Abstract:
:Switching psoriasis treatment is a common, accepted practice that is used to improve disease management and improve patient outcomes (e.g., when patients are experiencing suboptimal efficacy and/or tolerability with a given therapy). Historically, switching treatment was often performed to limit patients' cumulative exposure to conventional systemic agents (e.g., methotrexate, cyclosporine) with the goal of reducing end-organ toxicity. However, the practice of switching treatments has evolved in recent years with the availability of highly effective and tolerable biologic agents. In current practice, near-complete skin clearance with minimal side effects should be a realistic treatment goal for most patients with moderate-to-severe psoriasis, and consideration for switching therapies has shifted to become more focused on achieving maximum possible skin clearance, enhanced quality of life, and improved patient satisfaction. This review provides a discussion of recent guidance on switching psoriasis therapies, including initial considerations for when switching therapy may be advisable and challenges associated with switching therapy, along with an overview of published clinical studies evaluating outcomes associated with switching therapy. The goal of this review is to empower dermatologists to optimally manage their patients' psoriasis by providing the tools needed to develop rational strategies for switching treatments based on the pharmacologic characteristics of available treatments and each patient's clinical needs and treatment preferences.
journal_name
Dermatol Therjournal_title
Dermatologic therapyauthors
Kerdel F,Zaiac Mdoi
10.1111/dth.12267subject
Has Abstractpub_date
2015-11-01 00:00:00pages
390-403issue
6eissn
1396-0296issn
1529-8019journal_volume
28pub_type
杂志文章,评审abstract::For effective treatment of vitiligo, it is as important to arrest the progression of the disease, as it is to induce repigmentation. Epidermal oxidative stress has been documented in vitiligo patients, and there is much support for a free-radical-mediated damage as an initial pathogenic event in melanocyte degeneratio...
journal_title:Dermatologic therapy
pub_type: 临床试验,杂志文章
doi:10.1111/j.1529-8019.2010.01328.x
更新日期:2010-05-01 00:00:00
abstract::Daylight-photodynamic therapy (D-PDT) and ingenol mebutate (IM) are novel therapies directed to actinic keratoses (AK). The purpose of our study was to compare effectiveness, tolerability, cosmetic outcome and patient preference of D-PDT versus IM in the treatment of grade I and II AK. Twenty-seven patients with AK on...
journal_title:Dermatologic therapy
pub_type: 临床试验,杂志文章
doi:10.1111/dth.12334
更新日期:2016-05-01 00:00:00
abstract::For many years, drug therapies were not explicitly studied in the pediatric population. The lack of data forced clinicians to treat children using empiric therapy, often guessing at the treatment dose. In addition to the lack of dosing information, there was no evidence that a product would be safe and efficacious in ...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2009.01239.x
更新日期:2009-05-01 00:00:00
abstract::Although there is still some controversy about the existence of psoriatic arthritis as a specific form of inflammatory arthritis associated with psoriasis, epidemiological, and clinical studies support the unique features of psoriatic arthritis. Because of lack of diagnostic or classification criteria, the disease has...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1396-0296.2004.04038.x
更新日期:2004-01-01 00:00:00
abstract::Dermoscopy as a diagnostic tool is attaining impetus in inflammatory dermatoses with the cumulative description of characteristic findings in most dermatoses obviating at times the need of biopsy. In this retrospective observational study, 20 histopathology confirmed cases each of pityriasis rosea (PR), guttate psoria...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14631
更新日期:2020-12-05 00:00:00
abstract::In view of the new viral COVID-19 pandemic, the fungal Candida auris epidemic still in progress worldwide highlights non-Candida albicans candidal infections. We describe an immunocompetent woman with a cutaneous manifestation of Candida parasilopsis fungemia, a prominent eschar, which proved to be the nidus for the c...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13481
更新日期:2020-07-01 00:00:00
abstract::Isotretinoin is a safe and useful medication for acne management. Adverse effects are mostly related to cutaneous and mucous membranes. We present a case of a 24-year-old female patient who was on treatment with isotretinoin for acne vulgaris Grade 4. After 6 months of treatment, the patient presented with localized p...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13280
更新日期:2020-05-01 00:00:00
