Harbinger transposons and an ancient HARBI1 gene derived from a transposase.

abstract：:Microsomal transfer protein (MTP), a lipid transfer protein localized in the endoplasmic reticulum of hepatocytes and enterocytes, plays an important role in the development of nonalcoholic fatty liver disease (NAFLD). Many existing studies have demonstrated that a common polymorphism (-493G>T, rs1800591 G>T) in the M...

journal_title：DNA and cell biology

authors： Zheng W,Wang L,Su X,Hu XF

更新日期：2014-06-01 00:00:00

abstract：:The potential association of variant surface glycoprotein (VSG) gene expression with clonal expression of virulence in African trypanosomes was addressed. Two populations of clonally related trypanosomes, which differ dramatically in virulence for the infected host, but display the same apparent VSG surface coat pheno...

journal_title：DNA and cell biology

authors： Inverso JA,Uphoff TS,Johnson SC,Paulnock DM,Mansfield JM

更新日期：2010-05-01 00:00:00

abstract：:The Egr-1 (zfp-6) gene encodes a zinc-finger-containing nuclear protein that is rapidly and transiently induced in quiescent cells treated with mitogens. We have constructed baculovirus vectors that synthesize mouse Egr-1 protein initiating at two putative ATG start sites. The ATG site producing the larger protein (Mr...

journal_title：DNA and cell biology

authors： Ragona G,Edwards SA,Mercola DA,Adamson ED,Calogero A

更新日期：1991-01-01 00:00:00

abstract：:Eaf2 encodes a tumor suppressor that plays multiple functions in transcriptional activation, apoptosis, and embryonic development. In this study, we utilized GFP-EAF2 fusion protein to describe the dynamic subcellular movement of Eaf2. GFP-EAF2 is preferentially localized to the nucleus, and in the presence of ELL, it...

journal_title：DNA and cell biology

authors： Zhuang F,Yen P,Zhao J,Nguyen M,Jiang M,Liu YH

更新日期：2008-12-01 00:00:00

abstract：:We have cloned and sequenced the cDNA corresponding to the rat preproepidermal growth factor (ppEGF) mRNA. The cDNA contained 4,801 nucleotides, similar to that reported for the mouse (4,749 nucleotides) and the human mRNAs (4,871 nucleotides). The predicted protein sequence would contain 1,133 amino acids, smaller th...

journal_title：DNA and cell biology

authors： Saggi SJ,Safirstein R,Price PM

更新日期：1992-07-01 00:00:00

abstract：:In the current study, we evaluated the potential effect of a novel sphingosine kinase 1 (SphK1) activator, K6PC-5, on oxygen-glucose deprivation (OGD)/reoxygenation-induced damages to myocardial cells. We demonstrated that K6PC-5 increased intracellular sphingosine-1-phosphate (S1P) content and remarkably inhibited OG...

journal_title：DNA and cell biology

authors： Shao JJ,Peng Y,Wang LM,Wang JK,Chen X

更新日期：2015-11-01 00:00:00

abstract：:G0S8 is a member of a set of putative G0/G1 switch regulatory genes (G0S genes) selected by screening cDNA libraries prepared from blood mononuclear cells cultured for 2 hr with lectin and cycloheximide. Comparison of a full-length cDNA sequence with the corresponding genomic sequence reveals an open reading frame of ...

journal_title：DNA and cell biology

authors： Siderovski DP,Heximer SP,Forsdyke DR

更新日期：1994-02-01 00:00:00

abstract：:The nuclear factor of κB (NFκB) family has been well known for its significant role in regulating the expression of numerous genes that control many biological processes. However, it is unclear whether NFκB could regulate milk synthesis. In this study, we identified NFκB1 as a critical regulator for milk synthesis in ...

journal_title：DNA and cell biology

authors： Huang X,Zang Y,Zhang M,Yuan X,Li M,Gao X

更新日期：2017-04-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) is known for its ability to infect immune cells, including T-cells and macrophages. The 96-amino acid Vpr, a virion-associated protein, is essential for viral replication in monocytes/macrophages and increases viral replication in primary and established T-cell lines. The Vp...

journal_title：DNA and cell biology

authors： Muthumani K,Montaner LJ,Ayyavoo V,Weiner DB

更新日期：2000-03-01 00:00:00

abstract：:Osteosarcoma (OS) is a bone malignancy with high incidence. The underlying molecular mechanisms that are associated with the development of OS need further investigation. In this study, we showed that SLC34A2, a member of the solute carrier gene family, was significantly downregulated in OS patients and cell lines. Ov...

journal_title：DNA and cell biology

authors： Liu X,Zhou X,Xu H,He Z,Shi X,Wu S

更新日期：2017-09-01 00:00:00

abstract：:RUNX2 is a member of the RUNX family of transcription factors, also containing the RUNX1 and RUNX3 proteins. These factors control the expression of genes essential for proper development in many cell lineages. RUNX2 plays a crucial role in the proliferation and differentiation of osteoblasts, required for bone format...

