 00:00:00

  • Update on retinoid therapy of psoriasis in: an update on the use of retinoids in dermatology.

    abstract::Both in the topical and systemic treatment of psoriasis, retinoids are mainstays. In this chapter the history and modes of actions of retinoids are presented. Tazarotene and acitretin are the only retinoids that are available in both topical and systemic formulations. A more extensive description of their pharmacology...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1529-8019.2006.00082.x

    authors: van de Kerkhof PC

    更新日期:2006-09-01 00:00:00

  • Recalcitrant trametinib-induced paronychia treated successfully with topical timolol in a pediatric patient.

    abstract::Paronychia has been described as a side effect in patients undergoing treatment with MEK (mitogen activated protein kinase enzyme) inhibitors. It is usually a recurrent condition that can have a significant impact in the quality of life. Topical beta blocker treatment has been described as an effective therapy in anti...

    journal_title:Dermatologic therapy

    pub_type: 信件

    doi:10.1111/dth.13164

    authors: Martínez-de-Espronceda I,Bernabeu-Wittel J,Azcona M,Monserrat MT

    更新日期:2020-01-01 00:00:00

  • Cutaneous melanoma and intervention strategies to reduce tumor-related mortality: what we know, what we don't know, and what we think we know that isn't so.

    abstract::The care of patients who have cutaneous melanoma (CM) has undergone a dramatic change during the past five decades. In an increasing majority of cases, CM is being discovered in a premetastatic phase of tumor progression. Most patients are being treated in the ambulatory setting with a minimum of inconvenience and eco...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1529-8019.2005.00056.x

    authors: Rhodes AR

    更新日期:2006-01-01 00:00:00

  • Long-term efficacy of up to 15 months' efalizumab therapy in patients with moderate-to-severe chronic plaque psoriasis.

    abstract::The efficacy and safety of efalizumab in the treatment of moderate-to-severe chronic psoriasis has been established in studies of up to 3 years' duration. This study aims to describe the efficacy of up to 15 months' treatment with efalizumab and the convenience of therapy in patients with moderate-to-severe chronic pl...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1529-8019.2008.00235.x

    authors: Toth DP,Papp K,Gratton D

    更新日期:2008-11-01 00:00:00

  • The treatment of ingrown nail: Chemical matricectomy with NAOH versus wedge resection.

    abstract::Ingrown nail is a common problem seen in the dermatology clinics. The aim of this study is to compare the wedge resection method and chemical matricectomy with NaOH in terms of operation time, postoperative pain severity, postoperative drainage, recurrence rates, recovery time, and the effects of these two methods on ...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/dth.12677

    authors: Akkus A,Demirseren DD,Demirseren ME,Aktas A

    更新日期:2018-09-01 00:00:00

  • Daylight methyl-aminolevulinate photodynamic therapy versus ingenol mebutate for the treatment of actinic keratoses: an intraindividual comparative analysis.

    abstract::Daylight-photodynamic therapy (D-PDT) and ingenol mebutate (IM) are novel therapies directed to actinic keratoses (AK). The purpose of our study was to compare effectiveness, tolerability, cosmetic outcome and patient preference of D-PDT versus IM in the treatment of grade I and II AK. Twenty-seven patients with AK on...

    journal_title:Dermatologic therapy

    pub_type: 临床试验,杂志文章

    doi:10.1111/dth.12334

    authors: Genovese G,Fai D,Fai C,Mavilia L,Mercuri SR

    更新日期:2016-05-01 00:00:00

  • Clinical efficacy of dialkylcarbamoylchloride-coated cotton acetate dressing versus combination of normal saline dressing and 2% mupirocin ointment in infected wounds of epidermolysis bullosa.

    abstract::Dialkylcarbamoylchloride (DACC)-coated cotton acetate dressing works directly through hydrophobic interaction to reduce the number of bacteria without the risk of resistance. It is easy to use and therefore expected to improve patient's compliance. This study aimed to assess the clinical efficacy of DACC-coated cotton...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.13047

    authors: Dwiyana RF,Gondokaryono SP,Rahardja JI,Arline Diana I,Yogya Y,Gunawan H

    更新日期:2019-09-01 00:00:00

  • Cutaneous necrotizing vasculitis: a rational therapeutic approach.

    abstract::Cutaneous necrotizing vasculitis is a heterogeneous group of disorders characterized clinically by palpable purpura, and histologically by a segmental angiocentric inflammatory condition with fibrinoid necrosis of the vessel wall, endothelial swelling, and nuclear dust of the post capillary venules. Often, the skin se...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/j.1529-8019.2012.01480.x

    authors: Tsampau D,Buggiani G,Hercogova J,Lotti T

    更新日期:2012-07-01 00:00:00

  • The efficacy of fractional ablative carbon dioxide laser combined with other therapies in acne scars.