abstract::Epidermolysis Bullosa (EB) is a rare group of diseases caused by genetic variants in skin structural proteins. EB is characterized by varying degrees of skin fragility, blisters and impaired wound healing, and is classified based on the ultrastructural levels of skin cleavage-simplex, junctional, dystrophic, and Kindl...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14093
更新日期:2020-11-01 00:00:00
abstract::Intralesional immunotherapy by different antigens has shown promising efficacy and safety in the treatment of warts. However, the use of these antigens for the treatment of plane warts has been investigated in two studies only. To evaluate the efficacy and safety of three antigens; Measles Mumps, Rubella vaccine (MMR)...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13807
更新日期:2020-11-01 00:00:00
abstract::Atopic dermatitis is an extremely common childhood skin disease that can have far-reaching impact on patients and families. Pediatric patients, particularly infants, pose special concerns for parents and providers, and equal emphasis must be placed on both nonpharmacologic and prescription interventions. Concerns for ...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2006.00061.x
更新日期:2006-03-01 00:00:00
abstract::Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous reactions that are medication-induced in most instances. While the clinical manifestations of SJS and TEN are well-defined, the optimal treatment for these disorders is not. Case reports have shown benefit with the use of a variet...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2011.01396.x
更新日期:2011-03-01 00:00:00
abstract::Vitiligo is a systemic disease that affects not only the skin but also other areas that contain melanocytes, such as the inner ear. Studies of the effect of vitiligo on hearing loss have shown inconsistent results, and it is not clear which parameters related to the disease affect hearing. The aim of this study was to...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13724
更新日期:2020-07-01 00:00:00
abstract::Duct tape occlusive therapy may represent a convenient alternative to the standard wart therapies. The objective of the current study is to assess the therapeutic effect of duct tape occlusion in comparison to cryotherapy in treatment of plantar warts in adults, in a prospective comparative randomized non-inferiority ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13342
更新日期:2020-05-01 00:00:00
abstract::Androgenetic alopecia also known as pattern alopecia, is a disorder characterized by the gradual onset of the conversion of terminal hairs into vellus hairs. Dexpanthenol has an anti-oxidative and anti-inflammatory effect and a cellular repair capability. We present nine male cases who had marked improvement after rec...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13381
更新日期:2020-05-01 00:00:00
abstract::Bexarotene is a retinoid that specifically binds retinoid X receptors and has numerous effects on cellular growth and differentiation. It is approved for the treatment of cutaneous T cell lymphoma both topically and systemically. Adverse effects include hyperlipidemia, central hypothyroidism, and neutropenia with bexa...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12087
更新日期:2013-09-01 00:00:00
abstract::The isotretinoin registry has arrived. It has a lofty goal of preventing all isotretinoin pregnancies. How we got to this point and what the registry means to prescribers and patients have many dermatologists confused and concerned. Will it be burdensome, will it preclude the use in most offices of this most important...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/j.1529-8019.2006.00080.x
更新日期:2006-07-01 00:00:00
abstract::Although acne is not an infectious disease, oral antibiotics have remained a mainstay of treatment over the last 40 years. The anti-inflammatory properties of oral antibiotics, particularly the tetracyclines, are efficacious in treating inflammatory acne lesions. Common prescribing practices in Dermatology exert signi...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.12370
更新日期:2016-09-01 00:00:00
abstract::Acitretin has been used off-label for years to treat chronic hand eczema, but acitretin is less often prescribed as alitretinoïne was approved. This study evaluates both retinoids in a daily practice cohort of patients with severe chronic hand eczema in terms of drug survival and reasons for discontinuation. Patients ...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12362
更新日期:2016-09-01 00:00:00
abstract::Vitiligo is quite a common hypopigmentary disorder, which may affect both children and adults with important psychological effects due to the well-known leopard skin-like appearance. The authors summarize in the present study the published evidence on vitiligo with particular interest on the controversial aspects of t...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.12745
