Eccrine porocarcinoma.

Abstract:

:Eccrine porocarcinoma (EPC) is a rare cutaneous neoplasm that grows slowly over a long period of time but often experiences an accelerated growth phase. This malignant tumor may arise denovo or evolve from a pre-existing benign eccrine poroma. Histologic evaluation demonstrates anaplastic cells involving the epidermis and infiltrating the dermis. Metastasis to regional lymph nodes distally occurs in a significant number of cases. Treatment modalities have included standard excision, Mohs micrographic surgery (MMS), chemotherapy, and radiation therapy. Recently sentinel lymph node biopsy has begun to be investigated as a staging tool. The literature on EPC is reviewed with attention paid to which of the various therapeutic options offers a clear advantage over the others. MMS affords the greatest likelihood of clear margins and cure in absence of regional and distant metastases.

journal_name

Dermatol Ther

journal_title

Dermatologic therapy

authors

Brown CW Jr,Dy LC

doi

10.1111/j.1529-8019.2008.00243.x

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

433-8

issue

6

eissn

1396-0296

issn

1529-8019

pii

DTH243

journal_volume

21

pub_type

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