Abstract:
:Ultrapotent topical corticosteroids and circumcision are usually effective for male genital lichen sclerosus (MGLSc); however, refractory cases are often referred to our Male Genital Dermatology Unit. Treatment with autologous platelet-rich plasma (TPRP) has recently been advocated as a safe and effective treatment option, but there have been no prospective studies in men to date. The objective of this study is to assess the safety and efficacy of TPRP for MGLSc resistant to conventional therapy. A prospective, open-label, single-arm, therapeutic study was carried out in this study. Inclusion criteria: resistant to conventional therapy for at least 6 months. Procedure: infiltration of 0.1 mL/cm2 PRP every 8 weeks. Monthly data recording: visual appearance with photographs and external scoring by an expert using Investigator's Global Assessment Scale (IGA scale 0-5), symptoms (scale 0-5), quality of life (QoL; Dermatology Life Quality Index [DLQI]), and complications. No. of patients included was n = 5. No. of patients excluded during treatment was n = 1. Mean initial IGA: 3.6. Mean initial DLQI: 6. TPRP n = 34 (range: 2-9; average: 6.8 per patient). Mean IGA at 18 months: 3.25. Mean DLQI at 18 months: 1.25. All patients reported being completely asymptomatic at 10 months. No. of patients with complications is n = 1 (balanitis). TPRP seems to be safe and effective, regarding symptom control and improvement in QoL; however, visual changes were minimal.
journal_name
Dermatol Therjournal_title
Dermatologic therapyauthors
Navarrete J,Echarte L,Sujanov A,Guillones A,Vola M,Bunker CB,Agorio C,Touriño Cdoi
10.1111/dth.14032subject
Has Abstractpub_date
2020-11-01 00:00:00pages
e14032issue
6eissn
1396-0296issn
1529-8019journal_volume
33pub_type
杂志文章abstract::Vitiligo progression is attributed to immune system malfunctioning, thus immunomodulating compounds might be beneficial in stopping vitiligo progression which is a prerequisite for successful repigmentation. The goal of this study was to assess efficacy of acridone acetic acid, sodium salt (Na-AAA), an immunomodulatin...
journal_title:Dermatologic therapy
pub_type: 临床试验,杂志文章
doi:10.1111/dth.12121
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journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/j.1529-8019.2010.01307.x
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journal_title:Dermatologic therapy
pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章,随机对照试验
doi:10.1111/dth.12259
更新日期:2015-11-01 00:00:00
abstract::Malignant melanoma accounts for 80% of deaths due to skin cancer. Its incidence is globally increasing. However, melanoma mortality seems to be decreasing. The aim of this study was to analyze mortality rates due to melanoma in Andalusia between 1979 and 2018. Deaths due to melanoma and mid-year population in Andalusi...
journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.14715
更新日期:2020-12-26 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/j.1529-8019.2012.01515.x
更新日期:2012-11-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2008.00243.x
更新日期:2008-11-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.13476
更新日期:2020-07-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.13733
更新日期:2020-07-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12061
更新日期:2014-03-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 临床试验,杂志文章
doi:10.1111/dth.12334
更新日期:2016-05-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/j.1529-8019.2006.00095.x
更新日期:2006-11-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.12748
更新日期:2019-01-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12932
更新日期:2019-07-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2005.00030.x
更新日期:2005-07-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13510
更新日期:2020-07-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1529-8019.2005.05016.x
更新日期:2005-03-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/j.1396-0296.2004.04006.x
更新日期:2004-01-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
doi:10.1111/dth.12071
更新日期:2013-07-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 信件
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journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
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journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.13331
更新日期:2020-05-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12615
更新日期:2018-07-01 00:00:00
abstract::Palmoplantar pustulosis is a chronic inflammatory disease which characterized by a eruption of sterile pustules on the palms and soles. Apremilast is an oral phosphodiesterase-4 inhibitor which is approved for the treatment of chronic plaque psoriasis and psoriatic arthritis. However, no clinical trial has been perfor...
journal_title:Dermatologic therapy
pub_type: 信件
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更新日期:2020-03-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
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更新日期:2020-05-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
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更新日期:2019-09-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
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更新日期:2020-03-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章
doi:10.1111/dth.12595
更新日期:2018-05-01 00:00:00
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journal_title:Dermatologic therapy
pub_type: 杂志文章,评审
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更新日期:2011-11-01 00:00:00