Characterization of genetic variation in the Forkhead box class O3 gene (FOXO3) in sheep.

abstract：:Mitochondrial FAD-linked glycerol-3-phosphate dehydrogenase (mtGPDH) is one of the two enzymes of the glycerol phosphate shuttle. This shuttle transfers reducing equivalents from the cytoplasm to the mitochondria in a unidirectional, exothermic manner. Here, the isolation and characterization of the rat nuclear gene (...

journal_title：DNA and cell biology

authors： Gong DW,Bi S,Weintraub BD,Reitman M

更新日期：1998-03-01 00:00:00

abstract：:Nitric oxide synthase (NOS) is the enzyme responsible for the conversion of L-arginine to L-citrulline and nitric oxide. Dimerization of the enzyme is an absolute requirement for catalytic activity. Each NOS monomer contains an N-terminal heme-binding domain and a C-terminal reductase domain. It is unclear how the red...

journal_title：DNA and cell biology

authors： Hallmark OG,Phung YT,Black SM

更新日期：1999-05-01 00:00:00

abstract：:High-mobility group protein A1 (HMGA1), an architectural transcription factor, was found to regulate multiple gene expression in mammals. Recent studies firmly indicate an association between HMGA1 and type 2 diabetes. However, the presence and function of HMGA1 in diabetic vasculopathy has not been substantiated. in ...

journal_title：DNA and cell biology

authors： Zhang Q,Chen L,Zhao Z,Wu Y,Zhong J,Wen G,Cao R,Zu X,Liu J

更新日期：2018-04-01 00:00:00

abstract：:In a systematic approach to identify interferon-gamma (IFN-gamma)-regulated host effector molecules, we found several members of the 65 kDa guanylate-binding proteins (GBPs) highly upregulated. During extensive characterization of these guanosine triphosphatases (GTPases), we identified discrepancies between the clone...

journal_title：DNA and cell biology

authors： Konermann C,Kresse A,Beuter-Gunia C,Würthner J,Degrandi D,Pfeffer K,Beer S

更新日期：2007-12-01 00:00:00

abstract：:A yeast two-hybrid system was used to identify mutants of Max that exhibit an increased affinity for Myc. Truncated forms of the Max helix-loop-helix/leucine zipper motif (HLH/Zip) were first expressed in a two- hybrid system in which the bait protein was the HLH/Zip motif of Myc. Deletion of amino acids both amino-te...

journal_title：DNA and cell biology

authors： Wang H,Van Den Bergh F,Spencer E,Wilcox K,Herman T

更新日期：1997-11-01 00:00:00

abstract：PURPOSE:This case-control study was conducted in order to evaluate the potential role of polymorphic genes encoding enzymes involved in estrogen biosynthesis (CYP19A1) and metabolism (GSTM1, GSTT1, and GSTP1), and their action in modulating individual susceptibility to breast cancer. METHODS:Genomic DNA was extracted ...

journal_title：DNA and cell biology

authors： Ramalhinho AC,Fonseca-Moutinho JA,Breitenfeld Granadeiro LA

更新日期：2012-06-01 00:00:00

abstract：:In our previous study, a kind of novel hybrid immunoglobulin (Ig)-binding proteins (IBPs) was obtained with the characteristic structure of alternately arranged Finegoldia magna (formerly Peptostreptococcus magnus) protein L (P. magnus protein L, PpL) B3 domain (B3) and Staphylococcal protein A (SpA) D domain (D). In ...

journal_title：DNA and cell biology

authors： Jiang SH,Wang JF,Xu R,Liu YJ,Wang XN,Cao J,Zhao P,Shen YJ,Yang T,Yang H,Jia JA,Chen QL,Pan W

更新日期：2008-08-01 00:00:00

abstract：:By using the methodology of both wet and dry biology (i.e., RT-PCR and cycle sequencing, and biocomputational technology, respectively) and the data obtained through the Genome Projects, we have cloned Xenopus laevis SOD2 (MnSOD) cDNA and determined its nucleotide sequence. These data and the deduced protein primary s...

journal_title：DNA and cell biology

authors： Purrello M,Di Pietro C,Ragusa M,Pulvirenti A,Giugno R,Di Pietro V,Emmanuele G,Travali S,Scalia M,Shasha D,Ferro A

更新日期：2005-02-01 00:00:00

abstract：:Protein-RNA complexation is essential in cell biological functions. Transfer RNAs are bound to aminoacyl-tRNA synthetases for the translation of the genetic code during protein synthesis, while ribonucleoproteins bind RNA in posttranscriptional regulation of gene expression. A recent report showed the interacton of hu...

journal_title：DNA and cell biology

authors： Malonga H,Neault JF,Tajmir-Riahi HA

更新日期：2006-07-01 00:00:00

abstract：:Palindromati, the massive host-edited synthetic palindromic contamination found in GenBank, is illustrated and exemplified. Millions of contaminated sequences with portions or tandems of such portions derived from the ZAP adaptor or related linkers are shown (1) by the 12-bp sequence reported elsewhere, exon Xb, 5' CC...