    abstract::Fractional ablative carbon dioxide laser resurfacing is a frontline treatment for acne scars. It creates multiple microscopic treatment zones to accelerate the collagen formation and the healing process of reepithelialization, according the principle of fractional photothermolysis. At present, the fractional CO2 laser...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/dth.13084

    authors: Mu YZ,Jiang L,Yang H

    更新日期:2019-11-01 00:00:00

  • Efficacy of oral retinoids for keratoacanthoma centrifugum marginatum.

    abstract::Keratoacanthoma centrifugum marginatum (KCM) is a rare variant of keratoacanthoma. This condition is difficult to diagnose because of its large size and expansive nature and may be diagnosed as a malignant tumor. There are various treatments such as surgery and oral retinoids; however, limited studies have verified th...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.13291

    authors: Mizuta H,Takahashi A,Mori T,Namikawa K,Nakano E,Muto Y,Jinnai S,Nakama K,Tsutsui K,Yamazaki N

    更新日期:2020-05-01 00:00:00

  • Pitfall prayer marks: Recognition and appropriate treatment: A case report and review of literature.

    abstract::Prayer marks are asymptomatic callosities resulting from repeated, extended pressure, and friction exerted on bony prominences when praying on hard ground. A 41-year-old woman with ulcerative colitis treated with infliximab was referred to our clinic due to skin changes on her feet that were suspected to be drug erupt...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/dth.13176

    authors: Fosse N,Rast AC,Kammermann A,Sonderegger J,Navarini A,Goldust M,Brandt O,Mueller SM

    更新日期:2020-01-01 00:00:00

  • New and emerging biologic therapies for moderate-to-severe plaque psoriasis: mechanistic rationales and recent clinical data for IL-17 and IL-23 inhibitors.

    abstract::The development of effective and well-tolerated biologic therapies has advanced the management of psoriasis by enabling clinicians to treat underlying disease mechanisms. Biologics approved for the treatment of moderate-to-severe psoriasis include three tumor necrosis factor alpha inhibitors and an interleukin-12/inte...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/dth.12251

    authors: Gaspari AA,Tyring S

    更新日期:2015-07-01 00:00:00

  • Efficacy of electrochemotherapy for eruptive legs keratoacanthomas.

    abstract::Generalized eruptive keratoacanthoma, is considered a serious condition because the eruptions are diffuse, persistent, and recurrent. Constant pruritus, visceral neoplasms, and unsatisfactory response to treatment are ominous prognostic factors. Even if skin cancers are usually well controlled with surgical and/or rad...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.12374

    authors: Ribero S,Balagna E,Sportoletti Baduel E,Picciotto F,Sanlorenzo M,Fierro MT,Quaglino P,Macripo G

    更新日期:2016-09-01 00:00:00

  • Mechanism of Oleogel-S10: A triterpene preparation for the treatment of epidermolysis bullosa.

    abstract::Epidermolysis bullosa (EB) is a group of rare heterogeneous, genetic disorders. Currently, there is no effective pharmacological or genetic therapy for all EB subtypes. Dry extract from birch bark and betulin upregulate some pro-inflammatory mediators and downregulate others. The increase in pro-inflammatory cytokines...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/dth.12983

    authors: Schwieger-Briel A,Ott H,Kiritsi D,Laszczyk-Lauer M,Bodemer C

    更新日期:2019-07-01 00:00:00

  • Treatment of patch-stage mycosis fungoides with topical corticosteroids.

    abstract::Experience at the University of California, San Francisco (UCSF), in the management of patch-stage mycosis fungoides (MF) with topical, predominantly high-potency, corticosteroids is reviewed. The technique of applications is discussed in detail. Approximately 200 patients have been treated. The results are very favor...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1396-0296.2003.01639.x

    authors: Zackheim HS

    更新日期:2003-01-01 00:00:00

  • Clinical evaluation of the efficacy and safety of fractional bipolar radiofrequency for the treatment of moderate to severe acne scars.

    abstract::Several treatment modalities are used for the treatment of acne scars with variable results. Recent studies showed that fractional radiofrequency may be an effective treatment modality for acne scars. The objective of this study was to assess the efficacy, safety, tolerability and patient satisfaction of fractional bi...

    journal_title:Dermatologic therapy

    pub_type: 临床试验,杂志文章

    doi:10.1111/dth.12275

    authors: Verner I

    更新日期:2016-01-01 00:00:00

  • Urticarial rash, fever, and arthritis: A case of refractory Adult-onset Still's disease with good response to tocilizumab.

