Abstract:
:Osteosarcoma (OS) is a bone malignancy with high incidence. The underlying molecular mechanisms that are associated with the development of OS need further investigation. In this study, we showed that SLC34A2, a member of the solute carrier gene family, was significantly downregulated in OS patients and cell lines. Overexpression of SLC34A2 inhibited the proliferation, migration, and invasion of OS cells. Mechanistically, we found that SLC34A2 interacted with PTEN, and inactivated the PI3K/AKT signaling pathway. Collectively, our results demonstrated that SLC34A2 plays important roles in regulating the cancer cell growth of OS. The downregulation of SLC34A2 in OS patients suggested that it might be a promising target in the diagnosis and therapy of OS.
journal_name
DNA Cell Bioljournal_title
DNA and cell biologyauthors
Liu X,Zhou X,Xu H,He Z,Shi X,Wu Sdoi
10.1089/dna.2017.3750subject
Has Abstractpub_date
2017-09-01 00:00:00pages
775-780issue
9eissn
1044-5498issn
1557-7430pii
10.1089/dna.2017.3750journal_volume
36pub_type
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