Molecular analysis of bovine actin gene and pseudogene sequences: expression of nonmuscle and striated muscle isoforms in adult tissues.

abstract：:Acetate and β-hydroxybutyrate (BHBA) are the predominant substrates for de novo fatty acid (FA) synthesis in mammary gland of dairy cow. To investigate the nutrigenomic role of acetate and BHBA in bovine mammary epithelial cells during milk fat production, RNA sequencing (RNA-seq) transcriptomic analysis was used to i...

journal_title：DNA and cell biology

authors： Song S,Jiang M,Zhou J,Zhao F,Hou X,Lin Y

更新日期：2020-03-01 00:00:00

abstract：:Polyhomeotic is a member of the Polycomb group of genes. The products of this group are chromatin-associated proteins that act together as multimeric complexes. These proteins are required for the maintenance of target gene repression in a permanent and heritable manner during development. In order to better understan...

journal_title：DNA and cell biology

authors： Netter S,Faucheux M,Théodore L

更新日期：2001-08-01 00:00:00

abstract：:A series of overlapping cDNAs coding for mouse prothrombin (coagulation factor II) have been isolated and the composite DNA sequence has been determined. The complete prothrombin cDNA is 1,987 bp in length [excluding the poly(A) tail] and codes for 18 bp of 5' untranslated sequence, an open reading frame coding for 61...

journal_title：DNA and cell biology

authors： Degen SJ,Schaefer LA,Jamison CS,Grant SG,Fitzgibbon JJ,Pai JA,Chapman VM,Elliott RW

更新日期：1990-09-01 00:00:00

abstract：:Deer antlers are amazing natural appendages that grow faster than any other known mammalian bone. Antler growth occurs at the tip and is initially cartilage, which is later replaced by bone tissue. However, little is known regarding the precise role of cooperation between cell lineages and functional genes in regulati...

journal_title：DNA and cell biology

authors： Yao B,Zhang M,Liu M,Wang Q,Liu M,Zhao Y

更新日期：2018-01-01 00:00:00

abstract：:Parkinson's disease (PD) is a serious neurodegenerative disorder that lacks effective therapeutic methods. In this research, expressions of PPARα, RXRα, and miR-21 were evaluated in PD patients and normal controls. To investigate the effects of miR-21, docosahexaenoic acid (DHA) and aspirin (ASA) on PD, as well as the...

journal_title：DNA and cell biology

authors： Fu Y,Zhen J,Lu Z

更新日期：2017-06-01 00:00:00

abstract：:Ginsenoside, a natural triterpenoid saponin, exhibits immunomodulatory and anticancer activities. In the present study, we demonstrated that ginsenoside Rg1 induced secretion of cytokines, including interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α), and IL-1β, and chemokines such as IL-8 and IP-10 in a dose-depe...

journal_title：DNA and cell biology

authors： Huang Y,Zou Y,Lin L,Zheng R

更新日期：2017-12-01 00:00:00

abstract：:The globally distributed American cockroach (Periplaneta americana) is considered a pest, but it has been widely used in traditional Chinese medicine. In the past, the American cockroach's genome and transcriptomes were sequenced, but the differential expression transcripts between developmental stages were unavailabl...

journal_title：DNA and cell biology

authors： Zeng C,Li W,Liao Q,Yan T,Wang K,Hu Y,Shen Y,Price M,Fan Z,Zhang X,Yue B,Geng F,Chen L

更新日期：2019-10-01 00:00:00

abstract：:Human T cells express HLA class II molecules upon activation. The factors that regulate the induction of expression of these molecules are for the most part unknown. Here we report preliminary results indicating that tumor necrosis factor-alpha (TNF-alpha) regulates the induction of cell-surface HLA-DR, DO, and DP mol...

journal_title：DNA and cell biology

authors： Kamoun M,Zerva L,Sloan S,Zmijewski C,Monos D,Trinchieri G

更新日期：1992-04-01 00:00:00

abstract：:Recently, we demonstrated that the DAN gene product contains a growth- and/or a tumor-suppressive activity in vitro. In the present work, using a yeast two-hybrid system, we searched for cellular proteins that can associate with the DAN gene product. A cDNA clone, termed DA41, was initially isolated from an adult rat ...

journal_title：DNA and cell biology

authors： Ozaki T,Hishiki T,Toyama Y,Yuasa S,Nakagawara A,Sakiyama S

更新日期：1997-08-01 00:00:00

abstract：:We have cloned and mapped the chromosomal location of three novel human genes encoding G protein-coupled receptors that we have named GPR6, GPR5, and GPR4. The entire coding region for each of these genes was contained on single exons. Gene GPR6 encoded a receptor that shared closest identity (71% in the transmembrane...