journal_title：DNA and cell biology

authors： Wysokinski D,Pawlowska E,Blasiak J

更新日期：2015-05-01 00:00:00

abstract：:We have shown previously that rat hepatoma FTO-2B cells express two mRNAs, called F (fetal) and L (liver), from distinct promoters of the same gene coding for 6-phosphofructo-2-kinase (PFK-2). This enzyme catalyzes the synthesis of fructose 2,6-bisphosphate, an allosteric stimulator of glycolysis. We have now found th...

journal_title：DNA and cell biology

authors： Dupriez VJ,Rousseau GG

更新日期：1997-09-01 00:00:00

abstract：:High-mobility group protein A1 (HMGA1), an architectural transcription factor, was found to regulate multiple gene expression in mammals. Recent studies firmly indicate an association between HMGA1 and type 2 diabetes. However, the presence and function of HMGA1 in diabetic vasculopathy has not been substantiated. in ...

journal_title：DNA and cell biology

authors： Zhang Q,Chen L,Zhao Z,Wu Y,Zhong J,Wen G,Cao R,Zu X,Liu J

更新日期：2018-04-01 00:00:00

abstract：:We previously showed that the human AKNA gene encodes an AT-hook transcription factor that regulates the expression of costimulatory cell surface molecules on lymphocytes. However, AKNA cDNA probes hybridize with multiple transcripts, suggesting either the existence of other homologous genes or a complex regulation op...

journal_title：DNA and cell biology

authors： Sims-Mourtada JC,Bruce S,McKeller MR,Rangel R,Guzman-Rojas L,Cain K,Lopez C,Zimonjic DB,Popescu NC,Gordon J,Wilkinson MF,Martinez-Valdez H

更新日期：2005-05-01 00:00:00

abstract：:Sterol carrier protein2 (SCP2) is a 13.2-kD protein that is thought to be involved in the intracellular transport of cholesterol. Using synthetic oligonucleotides based on the protein sequence of SCP2, a clone (SP43) was isolated from a rat liver cDNA library. The DNA sequence revealed that the cDNA could encode a pol...

journal_title：DNA and cell biology

authors： Billheimer JT,Strehl LL,Davis GL,Strauss JF 3rd,Davis LG

更新日期：1990-04-01 00:00:00

abstract：:Rat cytokine-induced neutrophil chemoattractant (CINC) is an 8-kD polypeptide originally purified from media conditioned by interleukin-1 beta (IL-1 beta)-stimulated 52E, an epithelioid clone derived from the normal rat kidney (NRK) cell line. Using a fibroblastic clone of NRK cells, 49F, we found that lipopolysacchar...

journal_title：DNA and cell biology

authors： Dolecki GJ,Delarco JE

更新日期：1994-09-01 00:00:00

abstract：:Among environmental pollutants, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin) is one of the most potent tumor promoters and teratogens known. The molecular mechanisms responsible for the biological activity of TCDD, however, remain largely unknown. In this report, we show that the first observable effects of TCDD...

journal_title：DNA and cell biology

authors： Puga A,Nebert DW,Carrier F

更新日期：1992-05-01 00:00:00

abstract：:Plants, being sessile organisms, have evolved several dynamic mechanisms of gene regulation. Epigenetic modification especially cytosine methylation and demethylation actively regulates the expression of genes. To understand the role of cytosine methylation during isoflavonoid biosynthesis and accumulation, we perform...

journal_title：DNA and cell biology

authors： Gupta OP,Dahuja A,Sachdev A,Jain PK,Kumari S,T V,Praveen S

更新日期：2019-06-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) refers to breast cancer without significant expression of estrogen receptor (ER), progesterone receptor (PR), or human epidermal growth factor receptor 2. We sought to identify the hub genes and find the potential progression mechanism of TNBC as well as immunotherapeutic targets. ...

journal_title：DNA and cell biology

authors： Wang F,Cao X,Yin L,Wang Q,He Z

更新日期：2020-10-01 00:00:00

abstract：:Chromosomal gain on 1q23-24 is a cytogenetic finding found in approximately 30% of bladder tumors. Currently, no defined or candidate tumor-associated genes from this region have been identified. The objective of this study was to identify and quantitate the expression of putative cancer genes located at this chromoso...

journal_title：DNA and cell biology

authors： Huang WC,Taylor S,Nguyen TB,Tomaszewski JE,Libertino JA,Malkowicz SB,McGarvey TW

