Abstract:
:Pruritus is a symptom that significantly affects the patient's quality of life in cutaneous T cell lymphoma (CTCL). The most effective treatments are those that address the condition itself; however, it is often not possible to control this symptom. Lymphoma-related pruritus normally becomes more severe as CTCL progresses, constituting an important factor for quality of life in these patients. Substance P is a neuromodulator which appears to play a key role in pruritus. Aprepitant is a neurokinin-1 receptor antagonist affecting the substance P receptor. So far, several cases have been documented with an antipruritic response to the drug aprepitant in advanced-stage mycosis fungoides (MF). In this paper, we describe an excellent response to aprepitant in a female patient with severe pruritus secondary to hypopigmented stage I MF. We would also like to stress the absence of nausea and vomiting of this combined therapy of interferon and aprepitant. Aprepitant could improve tolerance to interferon.
journal_name
Dermatol Therjournal_title
Dermatologic therapyauthors
Jiménez Gallo D,Albarrán Planelles C,Linares Barrios M,Fernández Anguita MJ,Márquez Enríquez J,Rodríguez Mateos MEdoi
10.1111/dth.12113subject
Has Abstractpub_date
2014-05-01 00:00:00pages
178-82issue
3eissn
1396-0296issn
1529-8019journal_volume
27pub_type
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