Use of a two-hybrid system to identify mutations in Max that confer increased affinity for Myc.

abstract：:We have further characterized the most distal of the three alpha-fetoprotein (AFP) enhancers required for expression of the AFP gene in fetal hepatocytes and yolk sac endodermal cells. Almost total rat AFP enhancer 3 (E3) activity is driven by a 160-bp fragment at -6 kb containing three target regions for nuclear prot...

journal_title：DNA and cell biology

authors： Thomassin H,Bois-Joyeux B,Delille R,Ikonomova R,Danan JL

更新日期：1996-12-01 00:00:00

abstract：:Effective and efficient efferocytosis of dead cells and associated cellular debris are critical to tissue homeostasis and healing of injured tissues. This important task was previously thought to be restricted to professional phagocytes (PPs). However, accumulating evidence has revealed another type of phagocyte, the ...

journal_title：DNA and cell biology

authors： Sihombing MAEM,Safitri M,Zhou T,Wang L,McGinty S,Zhang HJ,Yin Y,Peng Q,Qiu J,Wang G

更新日期：2021-01-13 00:00:00

abstract：:Tumor cells express lower levels of manganese superoxide dismutase (MnSOD) than their normal counterparts. Enforced expression of MnSOD reverses the malignant phenotype of many transformed cells, suggesting that SOD2 is a tumor suppressor. The SOD2 gene contains a large CpG island spanning > 3.5 kb that starts near th...

journal_title：DNA and cell biology

authors： Huang Y,He T,Domann FE

更新日期：1999-08-01 00:00:00

abstract：:Thioredoxin peroxidase (TPx) is an antioxidant protein that limits the activity of reactive oxygen species (ROS). We cloned the cDNA encoding the mouse homolog of TPx from an E14.5 brain cDNA library and analyzed its distribution and function in murine tissues. Comparison of the amino acid sequence of mouse TPx with t...

journal_title：DNA and cell biology

authors： Ichimiya S,Davis JG,O'Rourke DM,Katsumata M,Greene MI

更新日期：1997-03-01 00:00:00

abstract：:We describe a new vector system that allows efficient expression of heterologous proteins in transformed mouse L fibroblasts. This is due to its persistence at high copy numbers, achieved by a 370-bp amplification promoting element (muNTS1) derived from the nontranscribed spacer of murine rDNA. Copy number determinati...

journal_title：DNA and cell biology

authors： Hemann C,Gärtner E,Weidle UH,Grummt F

更新日期：1994-04-01 00:00:00

abstract：:Hearing loss in Ménière's disease (MD) is associated with loss of spiral ganglion neurons and hair cells. In a guinea pig model of endolymphatic hydrops, nitric oxide synthases (NOS) and oxidative stress mediate loss of spiral ganglion neurons. To test the hypothesis that functional variants of NOS1 and NOS2A are asso...

journal_title：DNA and cell biology

authors： Gazquez I,Lopez-Escamez JA,Moreno A,Campbell CA,Meyer NC,Carey JP,Minor LB,Gantz BJ,Hansen MR,Della Santina CC,Aran I,Soto-Varela A,Santos S,Batuecas A,Perez-Garrigues H,Lopez-Nevot A,Smith RJ,Lopez-Nevot MA

更新日期：2011-09-01 00:00:00

abstract：:Global antibiotic resistance, driven by intensive antibiotic exposure/abuse, constitutes a serious challenge to all health care, particularly in an era when new antimicrobial development has slowed to a trickle. Recently, we published work demonstrating the discovery and partial mechanism of action of a novel bacteric...

journal_title：DNA and cell biology

authors： Hassett DJ,Meyer TJ

更新日期：2020-09-01 00:00:00

abstract：:KCNQ1 overlapping transcript 1 (KCNQ1OT1), a long noncoding RNA responsible for silencing a cluster of genes in cis, has been shown to be involved in multiple cancers. However, much remains unclear of how KCNQ1OT1 contributes to carcinogenesis. By thoroughly analyzing 510 hepatocellular carcinoma (HCC) cases and 1014 ...

journal_title：DNA and cell biology

authors： Wan J,Huang M,Zhao H,Wang C,Zhao X,Jiang X,Bian S,He Y,Gao Y

更新日期：2013-11-01 00:00:00

abstract：:Cytochrome P450 15 beta is a female-specific gene product that catalyzes the hydroxylation of steroid sulfates at the 15 beta position. Isolation and analysis of the gene for rat P450 15 beta reveals nine coding exons and encompasses more than 35 kb of chromosomal DNA. The intron-exon junctions are at similar position...

journal_title：DNA and cell biology

authors： Zaphiropoulos PG,Westin S,Ström A,Mode A,Gustafsson JA

更新日期：1990-01-01 00:00:00

abstract：:The CDC6 gene product from Saccharomyces cerevisiae is required for transition from late G1 to S phase of the cell cycle. We have investigated the subcellular localization of the CDC6 protein in yeast to explore where Cdc6p exerts its gene function (s). Using affinity-purified sera we localized Cdc6p to the cytoplasm ...