更新日期:2019-01-01 00:00:00
abstract::The Coronavirus Disease 2019 (COVID-19) outbreak significantly affected the clinical practice in hospitals and the management of many diseases. The aim of this study was to evaluate the effect of pandemic-related factors on the severity and course of chronic urticaria (CU). A total of 194 CU patients who were on regul...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14652
更新日期:2020-12-10 00:00:00
abstract::Keloid often recur after treatment, and recent studies in keloid management favor the combination therapy of laser-assisted drug delivery over monotherapy. Unfortunately, the previous researches lack long-term follow-up. In this prospective study, 41 individuals with refractory keloids underwent eight treatment sessio...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14359
更新日期:2020-11-01 00:00:00
abstract::The World Health Organization has recently defined the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections as a pandemic. The infection, which may cause a potentially very severe respiratory disease, now called coronavirus disease 2019 (COVID-19), has airborne transmission via droplets while less a...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13777
更新日期:2020-09-01 00:00:00
abstract::This study evaluated the efficacy and tolerability of topical aluminum sesquichlorohydrate (AS) when compared to aluminum chloride (AC) as a treatment for primary axillary hyperhidrosis (PAH). Twenty subjects were included in this randomized, controlled, split-side 8-week study. All participants applied 20% AS and 20%...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14354
更新日期:2020-11-01 00:00:00
abstract::Acne is known as a chronic inflammatory skin disease with sever adverse effects on quality of life in the patients. The increasing resistance to antibiotics has decreased their effectiveness in treating acne. As viable microbial dietary supplements, probiotics provide health benefits through fighting pathogens and mai...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.13279
更新日期:2020-05-01 00:00:00
abstract::Psoriasis and psoriatic arthritis (PsA) have been linked to metabolic syndrome (MS). The impact of adipokines on psoriasis, PsA, and MS pathogenesis has recently received investigative attention. A total of 80 subjects with psoriasis, 40 subjects with PsA, and 60 healthy controls were enrolled. Serum omentin and visfa...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14378
更新日期:2020-11-01 00:00:00
abstract::Febrile ulcero-necrotic Mucha-Habermann disease (FUMHD) is a rare subtype of pityriasis lichenoides et varioliformis acuta (only 41 cases described to date), characterized by an acute onset of ulcero-necrotic papules accompanied by high fever and severe constitutional symptoms. We report a case of a 23-year-old man wi...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/j.1529-8019.2010.01343.x
更新日期:2010-07-01 00:00:00
abstract::The present authors report the case of a 9-year-old boy affected by psoriasis, juvenile psoriatic arthritis, enthesitis, and celiac disease. The signs and symptoms of the different comorbidities appeared at different times in the clinical history, complicating the overall diagnostic and therapeutic procedures. Coopera...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/j.1529-8019.2010.01301.x
更新日期:2010-03-01 00:00:00
abstract::Physicians and patients have come to expect that our prescription topicals not only be efficacious but also minimally irritating and cosmetically pleasing. Much research and development effort are being spent to identify new vehicles to achieve these goals. Consumers are also demanding nonprescription products that gi...
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2012.01501.x
更新日期:2012-05-01 00:00:00
abstract::Maffucci syndrome is characterized by multiple benign vascular anomalies and enchondromas present on the distal extremities. Effective treatment options are currently not available for Maffucci syndrome-associated vascular lesions. Sirolimus is a mTOR pathway inhibitor, and has been tried successfully in the treatment...
journal_title:Dermatologic therapy
pub_type: 信件
doi:10.1111/dth.12851
更新日期:2019-05-01 00:00:00
abstract::Psoriasis of the scalp, face, intertriginous areas, genitals, hands, feet, and nails is often underdiagnosed, and disease management can be challenging. Despite the small surface area commonly affected by psoriasis in these locations, patients have disproportionate levels of physical impairment and emotional distress....
journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.12589
更新日期:2018-05-01 00:00:00