BRCA1 Is a Novel Prognostic Indicator and Associates with Immune Cell Infiltration in Hepatocellular Carcinoma.

abstract：:Tumor cells express lower levels of manganese superoxide dismutase (MnSOD) than their normal counterparts. Enforced expression of MnSOD reverses the malignant phenotype of many transformed cells, suggesting that SOD2 is a tumor suppressor. The SOD2 gene contains a large CpG island spanning > 3.5 kb that starts near th...

journal_title：DNA and cell biology

authors： Huang Y,He T,Domann FE

更新日期：1999-08-01 00:00:00

abstract：:Sequence analysis of the 5' end of the thrombomodulin (TM) gene has identified a difference in two strains of laboratory mice, BALB/cBD (maintained at the Oak Ridge National Laboratory) and the strain used for the sequence listed in the GenBank data base. An intracisternal A-particle (IAP) provirus was present in the ...

journal_title：DNA and cell biology

authors： Ford VA,Kennel SJ

更新日期：1993-05-01 00:00:00

abstract：:Duchenne muscular dystrophy is the most common and severe form of progressive muscular dystrophy. Previous results showed an increased survival in double knockout mice (dko) when treated with adipose-derived CD146+ cells. In this study, we analyzed the effect of CD146+ cells compared to mesenchymal stem/stromal cells ...

journal_title：DNA and cell biology

authors： Gomes JP,Coatti GC,Valadares MC,Assoni AF,Pelatti MV,Secco M,Zatz M

更新日期：2018-09-01 00:00:00

abstract：:We have isolated and sequenced cDNA clones that encode human spermine synthase (EC 2.5.1.22). The total length of the sequenced cDNA was 1,612 nucleotides, containing an open reading frame encoding a polypeptide chain of 368 amino acids. All of the previously sequenced peptide fragments of human and bovine spermine sy...

journal_title：DNA and cell biology

authors： Korhonen VP,Halmekytö M,Kauppinen L,Myöhänen S,Wahlfors J,Keinänen T,Hyvönen T,Alhonen L,Eloranta T,Jänne J

更新日期：1995-10-01 00:00:00

abstract：:Homomeric and heteromeric interactions among cell-surface tyrosine kinase receptors belonging to the ErbB family lead to intracellular signaling cascades which are involved in cell activation, cytoskeletal interactions, and cellular transformation leading to neoplasia. Monoclonal antibodies which specifically bind to ...

journal_title：DNA and cell biology

authors： Peterson NC,Greene MI

更新日期：1998-12-01 00:00:00

abstract：:It is widely believed that cellular senescence is a tumor suppressor mechanism; however, it has not been understood why it is advantageous for organisms to retain mutant cells is a postmitotic state rather than simply eliminating them by apoptosis. It has recently been proposed that the primary role of cellular senesc...

journal_title：DNA and cell biology

authors： Lynch MD

更新日期：2006-02-01 00:00:00

abstract：:DNA methylation plays an essential role in carcinogenesis. Promoter hypermethylation can result in transcriptional silencing of specific genes, such as tumor suppressors. Thus far, few reports have investigated the effect of curcumin, an active component of the perennial herb Curcuma longa, on DNA methylation. In the ...

journal_title：DNA and cell biology

authors： Wu B,Yao X,Nie X,Xu R

更新日期：2013-06-01 00:00:00

abstract：:We examined the chromosomal basis for the synthesis of tissue (ovary, endometrium/placenta, and peri-implantation blastocyst) isoforms of cytochrome P450 aromatase in the pig. DNA fragments derived from three distinct porcine aromatase chromosomal genes were cloned and characterized. The porcine type III aromatase gen...

journal_title：DNA and cell biology

authors： Choi I,Troyer DL,Cornwell DL,Kirby-Dobbels KR,Collante WR,Simmen FA

更新日期：1997-06-01 00:00:00

abstract：:The recent explosion of scientific and technical knowledge in the field of molecular biology has allowed us to make important advances in our understanding of the molecular basis of many human diseases. This technology has now entered the clinical laboratory where identification of specific genetic sequences can aid i...

journal_title：DNA and cell biology

authors： Crisan D,Mattson JC

更新日期：1993-06-01 00:00:00

abstract：:The abnormal function of O(6)-methylguanine-DNA methyltransferase (MGMT) is reported to be associated with the occurrence of various tumors and malignant tumor progression. However, little evidence is available to describe its role in esophageal carcinogenesis. To address this issue, we constructed a stable MGMT-silen...

journal_title：DNA and cell biology

authors： Su Y,Liu R,Sheng J,Liu H,Wang Y,Pan E,Guo W,Pu Y,Zhang J,Liang G,Tang D,Yin L

