Long-term efficacy of up to 15 months' efalizumab therapy in patients with moderate-to-severe chronic plaque psoriasis.

Abstract:

:The efficacy and safety of efalizumab in the treatment of moderate-to-severe chronic psoriasis has been established in studies of up to 3 years' duration. This study aims to describe the efficacy of up to 15 months' treatment with efalizumab and the convenience of therapy in patients with moderate-to-severe chronic plaque psoriasis. Patients who had completed a 3-month, double-blind, randomized, placebo-controlled, Phase IIIb trial entered a 12-month extension study and received efalizumab, 1 mg/kg/week administered subcutaneously, for up to 12 months. Of 450 patients originally randomly assigned to receive efalizumab, 40.9% achieved a reduction of > or = 75% in the Psoriasis Area and Severity Index score after 15 months of treatment. Improvements were also observed on the frequency and severity subscales of the Psoriasis Symptom Assessment. The majority of patients reported that efalizumab treatment was more or much more convenient than other psoriasis treatments. Efalizumab, 1 mg/kg/week, provides long-term efficacy and good convenience with up to 15 months of continuous treatment.

journal_name

Dermatol Ther

journal_title

Dermatologic therapy

authors

Toth DP,Papp K,Gratton D

doi

10.1111/j.1529-8019.2008.00235.x

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

S6-14

eissn

1396-0296

issn

1529-8019

pii

DTH235

journal_volume

21 Suppl 3

pub_type

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