journal_title：DNA and cell biology

authors： Castro-Chavez F

更新日期：2012-02-01 00:00:00

abstract：:Genomic instability and epigenetic alterations are distinct hallmarks shared by cancer and aging. Sirtuins (SIRTs) are class III histone deacetylases that regulate gene expression in response to cellular metabolic status. SIRTs can modulate chromatin function through direct deacetylation of histones and by promoting a...

journal_title：DNA and cell biology

authors： Wu X,Cao N,Fenech M,Wang X

更新日期：2016-10-01 00:00:00

abstract：:A variety of human cancer cells are resistant to Fas ligand and anti-Fas antibody induced apoptosis. Previously, we reported that human gastric carcinoma cell lines were resistant to the anti-Fas antibody, CH-11, without interferon-gamma pretreatment in vitro. Cyclooxygenase (COX)-2 is known to be expressed in many hu...

journal_title：DNA and cell biology

authors： Honjo S,Osaki M,Ardyanto TD,Hiramatsu T,Maeta N,Ito H

更新日期：2005-03-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) production is regulated by growth factors and inflammatory cytokines, and VEGF plays a role in migraine. We examined for the first time whether three functional polymorphisms in the promoter region of VEGF gene (C(-2578)A, G(-1154)A, and G(-634)C) and VEGF haplotypes are assoc...

journal_title：DNA and cell biology

authors： Gonçalves FM,Martins-Oliveira A,Speciali JG,Izidoro-Toledo TC,Luizon MR,Dach F,Tanus-Santos JE

更新日期：2010-07-01 00:00:00

abstract：:Sterol regulatory element-binding proteins (SREBPs) are transcription factors governing transcription of genes related to cholesterol and fatty acid metabolism. To become active, SREBPs must undergo a proteolytic cleavage to allow an active NH(2)-terminal segment to translocate into the nucleus. SKI-1/S1P is the first...

journal_title：DNA and cell biology

authors： De Windt A,Rai M,Bernier L,Thelen K,Soini J,Lefebvre C,Chintawar S,Lavigne J,Saarinen L,Kytömäki L,Munzer JS,Lütjohann D,Pandolfo M,Davignon J,Seidah NG,Laaksonen R

更新日期：2007-11-01 00:00:00

abstract：:The expression of growth factors, proteolytic enzymes, fibrogenic factors, and cytokines is altered in the Helicobacter pylori-infected gastric mucosa. Therefore, we aimed to evaluate the association of functional promoter variants of transforming growth factor (TGF)-B1 and matrix metalloproteinase (MMP)-7 genes with ...

journal_title：DNA and cell biology

authors： Achyut BR,Ghoshal UC,Moorchung N,Mittal B

更新日期：2009-06-01 00:00:00

abstract：:Host cell-derived danger-associated molecular patterns (DAMPs), such as the hemoglobin (Hb) can interact with the innate immune system either directly or through binding to pathogen-associated molecular patterns (PAMPs). Hemolysis occurs under various pathological conditions, leading to hemoglobinemia. In the extracel...

journal_title：DNA and cell biology

authors： Lee SK,Ding JL

更新日期：2013-02-01 00:00:00

abstract：:Thioredoxin peroxidase (TPx) is an antioxidant protein that limits the activity of reactive oxygen species (ROS). We cloned the cDNA encoding the mouse homolog of TPx from an E14.5 brain cDNA library and analyzed its distribution and function in murine tissues. Comparison of the amino acid sequence of mouse TPx with t...

journal_title：DNA and cell biology

authors： Ichimiya S,Davis JG,O'Rourke DM,Katsumata M,Greene MI

更新日期：1997-03-01 00:00:00

abstract：:A constituent of green tea, (-)-epigallocatechin-3-gallate (EGCG) has been known to possess antiproliferative properties. In this study, we investigated the anticancer effects of EGCG in human papillomavirus (HPV)-16 associated cervical cancer cell line, CaSki cells. The growth inhibitory mechanism(s) and regulation o...

journal_title：DNA and cell biology

authors： Ahn WS,Huh SW,Bae SM,Lee IP,Lee JM,Namkoong SE,Kim CK,Sin JI

更新日期：2003-03-01 00:00:00

abstract：:DNA methylation plays an essential role in carcinogenesis. Promoter hypermethylation can result in transcriptional silencing of specific genes, such as tumor suppressors. Thus far, few reports have investigated the effect of curcumin, an active component of the perennial herb Curcuma longa, on DNA methylation. In the ...