journal_title：DNA and cell biology

authors： Jong A,Young M,Chen GC,Zhang SQ,Chan C

更新日期：1996-10-01 00:00:00

abstract：:A safe and effective adjuvant is important to develop vaccines against highly pathogenic avian influenza virus. Chitosan, a derivative from the natural amino polysaccharide chitin, has been proved to be an effective adjuvant for inactivated influenza virus vaccine. In this study, protective immunity in mice provided b...

journal_title：DNA and cell biology

authors： Chang H,Li X,Teng Y,Liang Y,Peng B,Fang F,Chen Z

更新日期：2010-09-01 00:00:00

abstract：:A highly conserved aspartic acid residue present in the third membrane-spanning region of adrenergic and muscarinic receptors is directly involved in ligand binding. The five cloned somatostatin receptor subtypes also contain this residue at the same relative position. To test whether Asp-124 of the rat somatostatin r...

journal_title：DNA and cell biology

authors： Nehring RB,Meyerhof W,Richter D

更新日期：1995-11-01 00:00:00

abstract：:Nd1-S is the nuclear-localizing short variant form of Nd1 (Ivns1abp) encoding a Kelch family transcription factor. While the function of Nd1 has been investigated in the context of metastasis and doxorubicin-induced cardiotoxicity, little is known about its role in hematopoiesis. In this study, we investigated the fun...

journal_title：DNA and cell biology

authors： Lin Y,Luo Y,Hu F,Wang T,Dong Y,Yang D,He X,Chen X,Wang J,Du J,Zhang X

更新日期：2018-10-01 00:00:00

abstract：:Apoptosis, which is usually accompanied by DNA degradation, is important not only for the homeostasis of metazoans but also for mammalian development. If DNA is not properly degraded in these processes, it can cause diverse diseases, such as anemia, cataracts, and some autoimmune diseases. A large effort has been made...

journal_title：DNA and cell biology

authors： Liu MF,Wu XP,Wang XL,Yu YL,Wang WF,Chen QJ,Boireau P,Liu MY

更新日期：2008-05-01 00:00:00

abstract：:We previously showed that the human AKNA gene encodes an AT-hook transcription factor that regulates the expression of costimulatory cell surface molecules on lymphocytes. However, AKNA cDNA probes hybridize with multiple transcripts, suggesting either the existence of other homologous genes or a complex regulation op...

journal_title：DNA and cell biology

authors： Sims-Mourtada JC,Bruce S,McKeller MR,Rangel R,Guzman-Rojas L,Cain K,Lopez C,Zimonjic DB,Popescu NC,Gordon J,Wilkinson MF,Martinez-Valdez H

更新日期：2005-05-01 00:00:00

abstract：:The human ADH1A, ADH1B, and ADH1C genes encode alcohol dehydrogenases (ADHs) that metabolize ethanol. They evolved by recent tandem duplications and have similar proximal cis-acting elements, but differ in tissue-specificity. We hypothesized that distal cis-acting elements confer tissue-specificity. In this article, w...

journal_title：DNA and cell biology

authors： Chen HJ,Carr K,Jerome RE,Edenberg HJ

更新日期：2002-11-01 00:00:00

abstract：:Diabetes is a worldwide health problem with increasing prevalence. Some reports indicate the interplay between bone and glucose metabolism. The imbalance between bone resorption and formation resulted in the structural integrity and strength of bone. Glucagon-like peptide-1 (GLP-1) and its agonists (Liraglutide) have ...

journal_title：DNA and cell biology

authors： Gao L,Li SL,Li YK

更新日期：2018-12-01 00:00:00

abstract：:Most mammalian species express high concentrations of ALDH3A1 in corneal epithelium with the exception of the rabbit, which expresses high amounts of ALDH1A1 rather than ALDH3A1. Several hypotheses that involve catalytic and/or structural functions have been postulated regarding the role of these corneal ALDHs. The ai...

journal_title：DNA and cell biology

authors： Manzer R,Qamar L,Estey T,Pappa A,Petersen DR,Vasiliou V

更新日期：2003-05-01 00:00:00

abstract：:Homomeric and heteromeric interactions among cell-surface tyrosine kinase receptors belonging to the ErbB family lead to intracellular signaling cascades which are involved in cell activation, cytoskeletal interactions, and cellular transformation leading to neoplasia. Monoclonal antibodies which specifically bind to ...

journal_title：DNA and cell biology

authors： Peterson NC,Greene MI

更新日期：1998-12-01 00:00:00

abstract：:Ulcerative colitis (UC) is a long-time inflammatory condition arising from aberrant immune activation in the colon and the rectum. Interleukin (IL)-35 plays critical roles in autoimmune disorders. In this study, we explored the pathways of IL-35 in affecting UC. First, peripheral blood mononuclear cells (PBMCs) from U...

