Dioxin induces expression of c-fos and c-jun proto-oncogenes and a large increase in transcription factor AP-1.

abstract：:The gene encoding the mouse cellular retinoic acid-binding protein (CRABP) has been isolated from a mouse genomic library and its structure has been determined. This gene spans approximately 10.5 kb and consists of four exons encoding 24, 59, 38, and 16 amino acid residues, respectively. This gene structure is very si...

journal_title：DNA and cell biology

authors： Wei LN,Tsao JL,Chu YS,Jeannotte L,Nguyen-Huu MC

更新日期：1990-09-01 00:00:00

abstract：:Interleukin-6 (IL-6) signaling may play a causal role in the development of coronary heart disease. However, the relationship between IL-6 genotypes and plasma levels of IL-6 appears to be complex. To help clarify the inconsistent findings, we conducted a meta-analysis of the published genetic association studies of t...

journal_title：DNA and cell biology

authors： Huang M,Wang L,Ma H,Wang J,Xiang M

更新日期：2013-11-01 00:00:00

abstract：:Apelin, an endogenous ligand for apelin receptor (APJ), is reported to be involved in cardiomyocyte hypertrophy. In this study, we explored the mechanism of cardiomyocyte hypertrophy induced by apelin-13/APJ system. Left ventricular hypertrophy (LVH) rat model was established by constricting the abdominal aorta. Weste...

journal_title：DNA and cell biology

authors： Wu D,Xie F,Xiao L,Feng F,Huang S,He L,Liu M,Zhou Q,Li L,Chen L

更新日期：2017-08-01 00:00:00

abstract：:Tumor cells express lower levels of manganese superoxide dismutase (MnSOD) than their normal counterparts. Enforced expression of MnSOD reverses the malignant phenotype of many transformed cells, suggesting that SOD2 is a tumor suppressor. The SOD2 gene contains a large CpG island spanning > 3.5 kb that starts near th...

journal_title：DNA and cell biology

authors： Huang Y,He T,Domann FE

更新日期：1999-08-01 00:00:00

abstract：:In this study, we isolated two cDNA molecules encoding putative glutamate receptor subunits, fGluR1 alpha and fGluR1 beta, from an Oreochromis sp. brain cDNA library by hybridizing with the glutamate receptor cDNA, fGluR2 beta, of the same fish. The deduced amino acid sequence of the fGluR1 alpha consists of 908 resid...

journal_title：DNA and cell biology

authors： Wu YM,Kung SS,Chen J,Chow WY

更新日期：1996-09-01 00:00:00

abstract：:Dengue virus serotype 3 (DENV-3) was associated with severe dengue epidemics in Thailand during 1973-1999. We studied Thai DENV-3 viruses isolated from hospitalized children in Bangkok with differing disease severity during that period. Viruses were sequenced at their 5' and 3' untranslated regions (UTRs), which are r...

journal_title：DNA and cell biology

authors： Pankhong P,Weiner DB,Ramanathan MP,Nisalak A,Kalayanarooj S,Nimmannitya S,Attatippaholkun W

更新日期：2009-10-01 00:00:00

abstract：:Increasing evidence has announced the emerging roles of long noncoding RNAs (lncRNAs) in modulating bone homeostasis due to their potential regulating effects on bone-related cells' proliferation, migration, differentiation and apoptosis. Thus, lncRNAs have been considered as a promising gene tool to facilitate the bo...

journal_title：DNA and cell biology

authors： Song W,Xie J,Li J,Bao C,Xiao Y

更新日期：2020-06-01 00:00:00

abstract：:The prototypic member of the transforming growth factor beta family is TGFbeta1, which is known to be important in extracellular matrix production, cell proliferation, and cell differentiation. Specifically in the pituitary lactotroph, TGFbeta1 inhibits prolactin (PRL) peptide secretion, PRL mRNA levels, and PRL gene ...

journal_title：DNA and cell biology

authors： Farrow KN,Gutierrez-Hartmann A

更新日期：1999-11-01 00:00:00

abstract：:The overexpression of prosurvival members of the Bcl-2 family is commonly associated with the enhanced malignancy of hematological tumors. There has been great interest in a novel set of agents that are able to mimic the function of the BH3 domain by binding to the groove of Bcl-2-like proteins and initiating the cell...

journal_title：DNA and cell biology

authors： Turner BC,Eves T,Refaeli Y

更新日期：2008-03-01 00:00:00

abstract：:There is strong evidence for the presence of a functional renin-angiotensin system in human adipose tissue. The aim of our study was to investigate the association of polymorphic variants of angiotensin-converting enzyme gene (ACE I/D) and angiotensin II type I receptor gene (AGTR1 A1166C) with extreme obesity and obe...

