Efficacy of oral retinoids for keratoacanthoma centrifugum marginatum.

Abstract:

:Keratoacanthoma centrifugum marginatum (KCM) is a rare variant of keratoacanthoma. This condition is difficult to diagnose because of its large size and expansive nature and may be diagnosed as a malignant tumor. There are various treatments such as surgery and oral retinoids; however, limited studies have verified their effectiveness. Here, we report a case of KCM on the anterior chest of a 50-year-old woman and evaluate the efficacy of oral retinoids. In this case, oral retinoids were highly effective for KCM treatment. A total of 55 cases of KCM, including 54 previously reported cases, were reviewed, and their clinical characteristics and treatment were examined. In this report, 14 of 16 patients were effectively treated with oral retinoids, resulting in a treatment rate of 87.5%. Furthermore, even low-to-medium doses were sufficient for treatment and prevention. KCM can be misdiagnosed as a malignant disease based on its clinical features. Due to its large size and expansive nature, a wide excision may be performed; however, because oral retinoids have a very high response rate, an accurate diagnosis will help avoid an unnecessary wide excision.

journal_name

Dermatol Ther

journal_title

Dermatologic therapy

authors

Mizuta H,Takahashi A,Mori T,Namikawa K,Nakano E,Muto Y,Jinnai S,Nakama K,Tsutsui K,Yamazaki N

doi

10.1111/dth.13291

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

e13291

issue

3

eissn

1396-0296

issn

1529-8019

journal_volume

33

pub_type

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