The functions of Deoxyribonuclease II in immunity and development.

abstract：:Parkinson's disease (PD) is a serious neurodegenerative disorder that lacks effective therapeutic methods. In this research, expressions of PPARα, RXRα, and miR-21 were evaluated in PD patients and normal controls. To investigate the effects of miR-21, docosahexaenoic acid (DHA) and aspirin (ASA) on PD, as well as the...

journal_title：DNA and cell biology

authors： Fu Y,Zhen J,Lu Z

更新日期：2017-06-01 00:00:00

abstract：:Haplotypes formed by polymorphisms (T-786C, rs2070744; a variable number of tandem repeats in intron 4, and Glu298Asp, rs1799983) of the eNOS gene were associated previously with gestational hypertension (GH) and preeclampsia (PE). However, no study has explored the Tag SNPs rs743506 and rs7830 in these disorders. The...

journal_title：DNA and cell biology

authors： Muniz L,Luizon MR,Palei AC,Lacchini R,Duarte G,Cavalli RC,Tanus-Santos JE,Sandrim VC

更新日期：2012-12-01 00:00:00

abstract：:CXXC finger protein 1 (CFP1) is a component of the Setd1A and Setd1B methyltransferase complexes, localizes to euchromatic regions of the genome, and specifically binds unmethylated CpG dinucleotides in DNA. Murine embryos lacking CFP1 exhibit peri-implantation lethality, a developmental time that correlates with glob...

journal_title：DNA and cell biology

authors： Butler JS,Lee JH,Skalnik DG

更新日期：2008-10-01 00:00:00

abstract：:Polymorphisms such as single-nucleotide polymorphisms (SNPs) and insertions/deletions (Indels) can be associated with phenotypic traits and be used as markers for disease diagnosis. Identification of these genetic variations within laboratory mice is crucial to improve our understanding of the genetic background of th...

journal_title：DNA and cell biology

authors： Lo CL,Shen F,Baumgarner K,Cramer MJ,Lossie AC

更新日期：2012-03-01 00:00:00

abstract：:Design and synthesis of new small molecules binding to double-stranded RNA necessitate complete understanding of the molecular aspects of the binding of many existing molecules. Toward this goal, in this work we evaluated the biophysical aspects of the interaction of a DNA intercalator (proflavine) and a minor groove ...

journal_title：DNA and cell biology

authors： Sinha R,Hossain M,Kumar GS

更新日期：2009-04-01 00:00:00

abstract：:The human ADH1A, ADH1B, and ADH1C genes encode alcohol dehydrogenases (ADHs) that metabolize ethanol. They evolved by recent tandem duplications and have similar proximal cis-acting elements, but differ in tissue-specificity. We hypothesized that distal cis-acting elements confer tissue-specificity. In this article, w...

journal_title：DNA and cell biology

authors： Chen HJ,Carr K,Jerome RE,Edenberg HJ

更新日期：2002-11-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate mRNAs through a sequence-specific mechanism. By virtue of their structure and mechanism of action, computational methods have been devised to investigate the encoding of miRNA genes and the targets of miRNA action. A variety of assumptions have predic...

journal_title：DNA and cell biology

authors： Doran J,Strauss WM

更新日期：2007-05-01 00:00:00

abstract：:Uterine corpus endometrial carcinoma (UCEC) is a common malignancy in the female reproductive system, associated with high morbidity and mortality. Despite the high prevalence of UCEC, molecular understanding of uterine endothelium tumorigenesis remains poorly understood. In this study, we reported that transcription ...

journal_title：DNA and cell biology

authors： Li Q,Lei Y,Du W

更新日期：2018-05-01 00:00:00

abstract：:The mdmx gene was shown to possess high homology to the mdm-2 gene and to encode a protein that can bind p53 and block p53 transactivation. Because Mdm-2 protein blocks the growth-suppressive activity of the p53 tumor-suppressor protein through similar activities, we examined the expression patterns of mdmx to determi...

journal_title：DNA and cell biology

authors： Jackson MW,Berberich SJ

更新日期：1999-09-01 00:00:00

abstract：:Polyhomeotic is a member of the Polycomb group of genes. The products of this group are chromatin-associated proteins that act together as multimeric complexes. These proteins are required for the maintenance of target gene repression in a permanent and heritable manner during development. In order to better understan...

journal_title：DNA and cell biology

authors： Netter S,Faucheux M,Théodore L

更新日期：2001-08-01 00:00:00

abstract：:Heme plays a significant pathogenic role in several diseases involving the kidney. The cellular content of heme, derived either from the delivery of filtered heme proteins such as hemoglobin and myoglobin, or from the breakdown of ubiquitous intracellular heme proteins, is regulated via the heme oxygenase enzyme syste...

