cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases.

abstract：:The gene for the bovine oxytocin receptor has been sequenced using a combination of clones derived from a bovine endometrial cDNA library from estrus and a bovine genomic DNA library, with confirmation of structure using reverse transcription PCR programmed by term myometrial RNA. The receptor belongs to the seven tra...

journal_title：DNA and cell biology

authors： Bathgate R,Rust W,Balvers M,Hartung S,Morley S,Ivell R

更新日期：1995-12-01 00:00:00

abstract：:Porifera (sponges) constitute the lowest metazoan phylum. Experiments examined whether sponges can recognize self/nonself molecules. Cells from the marine sponge Suberites domuncula were incubated with membranes from either S. domuncula or another marine sponge, Geodia cydonium, as well as with recombinant alpha-integ...

journal_title：DNA and cell biology

authors： Müller WE,Perovic S,Wilkesman J,Kruse M,Müller IM,Batel R

更新日期：1999-12-01 00:00:00

abstract：:Quantitative determination of T-cell receptor (TCR) V beta expression is necessary to define the changes in TCR-V beta subfamily expression that occur during T-cell maturation and selection and to detect alterations of the TCR-V beta repertoire that may be associated with human diseases. Here we describe and validate ...

journal_title：DNA and cell biology

authors： Duchmann R,Strober W,James SP

更新日期：1993-04-01 00:00:00

abstract：:Ulcerative colitis (UC) is a long-time inflammatory condition arising from aberrant immune activation in the colon and the rectum. Interleukin (IL)-35 plays critical roles in autoimmune disorders. In this study, we explored the pathways of IL-35 in affecting UC. First, peripheral blood mononuclear cells (PBMCs) from U...

journal_title：DNA and cell biology

authors： Wang S,Qin C

更新日期：2017-05-01 00:00:00

abstract：:Temporal coordination of meiosis with spermatid morphogenesis is crucial for successful generation of mature sperm cells. We identified a recessive male sterile Drosophila melanogaster mutant, mitoshell, in which events of spermatid morphogenesis are initiated too early, before meiotic onset. Premature mitochondrial a...

journal_title：DNA and cell biology

authors： Bergner LM,Hickman FE,Wood KH,Wakeman CM,Stone HH,Campbell TJ,Lightcap SB,Favors SM,Aldridge AC,Hales KG

更新日期：2010-09-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) may serve as potential molecular diagnostic markers to improve the capacity of earlier and more accurate diagnosis of dilated cardiomyopathy (DCM). We integrated five independent transcriptomic datasets (n = 504) from Gene Expression Omnibus for systematic identification of lncRNA-based d...

journal_title：DNA and cell biology

authors： Zhang H,Chen X,Zhang D,Liu L,Song J,Xu Y,Tian J

更新日期：2020-11-03 00:00:00

abstract：:Single-nucleotide polymorphisms (SNPs) in pre-miRNAs may alter microRNA (miRNA) expression levels or processing and contribute to susceptibility to a wide range of diseases. We investigated the correlation between four SNPs (rs11614913, rs3746444, rs2910164, and rs229283) in pre-miRNAs and the risk of asthma in 220 as...

journal_title：DNA and cell biology

authors： Su XW,Yang Y,Lv ML,Li LJ,Dong W,Miao-Liao,Gao LB,Luo HB,Yun-Liu,Cong RJ,Liang WB,Li YB

更新日期：2011-11-01 00:00:00

abstract：:We demonstrated earlier that post-exposure prophylaxis with 3'-azido-3'-deoxythymidine (AZT, zidovudine) or with AZT + interferon-alpha (IFN-alpha) prevented viremia and disease in BALB/c mice inoculated with Rauscher murine leukemia virus (RLV). After the 20-day treatment course, most animals were resistant to rechal...

journal_title：DNA and cell biology

authors： Ruprecht RM,Bronson R

更新日期：1994-01-01 00:00:00

abstract：:In this study we report main properties of Harbinger DNA transposons identified in protists, plants, insects, worms, and vertebrates. This is the first superfamily of eukaryotic DNA transposons where all autonomous transposons, even those that are hosted by species from different kingdoms, encode two proteins: a super...

journal_title：DNA and cell biology

authors： Kapitonov VV,Jurka J

更新日期：2004-05-01 00:00:00

abstract：:Gene expression is modulated by epigenetic factors that come in varying forms, such as DNA methylation, histone modifications, microRNAs, and long noncoding RNAs. Recent studies reveal that these epigenetic marks are important regulatory factors in brain function. In particular, DNA methylation dynamics are found to b...