更新日期：2002-10-01 00:00:00

abstract：:This study aimed to construct a breast cancer model that could continuously express the genes of luciferase and green fluorescent protein. The genes luciferase, EGFP, and Neo were obtained by fusion polymerase chain reaction (PCR) and inserted into pAAV-MCS. The pAAV-Luciferase-EGFP-Neo vector was transfected into MDA...

journal_title：DNA and cell biology

authors： Huang C,Lan W,Wang F,Zhang C,Liu X,Chen Q

更新日期：2017-01-01 00:00:00

abstract：:A cDNA library derived from poly(A)+RNA of bull seminal vesicle tissue was screened with synthetic DNA probes specific for seminalplasmin (SAP), the major basic protein of bull semen. From a number of positive clones, pBSV12, containing a 577-bp insert, was identified and sequenced. The derived amino acid sequence com...

journal_title：DNA and cell biology

authors： Wagner S,Freudenstein J,Scheit KH

更新日期：1990-07-01 00:00:00

abstract：:Sterol regulatory element-binding proteins (SREBPs) are transcription factors governing transcription of genes related to cholesterol and fatty acid metabolism. To become active, SREBPs must undergo a proteolytic cleavage to allow an active NH(2)-terminal segment to translocate into the nucleus. SKI-1/S1P is the first...

journal_title：DNA and cell biology

authors： De Windt A,Rai M,Bernier L,Thelen K,Soini J,Lefebvre C,Chintawar S,Lavigne J,Saarinen L,Kytömäki L,Munzer JS,Lütjohann D,Pandolfo M,Davignon J,Seidah NG,Laaksonen R

更新日期：2007-11-01 00:00:00

abstract：:Transgenic mice expressing interleukin-12 (IL-12) under the glial fibrillary acidic protein (GFAP) promoter were evaluated for their sensitivity to herpes simplex virus type 1 (HSV-1) infection of the cornea. There was a modest but significant decrease in the infiltration of mononuclear cells in the cornea of the GFAP...

journal_title：DNA and cell biology

authors： Carr DJ,Ash J,Al-Khatib K,Campbell IL

更新日期：2002-05-01 00:00:00

abstract：:Endothelin-converting enzyme-1 (ECE1) plays a key role in the development of a subset of neural crest lineages such as cardiogenesis. Genetic variants of ECE1 C338A (rs213045) and T839G (rs213046) have been shown to alter ECE1 expression. This observation led us to hypothesize that two polymorphisms might influence th...

journal_title：DNA and cell biology

authors： Wang Y,Liu Y,Peng W,Wang M,Sun J,Zhang Z,Mo X

更新日期：2012-08-01 00:00:00

abstract：:Human T cells express HLA class II molecules upon activation. The factors that regulate the induction of expression of these molecules are for the most part unknown. Here we report preliminary results indicating that tumor necrosis factor-alpha (TNF-alpha) regulates the induction of cell-surface HLA-DR, DO, and DP mol...

journal_title：DNA and cell biology

authors： Kamoun M,Zerva L,Sloan S,Zmijewski C,Monos D,Trinchieri G

更新日期：1992-04-01 00:00:00

abstract：:An increasing amount of evidence suggests that interleukin-18 (IL-18) plays a pivotal role in the pathophysiology of schizophrenia. However, association between single nucleotide polymorphism of IL-18 and the risk of schizophrenia has not been clarified. This study examined whether two promoter polymorphisms -137 G/C ...

journal_title：DNA and cell biology

authors： Liu J,Liu J,Zhou Y,Li S,Li Y,Song X,Wang J,Wang L,Ying B

更新日期：2011-11-01 00:00:00

abstract：:The upstream transcription control region of the rat alpha-fetoprotein (AFP) gene was analyzed using transient expression of CAT genes in HepG2 cells which express the gene; H4C3 cells which repress the AFP gene but express the albumin gene; and four nonexpressing cell lines. Deletion analysis based on the DNA sequenc...

journal_title：DNA and cell biology

authors： Wen P,Groupp ER,Buzard G,Crawford N,Locker J

更新日期：1991-09-01 00:00:00

abstract：:MicroRNAs (miRNA) are a class of small noncoding RNA molecules that have been implicated in a wide variety of cellular functions through post-transcriptional regulations on target genes. Common genetic variants (single-nucleotide polymorphisms, SNPs) in pre-miRNA genes may alter their expression and/or maturation effe...

journal_title：DNA and cell biology

authors： Mittal RD,Gangwar R,George GP,Mittal T,Kapoor R

更新日期：2011-06-01 00:00:00

abstract：:The micronucleus (MN) assay in exfoliated buccal cells is a useful and minimally invasive method for monitoring genetic damage in humans exposed to occupational and environmental agents. The MN test is used as an indicator of genotoxic exposition, since it is associated with chromosome aberrations. An increased mutati...

journal_title：DNA and cell biology

authors： Celik A,Diler SB,Eke D

更新日期：2010-06-01 00:00:00