journal_title：DNA and cell biology

authors： Hill-Kapturczak N,Chang SH,Agarwal A

更新日期：2002-04-01 00:00:00

abstract：:A nomenclature system for the UDP glucuronosyltransferase superfamily is proposed, based on divergent evolution of the genes. A total of 26 distinct cDNAs in five mammalian species have been sequenced to date. Comparison of the deduced amino acid sequences leads to the definition of two families and a total of three s...

journal_title：DNA and cell biology

authors： Burchell B,Nebert DW,Nelson DR,Bock KW,Iyanagi T,Jansen PL,Lancet D,Mulder GJ,Chowdhury JR,Siest G

更新日期：1991-09-01 00:00:00

abstract：:Palindromati, the massive host-edited synthetic palindromic contamination found in GenBank, is illustrated and exemplified. Millions of contaminated sequences with portions or tandems of such portions derived from the ZAP adaptor or related linkers are shown (1) by the 12-bp sequence reported elsewhere, exon Xb, 5' CC...

journal_title：DNA and cell biology

authors： Castro-Chavez F

更新日期：2012-02-01 00:00:00

abstract：:Xenotransplantation from pigs to human beings is viewed as a potential solution for the acute organ shortage. However, consequent xenorejection induced by Gal alpha 1,3 Gal (a Gal, Gal antigen) prevents xenotransplantation from clinical application. Thus, the most attracting attempt to prevent xenorejection is the eli...

journal_title：DNA and cell biology

authors： Yu L,Miao H,Guo L

更新日期：2005-04-01 00:00:00

abstract：:Peanut is an important crash crop worldwide, and it is often threatened by drought stress due to unexpected extreme weather events. In this work, NH5 and FH18 were selected as drought-tolerant and drought-sensitive varieties, respectively. Comparison of their physiological responses revealed that NH5 showed less wilti...

journal_title：DNA and cell biology

authors： Ren J,Zhang H,Shi X,Ai X,Dong J,Zhao X,Zhong C,Jiang C,Wang J,Yu H

更新日期：2020-12-29 00:00:00

abstract：:Ginsenoside, a natural triterpenoid saponin, exhibits immunomodulatory and anticancer activities. In the present study, we demonstrated that ginsenoside Rg1 induced secretion of cytokines, including interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α), and IL-1β, and chemokines such as IL-8 and IP-10 in a dose-depe...

journal_title：DNA and cell biology

authors： Huang Y,Zou Y,Lin L,Zheng R

更新日期：2017-12-01 00:00:00

abstract：:The liver has an excellent capacity for regeneration when faced with external injury and the damage differs from that of other organs in the body. Our aim was to identify the role of circular RNA (circRNA) during the DNA synthesis phase (36 h) of mice liver regeneration. High-throughput RNA sequencing was conducted to...

journal_title：DNA and cell biology

authors： Zhang J,Xu L,Wang P,Zheng X,Hu Y,Luo J,Zhang M,Xu M

更新日期：2020-11-01 00:00:00

abstract：:Apicomplexa is a phylum within the kingdom Protista that contains some of the most significant threats to public health. One of the members of this phylum, Toxoplasma gondii, is amenable to molecular genetic analyses allowing for the identification of factors critical for colonization and disease. A pathway found to b...

journal_title：DNA and cell biology

authors： Frankel MB,Knoll LJ

更新日期：2009-06-01 00:00:00

abstract：:We have analyzed the interleukin-1 beta (IL-1 beta) promoter region near the cap site. Specific DNA sequences required for lipopolysaccharide (LPS) induction within this region were identified using transfection of reporter plasmids that contained portions of the proximal IL-1 beta 5'-flanking sequence. An LPS-respons...

journal_title：DNA and cell biology

authors： Godambe SA,Chaplin DD,Takova T,Bellone CJ

更新日期：1994-06-01 00:00:00

abstract：:FOXO3 is a member of the Forkhead box class O (FOXO) transcription factor family that modulates the transcription of target genes in a variety of cellular functions in lower animals to mammals. It has been implicated in the attenuation of insulin-signaling pathways, including having a potential role in lifespan contro...

journal_title：DNA and cell biology

authors： Byun SO,Zhou H,Hickford JG

更新日期：2011-07-01 00:00:00

abstract：:A yeast two-hybrid system was used to identify mutants of Max that exhibit an increased affinity for Myc. Truncated forms of the Max helix-loop-helix/leucine zipper motif (HLH/Zip) were first expressed in a two- hybrid system in which the bait protein was the HLH/Zip motif of Myc. Deletion of amino acids both amino-te...