journal_title：DNA and cell biology

authors： Irier HA,Jin P

更新日期：2012-10-01 00:00:00

abstract：:Uterine corpus endometrial carcinoma (UCEC) is a common malignancy in the female reproductive system, associated with high morbidity and mortality. Despite the high prevalence of UCEC, molecular understanding of uterine endothelium tumorigenesis remains poorly understood. In this study, we reported that transcription ...

journal_title：DNA and cell biology

authors： Li Q,Lei Y,Du W

更新日期：2018-05-01 00:00:00

abstract：:Previously we cloned a polyspecific transporter from rat (rOCT1) that is expressed in renal proximal tubules and hepatocytes and mediates electrogenic uptake of organic cations with different molecular structures. Recently a homologous transporter from rat kidney (rOCT2) was cloned but not characterized in detail. We ...

journal_title：DNA and cell biology

authors： Gorboulev V,Ulzheimer JC,Akhoundova A,Ulzheimer-Teuber I,Karbach U,Quester S,Baumann C,Lang F,Busch AE,Koepsell H

更新日期：1997-07-01 00:00:00

abstract：:Genes involved in the production of nitric oxide (NO) have been suggested as genetic factors for migraine. It has been studied whether polymorphisms in the genes encoding for different types of NO synthase (NOS) could be involved in the liability to migraine; however, most studies yield negative results. The pentanucl...

journal_title：DNA and cell biology

authors： Jia S,Ni J,Chen S,Jiang Y,Dong W,Gao Y

更新日期：2011-02-01 00:00:00

abstract：:The Wilms' tumor gene 1 (WT1) protein is a transcriptional regulator that is highly expressed in immature hematopoietic progenitor cells and in the majority of patients with acute and chronic myeloid leukemia. However, it is still unclear how WT1 exerts its function(s) in hematopoietic cells. The aim of this work was ...

journal_title：DNA and cell biology

authors： Svensson E,Vidovic K,Olofsson T,Vallon-Christersson J,Borg A,Gullberg U

更新日期：2007-08-01 00:00:00

abstract：:DNA methylation plays an essential role in carcinogenesis. Promoter hypermethylation can result in transcriptional silencing of specific genes, such as tumor suppressors. Thus far, few reports have investigated the effect of curcumin, an active component of the perennial herb Curcuma longa, on DNA methylation. In the ...

journal_title：DNA and cell biology

authors： Wu B,Yao X,Nie X,Xu R

更新日期：2013-06-01 00:00:00

abstract：:Increasing evidence suggested that long noncoding RNAs (lncRNAs) variants may be involved in the progression of various cancers. However, the association of the lncRNAs polymorphisms with the risk for esophagogastric junction adenocarcinoma (EGJA) is still unknown. In this case-control study, we selected two cancer-re...

journal_title：DNA and cell biology

authors： Cao R,Chen Y,Wang J,Chen M,Chen S,Tang W

更新日期：2020-05-01 00:00:00

abstract：:My 45 years of studying the molecular biology of adeno-associated virus are recounted. Additional activities as a mentor, department chair, and medical school administrator are described, as are my activities in the public sphere, which involved national issues related to science policy and medical education. ...

journal_title：DNA and cell biology

authors： Berns KI

更新日期：2013-07-01 00:00:00

abstract：:The serotonin (5-hydroxytryptamine) transporter (5HTt) gene has been reported to be associated with suicidal behavior. In this study, we have investigated the 5' promoter region (i.e., 5HTt gene-linked polymorphic region [5-HTTLPR]) and a 17-base pair variable number of tandem repeats polymorphism in the 5HTt gene for...

journal_title：DNA and cell biology

authors： Akar T,Sayin A,Bakkaloğlu Z,Cabuk DK,Küçükyildirim S,Demirel B,Candansayar S,Ozsoy ED,Mergen H

更新日期：2010-08-01 00:00:00

abstract：:The nuclear factor of κB (NFκB) family has been well known for its significant role in regulating the expression of numerous genes that control many biological processes. However, it is unclear whether NFκB could regulate milk synthesis. In this study, we identified NFκB1 as a critical regulator for milk synthesis in ...

journal_title：DNA and cell biology

authors： Huang X,Zang Y,Zhang M,Yuan X,Li M,Gao X

更新日期：2017-04-01 00:00:00

abstract：:Rat cytokine-induced neutrophil chemoattractant (CINC) is an 8-kD polypeptide originally purified from media conditioned by interleukin-1 beta (IL-1 beta)-stimulated 52E, an epithelioid clone derived from the normal rat kidney (NRK) cell line. Using a fibroblastic clone of NRK cells, 49F, we found that lipopolysacchar...