    abstract::Adult-onset Still's disease (AOSD) is a rare, systemic inflammatory disorder of not completely understood etiology. Aberrant activation of the innate immune system and overproduction of several pro-inflammatory mediators are considered a critical component in disease pathogenesis. AOSD still poses a challenge due to t...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/dth.13041

    authors: Wawrzycki B,Krasowska D,Pietrzak A,Wielosz E,Majdan M,Lotti T

    更新日期:2019-09-01 00:00:00

  • Luliconazole-loaded nanostructured lipid carriers for topical treatment of superficial Tinea infections.

    abstract::Tinea are superficial fungal infections caused by dermatophytes. Luliconazole exhibits highest antifungal activity against Trichophyton spp. which are major causative agents of dermatophytosis. However, luliconazole suffers from drawbacks such as less skin retention, low aqueous solubility and poor skin penetration. T...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.13959

    authors: Baghel S,Nair VS,Pirani A,Sravani AB,Bhemisetty B,Ananthamurthy K,Aranjani JM,Lewis SA

    更新日期:2020-11-01 00:00:00

  • Improving aseptic injection standards in aesthetic clinical practice.

    abstract::The rise in popularity and demand for nonsurgical injectable aesthetic procedures is inherently accompanied by an increase in reported complications, particularly those related to infection. Aseptic technique is under the control of aesthetic practitioners and can be modified to minimize the potential for cross-contam...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/dth.14416

    authors: Murthy R,Eccleston D,Mckeown D,Parikh A,Shotter S

    更新日期:2020-10-17 00:00:00

  • Topical and oral bexarotene.

    abstract::Bexarotene is a retinoid that specifically binds retinoid X receptors and has numerous effects on cellular growth and differentiation. It is approved for the treatment of cutaneous T cell lymphoma both topically and systemically. Adverse effects include hyperlipidemia, central hypothyroidism, and neutropenia with bexa...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.12087

    authors: Schadt CR

    更新日期:2013-09-01 00:00:00

  • Efalizumab in the treatment of psoriasis: when comorbidity is an issue.

    abstract::Psoriasis is a common dermatosis affecting the skin, mucosal surfaces, and cutaneous adnexa, and joints and bones can be involved at some degree in the clinical features of the disease, configuring psoriatic arthritis. Moderate to severe psoriasis has a high impact on quality of life and requires an integrated and lon...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/j.1529-8019.2008.00229.x

    authors: Prignano F,Buggiani G,Lotti T

    更新日期:2008-10-01 00:00:00

  • Management of pediatric psoriasis with acitretin: A review.

    abstract::Psoriasis is a chronic inflammatory disease of the skin which can occur at any age-group. Psoriasis in childhood is not uncommon and has genetic susceptibility but usually, an environmental trigger such as infection is thought to initiate the disease process. Pediatric psoriasis has profound effects on both physical a...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/dth.12571

    authors: Subedi S,Yu Q,Chen Z,Shi Y

    更新日期:2018-01-01 00:00:00

  • Androgens and hair growth.

    abstract::Hair's importance in human communication means that abnormalities like excess hair in hirsutism or hair loss in alopecia cause psychological distress. Androgens are the main regulator of human hair follicles, changing small vellus follicles producing tiny, virtually invisible hairs into larger intermediate and termina...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1529-8019.2008.00214.x

    authors: Randall VA

    更新日期:2008-09-01 00:00:00

  • Activation of Janus kinase signaling pathway in acne lesions.

    abstract::The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway has been linked to the pathogenesis of many inflammatory skin diseases; however, the role of JAKs in the pathogenesis of acne vulgaris has not been previously elucidated. We aimed to analyze the cutaneous expression of JAK1/...

    journal_title:Dermatologic therapy

    pub_type: 杂志文章

    doi:10.1111/dth.14563

    authors: Awad SM,Tawfik YM,El-Mokhtar MA,El-Gazzar AF,Abdel Motaleb AA

    更新日期:2020-11-19 00:00:00

  • Oral minocycline in the treatment of vitiligo--a preliminary study.

    abstract::For effective treatment of vitiligo, it is as important to arrest the progression of the disease, as it is to induce repigmentation. Epidermal oxidative stress has been documented in vitiligo patients, and there is much support for a free-radical-mediated damage as an initial pathogenic event in melanocyte degeneratio...

    journal_title:Dermatologic therapy

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1529-8019.2010.01328.x

    authors: Parsad D,Kanwar A

    更新日期:2010-05-01 00:00:00