journal_title：DNA and cell biology

authors： Wang H,Van Den Bergh F,Spencer E,Wilcox K,Herman T

更新日期：1997-11-01 00:00:00

abstract：:Extracellular vesicles classified as exosomes, microvesicles, or apoptotic bodies based on size are shed from most cells under normal as well as pathological conditions. They are released into the surrounding milieu, including plasma, urine, saliva, and tissues. Exosomes are highly enriched in microRNAs (miRs), which ...

journal_title：DNA and cell biology

authors： Pulliam L,Gupta A

更新日期：2015-07-01 00:00:00

abstract：:We evaluated the effects of administration of 1,25-dihydroxyvitamin D (1,25(OH)2D) during pregnancy on relieving adverse outcomes of preeclampsia and the pathologic and biochemical changes in reduction in uteroplacental perfusion (RUPP) model of rats. On day 1, 7, and 14 of pregnancy, rats in pregnant RUPP plus 1,25(O...

journal_title：DNA and cell biology

authors： Tian X,Ma S,Wang Y,Hou L,Shi Y,Yao M,Wang X,Zhang H,Jiang L

更新日期：2016-02-01 00:00:00

abstract：:In a systematic approach to identify interferon-gamma (IFN-gamma)-regulated host effector molecules, we found several members of the 65 kDa guanylate-binding proteins (GBPs) highly upregulated. During extensive characterization of these guanosine triphosphatases (GTPases), we identified discrepancies between the clone...

journal_title：DNA and cell biology

authors： Konermann C,Kresse A,Beuter-Gunia C,Würthner J,Degrandi D,Pfeffer K,Beer S

更新日期：2007-12-01 00:00:00

abstract：:The distribution and evolutionary pattern of the conserved microsatellite repeat sequences (CA)n, (TGG)6, and (GGAT)4 were studied to determine the divergence time and phylogenetic position of the water buffalo, Bubalus bubalis. The mean allelic frequencies of these repeat loci showed a high level of heterozygosity am...

journal_title：DNA and cell biology

authors： Mattapallil MJ,Ali S

更新日期：1999-06-01 00:00:00

abstract：:Antibody-targeting therapy has drawn great interests to the hematologists and oncologists. 3A4, a novel antibody recognizing human CD45RA antigen, is a new target molecule for leukemias and holds a therapeutic potential for myeloid lineage leukemias. However, murine antibodies cannot be safely used in patients because...

journal_title：DNA and cell biology

authors： Li S,Shen D,Guo X,Liao C,Tang Y

更新日期：2018-09-01 00:00:00

abstract：:Mammalian cumulus-oocyte complexes (COCs) reach full developmental capability during folliculogenesis and oogenesis. It is well recognized that only gametes achieving MII stage after in vivo or in vitro maturation (IVM) are successfully fertilized by a single spermatozoon. Although the process of oocyte nuclear and/or...

journal_title：DNA and cell biology

authors： Budna J,Bryja A,Celichowski P,Kranc W,Ciesiółka S,Borys S,Rybska M,Kolecka-Bednarczyk A,Jeseta M,Bukowska D,Antosik P,Brüssow KP,Bruska M,Nowicki M,Zabel M,Kempisty B

更新日期：2017-08-01 00:00:00

abstract：:Electroporation has proven to be a highly effective technique for the in vivo delivery of genes to a number of solid tissues. In most of the reported methods, DNA is injected into the target tissue and electrodes are placed directly on or in the tissue for application of the electric field. While this works well for s...

journal_title：DNA and cell biology

authors： Dean DA

更新日期：2003-12-01 00:00:00

abstract：:Intracranial aneurysms (IAs) and potential IA rupture are one of the direct causes of permanent brain damage and mortality. Interestingly, the major risk factors of IA development, including hemodynamic stress, hypertension, smoking, and genetic predispositions, are closely associated with a proinflammatory immune sta...

journal_title：DNA and cell biology

authors： Zhang HF,Zhao MG,Liang GB,Yu CY,He W,Li ZQ,Gao X

更新日期：2016-02-01 00:00:00

abstract：:The computer program, SIGSEQ2, was used to select heterologous signal peptides from a catalog of published sequences to express the echistatin gene in insect (Sf9) cells. S-values for each amino acid were determined to select empirically the site of cleavage between the signal peptide and mature echistatin. Five gene ...

journal_title：DNA and cell biology

authors： Daugherty BL,Zavodny SM,Lenny AB,Jacobson MA,Ellis RW,Law SW,Mark GE

更新日期：1990-07-01 00:00:00