journal_title：DNA and cell biology

authors： Wang S,Qin C

更新日期：2017-05-01 00:00:00

abstract：:The spike (S) protein, a main surface antigen of the SARS coronavirus (SARS-CoV), is considered to be one of the most important protective antigen candidates for targets for vaccine design against the virus. In this study, a secreted recombinant expression plasmid, pVAX-S1, encoding the partial S protein with a signal...

journal_title：DNA and cell biology

authors： He H,Tang Y,Qin X,Xu W,Wang Y,Liu X,Liu X,Xiong S,Li J,Zhang M,Duan M

更新日期：2005-08-01 00:00:00

abstract：:CYP24A1 is overexpressed in colorectal cancer, and the reason for the dysregulation of CYP24A1 in colorectal cancer is still unknown. In the present study, experiments were designed to test whether CYP24A1 inhibition facilitated the antiproliferative effect of 1,25(OH)2D3. In addition, the role of methylation in the r...

journal_title：DNA and cell biology

authors： Sun H,Jiang C,Cong L,Wu N,Wang X,Hao M,Liu T,Wang L,Liu Y,Cong X

更新日期：2018-09-01 00:00:00

abstract：:The cDNAs encoding the human bone morphogenetic proteins BMP-2 and BMP-4 in an eukaryotic expression vector were permanently transferred into the murine mesenchymal progenitor cell line C3H10T1/2. Originally, these cells are known to differentiate into myotubes, adipocytes, and chondrocytes upon the addition of azacyt...

journal_title：DNA and cell biology

authors： Ahrens M,Ankenbauer T,Schröder D,Hollnagel A,Mayer H,Gross G

更新日期：1993-12-01 00:00:00

abstract：:The sugars will eventually be exported transporters (SWEET) gene family is a glycoprotein gene family that can regulate the transport of sugar in plants and plays an important role in plant growth and development, as well as in response to environmental stress. In this study, Kentucky bluegrass (cv. Baron) seedlings w...

journal_title：DNA and cell biology

authors： Zhang R,Niu K,Ma H

更新日期：2020-09-01 00:00:00

abstract：:The promoters of mammalian striated muscle actin gene contain binding sites for a number of transcription factors. Examples are the CArG boxes, which bind a protein identical to or related to serum response factor (SRF), E boxes, which bind myogenic determination factors such as MyoD and myogenin, and -CCGCCC- motifs,...

journal_title：DNA and cell biology

authors： Davey HW,Kelly JK,Wildeman AG

更新日期：1995-07-01 00:00:00

abstract：:Insulin-like growth factor I (IGF-I) plays a major role in development and metabolism. Currently, the cDNA-derived primary structure of IGF-I is known for some mammals and for chicken, frog, and salmon. Additionally, the organization of the human, rat, and chicken IGF-I genes has been established. The investigation of...

journal_title：DNA and cell biology

authors： Kavsan VM,Koval AP,Grebenjuk VA,Chan SJ,Steiner DF,Roberts CT Jr,LeRoith D

更新日期：1993-10-01 00:00:00

abstract：:Among environmental pollutants, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin) is one of the most potent tumor promoters and teratogens known. The molecular mechanisms responsible for the biological activity of TCDD, however, remain largely unknown. In this report, we show that the first observable effects of TCDD...

journal_title：DNA and cell biology

authors： Puga A,Nebert DW,Carrier F

更新日期：1992-05-01 00:00:00

abstract：:The expression of growth factors, proteolytic enzymes, fibrogenic factors, and cytokines is altered in the Helicobacter pylori-infected gastric mucosa. Therefore, we aimed to evaluate the association of functional promoter variants of transforming growth factor (TGF)-B1 and matrix metalloproteinase (MMP)-7 genes with ...

journal_title：DNA and cell biology

authors： Achyut BR,Ghoshal UC,Moorchung N,Mittal B

更新日期：2009-06-01 00:00:00

abstract：:Protein-RNA complexation is essential in cell biological functions. Transfer RNAs are bound to aminoacyl-tRNA synthetases for the translation of the genetic code during protein synthesis, while ribonucleoproteins bind RNA in posttranscriptional regulation of gene expression. A recent report showed the interacton of hu...

journal_title：DNA and cell biology

authors： Malonga H,Neault JF,Tajmir-Riahi HA

更新日期：2006-07-01 00:00:00

abstract：:Microsomal transfer protein (MTP), a lipid transfer protein localized in the endoplasmic reticulum of hepatocytes and enterocytes, plays an important role in the development of nonalcoholic fatty liver disease (NAFLD). Many existing studies have demonstrated that a common polymorphism (-493G>T, rs1800591 G>T) in the M...

journal_title：DNA and cell biology

authors： Zheng W,Wang L,Su X,Hu XF

更新日期：2014-06-01 00:00:00