journal_title：DNA and cell biology

authors： Pacholczyk M,Ferenc T,Kowalski J,Adamczyk P,Chojnowski J,Ponikowska I

更新日期：2013-08-01 00:00:00

abstract：:The PC12 pheochromocytoma cell line has been a favorite model system for cell and neurobiologists, but has proven relatively refractory to standard DNA transfection methods. We have found that the cationic lipid "lipofectin" provides a simple, gentle, and nontoxic procedure that vastly improves transfection efficienci...

journal_title：DNA and cell biology

authors： Muller SR,Sullivan PD,Clegg DO,Feinstein SC

更新日期：1990-04-01 00:00:00

abstract：:Leber congenital amaurosis (LCA) causes severe visual impairment and blindness very early in life. Mutant alleles of several genes acting in different pathways, of which all have critical roles for normal retinal function, were involved in LCA development. The purpose of this study was to use genome-wide genotyping to...

journal_title：DNA and cell biology

authors： Yücel-Yılmaz D,Tarlan B,Kıratlı H,Ozgül RK

更新日期：2014-12-01 00:00:00

abstract：:We examined the chromosomal basis for the synthesis of tissue (ovary, endometrium/placenta, and peri-implantation blastocyst) isoforms of cytochrome P450 aromatase in the pig. DNA fragments derived from three distinct porcine aromatase chromosomal genes were cloned and characterized. The porcine type III aromatase gen...

journal_title：DNA and cell biology

authors： Choi I,Troyer DL,Cornwell DL,Kirby-Dobbels KR,Collante WR,Simmen FA

更新日期：1997-06-01 00:00:00

abstract：:Six identical cDNA clones corresponding to an RNA of 1685 nucleotides that is enriched in mouse sperm compared with testis were isolated from a mouse testis cDNA library. The sequence of these clones corresponds to the 16S mitochondrial RNA plus an inverted repeat of 120 bp covalently joined to the 5' end of the RNA. ...

journal_title：DNA and cell biology

authors： Villegas J,Zárraga AM,Muller I,Montecinos L,Werner E,Brito M,Meneses AM,Burzio LO

更新日期：2000-09-01 00:00:00

abstract：:Human T cells express HLA class II molecules upon activation. The factors that regulate the induction of expression of these molecules are for the most part unknown. Here we report preliminary results indicating that tumor necrosis factor-alpha (TNF-alpha) regulates the induction of cell-surface HLA-DR, DO, and DP mol...

journal_title：DNA and cell biology

authors： Kamoun M,Zerva L,Sloan S,Zmijewski C,Monos D,Trinchieri G

更新日期：1992-04-01 00:00:00

abstract：:We have determined the expression pattern of all 11 human replication-dependent histone H3 genes in three fetal human tissues (bladder, liver, and lung) and in eight human cell lines by RNase protection assay. In the fetal human tissues, all 11 genes were expressed to a varied extent. However, the relative contributio...

journal_title：DNA and cell biology

authors： Koessler H,Doenecke D,Albig W

更新日期：2003-04-01 00:00:00

abstract：:Design and synthesis of new small molecules binding to double-stranded RNA necessitate complete understanding of the molecular aspects of the binding of many existing molecules. Toward this goal, in this work we evaluated the biophysical aspects of the interaction of a DNA intercalator (proflavine) and a minor groove ...

journal_title：DNA and cell biology

authors： Sinha R,Hossain M,Kumar GS

更新日期：2009-04-01 00:00:00

abstract：:High-mobility group protein A1 (HMGA1), an architectural transcription factor, was found to regulate multiple gene expression in mammals. Recent studies firmly indicate an association between HMGA1 and type 2 diabetes. However, the presence and function of HMGA1 in diabetic vasculopathy has not been substantiated. in ...

journal_title：DNA and cell biology

authors： Zhang Q,Chen L,Zhao Z,Wu Y,Zhong J,Wen G,Cao R,Zu X,Liu J

更新日期：2018-04-01 00:00:00

abstract：:The abnormal function of O(6)-methylguanine-DNA methyltransferase (MGMT) is reported to be associated with the occurrence of various tumors and malignant tumor progression. However, little evidence is available to describe its role in esophageal carcinogenesis. To address this issue, we constructed a stable MGMT-silen...

journal_title：DNA and cell biology

authors： Su Y,Liu R,Sheng J,Liu H,Wang Y,Pan E,Guo W,Pu Y,Zhang J,Liang G,Tang D,Yin L

更新日期：2012-05-01 00:00:00

abstract：:DNA condensed agents can improve the transfection efficiency of the cationic liposome delivery system. However, various condensed agents have distinct transfection efficiency and cellular cytotoxicity. The object of this study was to screen the optimal agents with the high transfection efficiency and low cytotoxicity ...

