Abstract:
:Pustulosis palmoplantaris (PPP; synonyms: pustulosis palmaris et plantaris, palmoplantar amicrobic pustulosis) is a common chronic, relapsing, pustular eruption affecting the palms and soles. The authors report the successful treatment of six therapy-experienced patients with histologically confirmed PPP with oral itraconazole (100 mg/day for 1 month, followed by a month of 100 mg/day every other day). Three of six patients showed complete clearance of pustules, significant reduction of erythema, and unnoticeable desquamation, whereas the other three patients had no new pustules appearing and had modest reduction of erythema and desquamation. All patients experienced relapses within a month of therapy cessation. Two of the three complete responders reinitiated itraconazole therapy at 100 mg/day for another 2 weeks, followed by a maintenance dose of 50 mg/day until achieving remission. As complete responses are not commonly observed in placebo treatments in placebo-controlled trials for PPP, the authors believe that the present study shows that itraconazole is an effective treatment for treatment-resistant PPP.
journal_name
Dermatol Therjournal_title
Dermatologic therapyauthors
V'lckova-Laskoska MT,Caca-Biljanovska NG,Laskoski DS,Kamberova SJdoi
10.1111/j.1529-8019.2008.01219.xsubject
Has Abstractpub_date
2009-01-01 00:00:00pages
85-9issue
1eissn
1396-0296issn
1529-8019pii
DTH1219journal_volume
22pub_type
临床试验,杂志文章abstract::Although there is still some controversy about the existence of psoriatic arthritis as a specific form of inflammatory arthritis associated with psoriasis, epidemiological, and clinical studies support the unique features of psoriatic arthritis. Because of lack of diagnostic or classification criteria, the disease has...
journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
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journal_title:Dermatologic therapy
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