Cutaneous necrotizing vasculitis: a rational therapeutic approach.

Abstract:

:Cutaneous necrotizing vasculitis is a heterogeneous group of disorders characterized clinically by palpable purpura, and histologically by a segmental angiocentric inflammatory condition with fibrinoid necrosis of the vessel wall, endothelial swelling, and nuclear dust of the post capillary venules. Often, the skin seems the only organ apparently damaged, but systemic involvement may occur. In up to 60% of cases of cutaneous necrotizing vasculitis, the cause remains unknown; in others, it may be due to a variety of underlying conditions such as drugs, chemicals, food allergens, infections, chronic inflammatory systemic disorders, or malignant neoplasms. A rational therapeutic approach of vasculitis begins with the identification and stoppage of any suspected underlying condition. This may be all that is required for the treatment, because it is usually followed by the clearing of cutaneous lesions, and systemic signs and symptoms. In other cases, local and/or systemic anti-inflammatory and/or immunosuppressive therapy is recommended.

journal_name

Dermatol Ther

journal_title

Dermatologic therapy

authors

Tsampau D,Buggiani G,Hercogova J,Lotti T

doi

10.1111/j.1529-8019.2012.01480.x

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

335-9

issue

4

eissn

1396-0296

issn

1529-8019

journal_volume

25

pub_type

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