Omalizumab for treatment of refractory severe atopic dermatitis. A pediatric perspective.

Abstract:

:Omalizumab is a monoclonal antibody, targeting Fc receptor of IgE, approved for the treatment of allergic asthma and chronic spontaneous urticaria. Its utility in atopic dermatitis appears controversial from data in literature since the molecule is well tolerated but it seems less effective than other medications used in adult patients (eg, Dupilumab). At present, the use of Dupilumab is not approved in pediatric patients therefore there are no second level treatments available in this age group. Here we report two clinical cases of patients (15 and 16 years old) suffering from both atopic dermatitis and asthma, treated with Omalizumab. Our experience suggests that atopic eczema of young patients with allergic comorbidities can benefit from asthma treatment with Omalizumab observing improvement on both conditions.

journal_name

Dermatol Ther

journal_title

Dermatologic therapy

authors

Iannelli M,Caminiti L,Vaccaro M,Marafioti I,Spinuzza A,Panasiti I,Barbalace A,Crisafulli G,Pajno GB

doi

10.1111/dth.13519

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

e13519

issue

4

eissn

1396-0296

issn

1529-8019

journal_volume

33

pub_type

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