更新日期：2012-05-01 00:00:00

abstract：:Palindromati, the massive host-edited synthetic palindromic contamination found in GenBank, is illustrated and exemplified. Millions of contaminated sequences with portions or tandems of such portions derived from the ZAP adaptor or related linkers are shown (1) by the 12-bp sequence reported elsewhere, exon Xb, 5' CC...

journal_title：DNA and cell biology

authors： Castro-Chavez F

更新日期：2012-02-01 00:00:00

abstract：:Polymerase chain reaction [PCR, reverse transcriptase-PCR (RT-PCR)] has been used to amplify the mRNA subspecies of the plasma membrane calcium pump isoform 1 (PMCA1) in total RNA extracted from hamster tissues. Two primers were synthesized that encompass the site at which a 154-bp exon is included totally (PMCA1a), p...

journal_title：DNA and cell biology

authors： Sarkar FH,Ball DE,Tsang W,Li YW,Kuo TH

更新日期：1993-06-01 00:00:00

abstract：:The globally distributed American cockroach (Periplaneta americana) is considered a pest, but it has been widely used in traditional Chinese medicine. In the past, the American cockroach's genome and transcriptomes were sequenced, but the differential expression transcripts between developmental stages were unavailabl...

journal_title：DNA and cell biology

authors： Zeng C,Li W,Liao Q,Yan T,Wang K,Hu Y,Shen Y,Price M,Fan Z,Zhang X,Yue B,Geng F,Chen L

更新日期：2019-10-01 00:00:00

abstract：:Zidovudine (AZT) is widely used in the treatment of human immunodeficiency virus (HIV) infection because of its ability to act as a false substrate for the viral reverse transcriptase. AZT in the clinical setting has also been shown to produce significant hematologic and other toxicity, even though prior reports in th...

journal_title：DNA and cell biology

authors： Nusbaum NJ,Joseph PE

更新日期：1996-05-01 00:00:00

abstract：:Most studies on the tissue distribution of actin isoform transcripts have been done in small mammals such as rat and mouse. We have begun a characterization of the actin gene family in a large mammal, the bovine. The alpha skeletal gene was isolated, and an isoform-specific probe to the 3' untranslated region of the t...

journal_title：DNA and cell biology

authors： Davey HW,Wildeman AG

更新日期：1995-06-01 00:00:00

abstract：:It is well known that the positively charged polyamines have a DNA-stabilizing function and that polyamine depletion alters chromatin function. We have previously shown that polyamine depletion causes an S phase prolongation, and others have shown that there is an accumulation of Okazaki-like fragments in polyamine-de...

journal_title：DNA and cell biology

authors： Johansson VM,Oredsson SM,Alm K

更新日期：2008-09-01 00:00:00

abstract：:Heterotrimeric G proteins, which are composed of Gα and Gβγ subunits, transduce signals sensed by the coupled surface receptors. Aberrant expressions of G proteins have been observed in many cancer types. This study aimed to determine the expression level of the stimulatory G protein alpha S subunit (Gαs, the main tra...

journal_title：DNA and cell biology

authors： Zhang B,Sun N,Mu X,Zhi L,Zhai L,Jiang Y,Fu Z,Yao Z

更新日期：2017-03-01 00:00:00

abstract：:dTMP kinase (E.C.2.7.4.9.) catalyzes the phosphorylation of dTMP to the corresponding diphosphate. This enzyme is essential for DNA synthesis in vivo and is an important intermediate enzyme in the pathway of many pyrimidine analog drugs. In this report, we describe the isolation of the human dTMP kinase gene by functi...

journal_title：DNA and cell biology

authors： Huang SH,Tang A,Drisco B,Zhang SQ,Seeger R,Li C,Jong A

更新日期：1994-05-01 00:00:00

abstract：:Endogenous phytohormones auxin (indole-3-acetic acid [IAA]), abscisic acid (ABA), gibberellin (GA3), and brassinosteroid (BR) play a role in responses to drought stress in higher plants. Tea plant is one of the major economic corps worldwide. The tender shoots of tea plants are the main source for tea production. The ...

journal_title：DNA and cell biology

authors： Li H,Teng RM,Liu JX,Yang RY,Yang YZ,Lin SJ,Han MH,Liu JY,Zhuang J

更新日期：2019-11-01 00:00:00

abstract：:Intestinal phospholipase A/lysophospholipase (IPAL) is an intestine-specific brush-border enzyme expressed during development and along the intestinal crypt-villus axis in a pattern similar to another well characterized brush-border enzyme, sucrase-isomaltase (SI). A tissue-specific DNase I hypersensitive site was ide...