journal_title：DNA and cell biology

authors： Wu B,Yao X,Nie X,Xu R

更新日期：2013-06-01 00:00:00

abstract：:Denaturing gradient gel electrophoresis (DGGE) was used to examine error rates and mutations induced by native (wt) and exonuclease-deficient (exo-) Deep Vent DNA polymerases during DNA amplification by polymerase chain reaction (PCR), in the presence or absence of the T4 bacteriophage gene 32 protein (gp32).gp32 was ...

journal_title：DNA and cell biology

authors： Huang H,Keohavong P

更新日期：1996-07-01 00:00:00

abstract：:The human immunodeficiency virus type I (HIV-1) accessory protein Vpr has been associated with the induction of programmed cell death (apoptosis) and cell-cycle arrest. Studies have shown the apoptotic effect of Vpr on primary and established cell lines and on diverse tissues including the central nervous system (CNS)...

journal_title：DNA and cell biology

authors： Cheng X,Mukhtar M,Acheampong EA,Srinivasan A,Rafi M,Pomerantz RJ,Parveen Z

更新日期：2007-02-01 00:00:00

abstract：:Endocytosis of the five rat somatostatin receptor subtypes (SSTR1-5) was investigated in transfected HEK cells by biochemical ligand binding assays and confocal microscopic analysis. Phenylarsine oxide-sensitive internalization of SSTR1-3 is dependent on SST-14 or SST-28, whereas only the octacosapeptide triggers this...

journal_title：DNA and cell biology

authors： Roth A,Kreienkamp HJ,Nehring RB,Roosterman D,Meyerhof W,Richter D

更新日期：1997-01-01 00:00:00

abstract：:DNA condensed agents can improve the transfection efficiency of the cationic liposome delivery system. However, various condensed agents have distinct transfection efficiency and cellular cytotoxicity. The object of this study was to screen the optimal agents with the high transfection efficiency and low cytotoxicity ...

journal_title：DNA and cell biology

authors： Wang J,Ye X,Ni H,Zhang J,Ju S,Ding W

更新日期：2019-10-01 00:00:00

abstract：:Ulcerative colitis (UC) is a long-time inflammatory condition arising from aberrant immune activation in the colon and the rectum. Interleukin (IL)-35 plays critical roles in autoimmune disorders. In this study, we explored the pathways of IL-35 in affecting UC. First, peripheral blood mononuclear cells (PBMCs) from U...

journal_title：DNA and cell biology

authors： Wang S,Qin C

更新日期：2017-05-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic and debilitating autoimmune disorder of the central nervous system in which the autoimmune T cells destroy myelin, thus causing lesion, damage, and neuronal dysfunction. Experimental autoimmune encephalomyelitis (EAE) is an animal model of MS that is particularly useful for testing...

journal_title：DNA and cell biology

authors： Pahan S,Pahan K

更新日期：2019-07-01 00:00:00

abstract：:Ginsenoside, a natural triterpenoid saponin, exhibits immunomodulatory and anticancer activities. In the present study, we demonstrated that ginsenoside Rg1 induced secretion of cytokines, including interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α), and IL-1β, and chemokines such as IL-8 and IP-10 in a dose-depe...

journal_title：DNA and cell biology

authors： Huang Y,Zou Y,Lin L,Zheng R

更新日期：2017-12-01 00:00:00

abstract：:MicroRNAs (miRNA) are a class of small noncoding RNA molecules that have been implicated in a wide variety of cellular functions through post-transcriptional regulations on target genes. Common genetic variants (single-nucleotide polymorphisms, SNPs) in pre-miRNA genes may alter their expression and/or maturation effe...

journal_title：DNA and cell biology

authors： Mittal RD,Gangwar R,George GP,Mittal T,Kapoor R

更新日期：2011-06-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a life-threatening disease that is often associated with chronic infection by hepatitis B and C viruses. Genetic polymorphisms have been reported to alter the risk for HCC development. Genetic studies based on the haplotype have an increased power for detecting disease associations co...

journal_title：DNA and cell biology

authors： Kiran M,Chawla YK,Jain M,Kaur J

更新日期：2009-11-01 00:00:00

abstract：:Mitochondrial ribosomal proteins are important for mitochondrial-encoded protein synthesis and mitochondrial function. In addition to their roles in mitoribosome assembly, several mitochondrial ribosome proteins are also implicated in cellular processes like cell cycle regulation, apoptosis, and mitochondrial homeosta...

journal_title：DNA and cell biology

authors： Li HB,Wang RX,Jiang HB,Zhang ED,Tan JQ,Xu HZ,Zhou RR,Xia XB

更新日期：2016-11-01 00:00:00

abstract：:The nuclear factor of κB (NFκB) family has been well known for its significant role in regulating the expression of numerous genes that control many biological processes. However, it is unclear whether NFκB could regulate milk synthesis. In this study, we identified NFκB1 as a critical regulator for milk synthesis in ...

journal_title：DNA and cell biology

authors： Huang X,Zang Y,Zhang M,Yuan X,Li M,Gao X

更新日期：2017-04-01 00:00:00