journal_title：DNA and cell biology

authors： Wang J,Ye X,Ni H,Zhang J,Ju S,Ding W

更新日期：2019-10-01 00:00:00

abstract：:Fibroblast growth factor 21 (FGF-21) is a novel regulator for metabolic syndrome (MetS), diabetes, and obesity. However, no study has been performed on the association of these diseases with FGF-21 gene polymorphism. The aim of the study was to investigate the association of 3' untranslated region (UTR) single-nucleot...

journal_title：DNA and cell biology

authors： Zhang M,Zeng L,Wang YJ,An ZM,Ying BW

更新日期：2012-04-01 00:00:00

abstract：:Microsomal transfer protein (MTP), a lipid transfer protein localized in the endoplasmic reticulum of hepatocytes and enterocytes, plays an important role in the development of nonalcoholic fatty liver disease (NAFLD). Many existing studies have demonstrated that a common polymorphism (-493G>T, rs1800591 G>T) in the M...

journal_title：DNA and cell biology

authors： Zheng W,Wang L,Su X,Hu XF

更新日期：2014-06-01 00:00:00

abstract：:ERGIC2 (formerly known as PTX1) is a gene identified by subtractive hybridization on the basis that it is expressed in normal human prostate, but not in prostate carcinoma. It is unrelated to the gene encoding pituitary homeobox protein (Ptx1 or Pitx1), which regulates pituitary hormone gene expression. Based on seque...

journal_title：DNA and cell biology

authors： Kwok SC,Kumar S,Dai G

更新日期：2014-02-01 00:00:00

abstract：:To study the elements involved in the pituitary specific transcriptional regulation of the tilapia prolactin I gene (tiPRL I), we have cloned and entirely sequenced a 3.4-kb genomic fragment immediately upstream from the first exon. In footprinting experiments, three tilapia sequences are protected from DNase I digest...

journal_title：DNA and cell biology

authors： Poncelet AC,Levavi-Sivan B,Muller M,Yaron Z,Martial JA,Belayew A

更新日期：1996-08-01 00:00:00

abstract：:It is widely believed that cellular senescence is a tumor suppressor mechanism; however, it has not been understood why it is advantageous for organisms to retain mutant cells is a postmitotic state rather than simply eliminating them by apoptosis. It has recently been proposed that the primary role of cellular senesc...

journal_title：DNA and cell biology

authors： Lynch MD

更新日期：2006-02-01 00:00:00

abstract：:We have cloned a putative yeast homolog of the gene encoding the human Tat-binding protein, TBP-1. The gene termed TBPY encodes a 45,243-dalton protein displaying a heptad repeat of hydrophobic amino acids reminiscent of a leucine zipper. Secondary structure predictions suggest the possibility of formation of an amphi...

journal_title：DNA and cell biology

authors： Goyer C,Lee HS,Malo D,Sonenberg N

更新日期：1992-10-01 00:00:00

abstract：:The sex steroid hormone progesterone modulates the developmental and lactogenic activity of prolactin in the mammary gland. Regulation of the level of prolactin receptor (PRLR) provides one possible mechanism by which this may occur, prompting this investigation of the molecular mechanisms involved in progestin regula...

journal_title：DNA and cell biology

authors： Ormandy CJ,Graham J,Kelly PA,Clarke CL,Sutherland RL

更新日期：1992-12-01 00:00:00

abstract：:Sepsis is an inflammatory-related disease, and severe sepsis would induce multiorgan dysfunction, which is the most common cause of death of patients in noncoronary intensive care units. Progression of novel therapeutic strategies has proven to be of little impact on the mortality of severe sepsis, and unfortunately, ...

journal_title：DNA and cell biology

authors： Wang Y,Yin X,Yang F

更新日期：2018-02-01 00:00:00

abstract：:The human OZF gene encodes a protein consisting essentially of zinc finger motifs of the Krüppel type. Evolutionary studies revealed amplification of the bovine OZF gene in cattle. Domestic cattle includes two major subspecies: taurine (Bos primigenius taurus) and zebu (B. p. indicus). Amplified sequences were found i...

journal_title：DNA and cell biology

authors： Le Chalony C,Apiou F,Pibouin L,Dutrillaux B,Goubin G

更新日期：1996-01-01 00:00:00

abstract：:Mitochondrial aldehyde dehydrogenase-2 (ALDH2) is the principal enzyme involved in alcohol metabolism in humans. Emerging evidence has shown that the common rs671 G>A (Glu504Lys) polymorphism in the ALDH2 gene might play a critical role in increasing the susceptibility to coronary heart disease (CHD), including myocar...

journal_title：DNA and cell biology

authors： Wang Q,Zhou S,Wang L,Lei M,Wang Y,Miao C,Jin Y

更新日期：2013-07-01 00:00:00