Treatment of severe psoriasis with ixekizumab in a liver transplant recipient with concomitant hepatitis B virus infection.

Abstract:

:Treatment of severe psoriasis (PsO) in organ transplant (OT) patients is difficult. In fact, systemic drugs used for PsO therapy can be detrimental to transplanted organs and/or can increase the risk of serious infections in subjects already taking antireject medicines. Current guidelines fail to give indications on how to manage PsO OT subjects. Moreover, only a few cases of patients with the above-cited characteristics treated with systemic therapies have been published so far. Here, we report our experience concerning a liver transplant patient successfully treated with ixekizumab for his psoriasis throughout 1 year.

journal_name

Dermatol Ther

journal_title

Dermatologic therapy

authors

Lora V,Graceffa D,De Felice C,Morrone A,Bonifati C

doi

10.1111/dth.12909

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

e12909

issue

3

eissn

1396-0296

issn

1529-8019

journal_volume

32

pub_type

信件
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    abstract::Psoriasis and psoriatic arthritis (PsA) have been linked to metabolic syndrome (MS). The impact of adipokines on psoriasis, PsA, and MS pathogenesis has recently received investigative attention. A total of 80 subjects with psoriasis, 40 subjects with PsA, and 60 healthy controls were enrolled. Serum omentin and visfa...

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  • Reduced doses of biological therapies in psoriasis may increase efficiency without decreasing drug survival.

    abstract::Off-label treatment with reduced doses of biological therapies for moderate-severe psoriasis is used, but its efficacy, safety, and persistence are not well known. We have compared reduced doses with standard an escalated doses and study predictive factors for a successful reduction of doses lasting more than 6 months...

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