journal_title：DNA and cell biology

authors： Taylor JK,Boll W,Levy T,Suh E,Siang S,Mantei N,Traber PG

更新日期：1997-12-01 00:00:00

abstract：:We have isolated and characterized a cDNA encoding a chicken beta homolog of c-erbA, or thyroid hormone receptor (TR). Chicken liver cDNA libraries were screened with a rat TR beta-1 cDNA probe, and several cDNA inserts were isolated and characterized. The sequence of one cDNA predicts a 369-amino-acid open reading fr...

journal_title：DNA and cell biology

authors： Showers MO,Darling DS,Kieffer GD,Chin WW

更新日期：1991-04-01 00:00:00

abstract：:Deer antlers are amazing natural appendages that grow faster than any other known mammalian bone. Antler growth occurs at the tip and is initially cartilage, which is later replaced by bone tissue. However, little is known regarding the precise role of cooperation between cell lineages and functional genes in regulati...

journal_title：DNA and cell biology

authors： Yao B,Zhang M,Liu M,Wang Q,Liu M,Zhao Y

更新日期：2018-01-01 00:00:00

abstract：:Culture of CHO.K1, a Chinese hamster ovary cell line, requires no particular care about the glucocorticoid level in media. Cell growth of CHO.K1 is little affected by dexamethasone at concentrations up to 3 microM. A clone of CHO.K1 stably transfected with an expression vector displayed a favored growth in dexamethaso...

journal_title：DNA and cell biology

authors： Chen GS,Lee CH,Lee YC,Chi CW,Liu YC

更新日期：1996-02-01 00:00:00

abstract：:Plastins (or fimbrins) are a family of actin-binding proteins that are conserved from yeast to humans. In mammals, three tissue-specific plastin isoforms have been identified. The L isoform (L-plastin) is normally expressed only in leukocytes but is also found in >90% of neoplastic nonleukocyte human cells. Because L-...

journal_title：DNA and cell biology

authors： Lin CS,Chang CH,Huynh T

更新日期：1997-01-01 00:00:00

abstract：:Exposure to microgravity is supposed to affect almost all biological systems, and we speculated that microgravity is potentially involved in autophagy regulation. A clinostat was used to simulate microgravity, and HEK293 cells that stably express GFP-LC3 were used for sensitive monitoring of autophagy induction. The c...

journal_title：DNA and cell biology

authors： Ryu HW,Choi SH,Namkoong S,Jang IS,Seo DH,Choi I,Kim HS,Park J

更新日期：2014-03-01 00:00:00

abstract：:Denaturing gradient gel electrophoresis (DGGE) was used to examine error rates and mutations induced by native (wt) and exonuclease-deficient (exo-) Deep Vent DNA polymerases during DNA amplification by polymerase chain reaction (PCR), in the presence or absence of the T4 bacteriophage gene 32 protein (gp32).gp32 was ...

journal_title：DNA and cell biology

authors： Huang H,Keohavong P

更新日期：1996-07-01 00:00:00

abstract：:Voltage-gated potassium channels play important functional roles in the development and maintenance of human lymphocyte functions. One such channel, known as the type n channel, has been well defined in human T cells and exhibits unique functional properties that distinguish it from other species of potassium channels...

journal_title：DNA and cell biology

authors： Cai YC,Osborne PB,North RA,Dooley DC,Douglass J

更新日期：1992-03-01 00:00:00

abstract：:Epidemiological evidence on the relationship between IL1A and/or IL1B polymorphisms and periodontal disease is inconsistent. We investigated associations between three IL1 single-nucleotide polymorphisms (SNPs) in genes encoding interleukin (IL) -1α (rs1800587) and IL-1β (rs1143634 and rs16944) and the risk of periodo...

journal_title：DNA and cell biology

authors： Tanaka K,Miyake Y,Hanioka T,Arakawa M

更新日期：2014-04-01 00:00:00

abstract：:Minimally modified low-density lipoprotein (MM-LDL) is regarded as a major risk factor for the development of atherosclerosis. In this report, we show that this lipoprotein complex can induce expression of an inflammatory protein, serum amyloid A (SAA), in monocyte/macrophage cells, a key cell type implicated in the p...

journal_title：DNA and cell biology

authors： Ray BK,Chatterjee S,Ray A

更新日期：1999-01-01 00:00:00

abstract：:In a systematic approach to identify interferon-gamma (IFN-gamma)-regulated host effector molecules, we found several members of the 65 kDa guanylate-binding proteins (GBPs) highly upregulated. During extensive characterization of these guanosine triphosphatases (GTPases), we identified discrepancies between the clone...

journal_title：DNA and cell biology

authors： Konermann C,Kresse A,Beuter-Gunia C,Würthner J,Degrandi D,Pfeffer K,Beer S

更新日期：2007-12-01 00:00:00