Abstract:
:We have cloned a putative yeast homolog of the gene encoding the human Tat-binding protein, TBP-1. The gene termed TBPY encodes a 45,243-dalton protein displaying a heptad repeat of hydrophobic amino acids reminiscent of a leucine zipper. Secondary structure predictions suggest the possibility of formation of an amphipathic helix that could further be organized into a coiled-coil. Additionally, the protein product of TBPY shows amino acid signatures characteristic of a large family of RNA and DNA helicases. We propose that the hydrophobic region of yTBP-1 participates in self-dimerization or heterodimerization.
journal_name
DNA Cell Bioljournal_title
DNA and cell biologyauthors
Goyer C,Lee HS,Malo D,Sonenberg Ndoi
10.1089/dna.1992.11.579keywords:
subject
Has Abstractpub_date
1992-10-01 00:00:00pages
579-85issue
8eissn
1044-5498issn
1557-7430journal_volume
11pub_type
杂志文章abstract::The murine 18A2/mts1 and its human homolog h-mts1 (S100A4), encoding a Ca2+-binding protein belonging to the S-100 family, are associated with high invasive and metastatic potentials of murine tumors, human tumor cell lines in vitro, and human tumors growing as xenografts. The nm23 is a putative metastasis-suppressor ...
journal_title:DNA and cell biology
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journal_title:DNA and cell biology
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journal_title:DNA and cell biology
pub_type: 杂志文章
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journal_title:DNA and cell biology
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journal_title:DNA and cell biology
pub_type: 杂志文章
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journal_title:DNA and cell biology
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journal_title:DNA and cell biology
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journal_title:DNA and cell biology
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journal_title:DNA and cell biology
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