journal_title：DNA and cell biology

authors： Heiber M,Docherty JM,Shah G,Nguyen T,Cheng R,Heng HH,Marchese A,Tsui LC,Shi X,George SR

更新日期：1995-01-01 00:00:00

abstract：:The aim of this article is to review our current understanding of the role of cytokines, chemokines, T cells, Langerhans cells, and neutrophils (PMN) and their interactions in vivo in the host response to Pseudomonas aeruginosa ocular challenge. The cellular/cytokine network in vivo has begun to be unraveled, and the ...

journal_title：DNA and cell biology

authors： Hazlett LD

更新日期：2002-05-01 00:00:00

abstract：:The mdmx gene was shown to possess high homology to the mdm-2 gene and to encode a protein that can bind p53 and block p53 transactivation. Because Mdm-2 protein blocks the growth-suppressive activity of the p53 tumor-suppressor protein through similar activities, we examined the expression patterns of mdmx to determi...

journal_title：DNA and cell biology

authors： Jackson MW,Berberich SJ

更新日期：1999-09-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is a disease with multifactorial etiology characterized by irreversible loss of central visual acuity. The discovery of susceptive single-nucleotide polymorphisms (SNPs) has progressed our understanding of AMD. Complement factor H (CFH) gene Y402H polymorphism and high-temperatur...

journal_title：DNA and cell biology

authors： Soysal Y,Inan UÜ,Küsbeci T,Imirzalioğlu N

更新日期：2012-03-01 00:00:00

abstract：:A variety of human cancer cells are resistant to Fas ligand and anti-Fas antibody induced apoptosis. Previously, we reported that human gastric carcinoma cell lines were resistant to the anti-Fas antibody, CH-11, without interferon-gamma pretreatment in vitro. Cyclooxygenase (COX)-2 is known to be expressed in many hu...

journal_title：DNA and cell biology

authors： Honjo S,Osaki M,Ardyanto TD,Hiramatsu T,Maeta N,Ito H

更新日期：2005-03-01 00:00:00

abstract：:Cytochrome P450 15 beta is a female-specific gene product that catalyzes the hydroxylation of steroid sulfates at the 15 beta position. Isolation and analysis of the gene for rat P450 15 beta reveals nine coding exons and encompasses more than 35 kb of chromosomal DNA. The intron-exon junctions are at similar position...

journal_title：DNA and cell biology

authors： Zaphiropoulos PG,Westin S,Ström A,Mode A,Gustafsson JA

更新日期：1990-01-01 00:00:00

abstract：:Homomeric and heteromeric interactions among cell-surface tyrosine kinase receptors belonging to the ErbB family lead to intracellular signaling cascades which are involved in cell activation, cytoskeletal interactions, and cellular transformation leading to neoplasia. Monoclonal antibodies which specifically bind to ...

journal_title：DNA and cell biology

authors： Peterson NC,Greene MI

更新日期：1998-12-01 00:00:00

abstract：:Sterol regulatory element-binding proteins (SREBPs) are transcription factors governing transcription of genes related to cholesterol and fatty acid metabolism. To become active, SREBPs must undergo a proteolytic cleavage to allow an active NH(2)-terminal segment to translocate into the nucleus. SKI-1/S1P is the first...

journal_title：DNA and cell biology

authors： De Windt A,Rai M,Bernier L,Thelen K,Soini J,Lefebvre C,Chintawar S,Lavigne J,Saarinen L,Kytömäki L,Munzer JS,Lütjohann D,Pandolfo M,Davignon J,Seidah NG,Laaksonen R

更新日期：2007-11-01 00:00:00

abstract：:This research aims to investigate the immune-associated gene signature from databases to improve the prognostic value in hepatocellular carcinoma (HCC) by multidimensional methods using various bioinformatic methods. Fifty-one immune-associated genes were mined out, which were associated with clinical characters throu...

journal_title：DNA and cell biology

authors： Chen W,Tang D,Ou M,Dai Y

更新日期：2020-04-01 00:00:00

abstract：:In this study, we mined out hepatocellular carcinoma (HCC) driver genes from MEDLINE literatures by bioinformatics methods of pathway crosstalk and protein interaction network. Furthermore, the relationship between driver genes and their clinicopathological characteristics, as well as classification effectiveness was ...

journal_title：DNA and cell biology

authors： Chen W,Jiang J,Wang PP,Gong L,Chen J,Du W,Bi K,Diao H

更新日期：2019-10-01 00:00:00

abstract：:Duchenne muscular dystrophy is the most common and severe form of progressive muscular dystrophy. Previous results showed an increased survival in double knockout mice (dko) when treated with adipose-derived CD146+ cells. In this study, we analyzed the effect of CD146+ cells compared to mesenchymal stem/stromal cells ...