journal_title：DNA and cell biology

authors： Dolecki GJ,Delarco JE

更新日期：1994-09-01 00:00:00

abstract：:Minimally modified low-density lipoprotein (MM-LDL) is regarded as a major risk factor for the development of atherosclerosis. In this report, we show that this lipoprotein complex can induce expression of an inflammatory protein, serum amyloid A (SAA), in monocyte/macrophage cells, a key cell type implicated in the p...

journal_title：DNA and cell biology

authors： Ray BK,Chatterjee S,Ray A

更新日期：1999-01-01 00:00:00

abstract：:We have determined the expression pattern of all 11 human replication-dependent histone H3 genes in three fetal human tissues (bladder, liver, and lung) and in eight human cell lines by RNase protection assay. In the fetal human tissues, all 11 genes were expressed to a varied extent. However, the relative contributio...

journal_title：DNA and cell biology

authors： Koessler H,Doenecke D,Albig W

更新日期：2003-04-01 00:00:00

abstract：:Sestrin2 is involved in a different cellular response to stress conditions. However, the function of Sestrin2 in the cardiovascular system remains unknown. In the present study, we tested whether Sestrin2 has a beneficial effect on macrophage cell apoptosis induced by oxidized low-density lipoprotein (oxLDL). We found...

journal_title：DNA and cell biology

authors： Hu HJ,Shi ZY,Lin XL,Chen SM,Wang QY,Tang SY

更新日期：2015-04-01 00:00:00

abstract：:A series of overlapping cDNAs coding for mouse prothrombin (coagulation factor II) have been isolated and the composite DNA sequence has been determined. The complete prothrombin cDNA is 1,987 bp in length [excluding the poly(A) tail] and codes for 18 bp of 5' untranslated sequence, an open reading frame coding for 61...

journal_title：DNA and cell biology

authors： Degen SJ,Schaefer LA,Jamison CS,Grant SG,Fitzgibbon JJ,Pai JA,Chapman VM,Elliott RW

更新日期：1990-09-01 00:00:00

abstract：:Butyrate is a naturally occurring product of colonic microbial fermentation of dietary carbohydrates that escape hydrolysis in the small intestine. Butyrate plays a significant role in the maintenance of colonic tissue homeostasis by regulating the expression of genes associated with the processes of proliferation, di...

journal_title：DNA and cell biology

authors： Daly K,Shirazi-Beechey SP

更新日期：2006-01-01 00:00:00

abstract：:It is widely believed that cellular senescence is a tumor suppressor mechanism; however, it has not been understood why it is advantageous for organisms to retain mutant cells is a postmitotic state rather than simply eliminating them by apoptosis. It has recently been proposed that the primary role of cellular senesc...

journal_title：DNA and cell biology

authors： Lynch MD

更新日期：2006-02-01 00:00:00

abstract：:MicroRNAs (miRNAs) are an important class of small, noncoding, regulatory RNAs found to be involved in regulating a wide variety of important cellular processes by the sequence-specific inhibition of gene expression. Viruses have evolved a number of mechanisms to take advantage of the regulatory potential of this high...

journal_title：DNA and cell biology

authors： Dykxhoorn DM

更新日期：2007-04-01 00:00:00

abstract：:Epulopiscium sp. type B, a member of the Firmicutes, is a large (up to 300 microm), cigar-shaped bacterial symbiont of surgeonfish that propagates itself by forming multiple intracellular offspring. This unusual form of reproduction is an apparent modification of a developmental program used by some Firmicutes to prod...

journal_title：DNA and cell biology

authors： Ward RJ,Clements KD,Choat JH,Angert ER

更新日期：2009-02-01 00:00:00

abstract：:Myocardial ischemic disease affects the prognosis in perioperative patients. Diabetes can aggravate myocardial injury. The purpose of this research is to investigate the effect of ferroptosis in the process of diabetes mellitus (DM) myocardial ischemia/reperfusion (I/R) injury (IRI). Endoplasmic reticulum stress (ERS)...

journal_title：DNA and cell biology

authors： Li W,Li W,Leng Y,Xiong Y,Xia Z

更新日期：2020-02-01 00:00:00

abstract：:The incidence of premature ovarian failure (POF), a condition causing amenorrhea and hypergonadotropic hypoestrogenism in women before the age of 40, has been increasing in recent years. As an irreversible pathological change, improved treatment strategies for this disease are urgently needed. In this study, a type of...

journal_title：DNA and cell biology

authors： Liu T,Qin W,Huang Y,Zhao Y,Wang J

更新日期：2013-12-01 00:00:00