journal_title：DNA and cell biology

authors： Gomes JP,Coatti GC,Valadares MC,Assoni AF,Pelatti MV,Secco M,Zatz M

更新日期：2018-09-01 00:00:00

abstract：:Adipose-derived stem cells/adipose-derived progenitor cells (ADPCs) are multipotent stem cells that can differentiate in vitro into many cell types. However, the vast majority of experimental materials were obtained from human, mouse, rabbit, and other mammals but rarely from poultry. In this study, ADPCs were isolate...

journal_title：DNA and cell biology

authors： Gong X,Hou L,Bai C,Jin D,He X,Guan W,Ma Y

更新日期：2011-07-01 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) is an important oncogenic transcription factor residing in the cytoplasm in the resting cells. Upon stimulation, STAT3 is activated and translocated to the nucleus to regulate target genes. Although the canonical transcriptional function of STAT3 has been inte...

journal_title：DNA and cell biology

authors： Yan B,Xie S,Liu Z,Luo Y,Zhou J,Li D,Liu M

更新日期：2015-04-01 00:00:00

abstract：:DNA condensed agents can improve the transfection efficiency of the cationic liposome delivery system. However, various condensed agents have distinct transfection efficiency and cellular cytotoxicity. The object of this study was to screen the optimal agents with the high transfection efficiency and low cytotoxicity ...

journal_title：DNA and cell biology

authors： Wang J,Ye X,Ni H,Zhang J,Ju S,Ding W

更新日期：2019-10-01 00:00:00

abstract：:Microsomal transfer protein (MTP), a lipid transfer protein localized in the endoplasmic reticulum of hepatocytes and enterocytes, plays an important role in the development of nonalcoholic fatty liver disease (NAFLD). Many existing studies have demonstrated that a common polymorphism (-493G>T, rs1800591 G>T) in the M...

journal_title：DNA and cell biology

authors： Zheng W,Wang L,Su X,Hu XF

更新日期：2014-06-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) play important roles in the development of human cancers. This is the first case-control study of the association between specific polymorphisms in lncRNA genes and the risk of lung cancer, as well as the gene-environment interaction between the polymorphisms and cooking oil fume exposure...

journal_title：DNA and cell biology

authors： Gao M,Li H,Lv X,Zhou B,Yin Z

更新日期：2018-08-01 00:00:00

abstract：:Based on the concept of sequence conservation around the active sites of serine proteinases, polymerase chain reaction applied to mRNA amplification allowed us to obtain a 260-bp probe which was used to screen a mouse pituitary cDNA library. The primers used derived from the cDNA sequence of active sites Ser* and Asn*...

journal_title：DNA and cell biology

authors： Seidah NG,Gaspar L,Mion P,Marcinkiewicz M,Mbikay M,Chrétien M

更新日期：1990-07-01 00:00:00

abstract：:Peroxisomes are membrane-bound organelles that are best known for their roles in lipid metabolism. Mounting evidence indicates that they are also important nodes for antiviral signaling. While research over the past few decades has revealed effective viral strategies to block antiviral signalling pathways from the pla...

journal_title：DNA and cell biology

authors： Wong CP,Xu Z,Power C,Hobman TC

更新日期：2018-05-01 00:00:00

abstract：:Hepatocyte nuclear factor-1alpha (HNF-1alpha) is a homeodomain-containing transcription factor regulating the expression of liver and pancreas-specific genes. Mutations in the HNF-1alpha-encoding gene TCF1 cause maturity-onset diabetes of the young, type 3 (MODY3). These mutations may affect nuclear import or reduce t...

journal_title：DNA and cell biology

authors： Bjørkhaug L,Bratland A,Njølstad PR,Molven A

更新日期：2005-11-01 00:00:00

abstract：:We have analyzed the interleukin-1 beta (IL-1 beta) promoter region near the cap site. Specific DNA sequences required for lipopolysaccharide (LPS) induction within this region were identified using transfection of reporter plasmids that contained portions of the proximal IL-1 beta 5'-flanking sequence. An LPS-respons...

journal_title：DNA and cell biology

authors： Godambe SA,Chaplin DD,Takova T,Bellone CJ

更新日期：1994-06-01 00:00:00

abstract：:Matrix metalloproteinase-7 (MMP-7) is a small secreted proteolytic enzyme with broad substrate specificity. Its expression is associated with tumor invasion, metastasis, and survival for a number of cancers. However, data from published studies with individually low statistical power are conflicting. Here, we performe...

journal_title：DNA and cell biology

authors： Yuan-Yuan M,Li-Feng Z,Li-Jie Z

更新日期：2012-05-01 00:00:00