Heme oxygenase and the kidney.


:Heme plays a significant pathogenic role in several diseases involving the kidney. The cellular content of heme, derived either from the delivery of filtered heme proteins such as hemoglobin and myoglobin, or from the breakdown of ubiquitous intracellular heme proteins, is regulated via the heme oxygenase enzyme system. Heme oxygenases catalyze the rate-limiting step in heme degradation, resulting in the formation of iron, carbon monoxide, and biliverdin, which is subsequently converted to bilirubin by biliverdin reductase. Recent attention has focused on the biological effects of product(s) of this enzymatic reaction, which have important antioxidant, anti-inflammatory, and cytoprotective functions. Three isoforms of heme oxygenase (HO) enzyme have been described: an inducible isoform, HO-1, and two constitutively expressed isoforms, HO-2 and HO-3. Induction of HO-1 occurs as an adaptive and beneficial response to several injurious stimuli, and has been implicated in many clinically relevant disease states including atherosclerosis, transplant rejection, endotoxic shock, hypertension, acute lung injury, acute renal injury, as well as others. This review will focus predominantly on the role of HO-1 in the kidney.


DNA Cell Biol


DNA and cell biology


Hill-Kapturczak N,Chang SH,Agarwal A





Has Abstract


2002-04-01 00:00:00












  • Ras is involved in gap junction closure in proliferating fibroblasts or preadipocytes but not in differentiated adipocytes.

    abstract::A decrease in gap junctional, intercellular communication (GJIC) has been associated with cells neoplastically transformed by a variety of factors. To investigate the role of the Ras oncogene product in gap junction function, a panel of murine C3H10T1/2 (10T1/2) fibroblasts was constructed in which the levels of ras g...

    journal_title:DNA and cell biology

    pub_type: 杂志文章


    authors: Brownell HL,Narsimhan RP,Corbley MJ,Mann VM,Whitfield JF,Raptis L

    更新日期:1996-06-01 00:00:00

  • A single expression site with a conserved leader sequence regulates variation of expression of the Pneumocystis carinii family of major surface glycoprotein genes.

    abstract::The major surface glycoprotein (MSG) of Pneumocystis carinii is encoded by a family of related but distinct genes distributed throughout the P. carinii genome. Previous reports of the genomic and mRNA MSG structure suggested that there was a highly conserved 5'-untranslated region and a highly variable translated regi...

    journal_title:DNA and cell biology

    pub_type: 杂志文章


    authors: Edman JC,Hatton TW,Nam M,Turner R,Mei Q,Angus CW,Kovacs JA

    更新日期:1996-11-01 00:00:00

  • CpG array analysis of histone H3 lysine 4 trimethylation in peripheral blood mononuclear cells of uremia patients.

    abstract::Studies of the epigenome have attracted little interest in nephrology, especially in uremia. Several lines of evidence have suggested that there are links between genomic DNA hypomethylation and cardiovascular complications in uremia patients. However, to date, our knowledge about the alterations in histone methylatio...

    journal_title:DNA and cell biology

    pub_type: 杂志文章


    authors: Zhang L,Dai Y,Wang L,Peng W,Zhang Y,Ou Y,Lu J

    更新日期:2011-03-01 00:00:00

  • Use of the polymerase chain reaction for the detection of alternatively spliced mRNAs of plasma membrane calcium pump.

    abstract::Polymerase chain reaction [PCR, reverse transcriptase-PCR (RT-PCR)] has been used to amplify the mRNA subspecies of the plasma membrane calcium pump isoform 1 (PMCA1) in total RNA extracted from hamster tissues. Two primers were synthesized that encompass the site at which a 154-bp exon is included totally (PMCA1a), p...

    journal_title:DNA and cell biology

    pub_type: 杂志文章


    authors: Sarkar FH,Ball DE,Tsang W,Li YW,Kuo TH

    更新日期:1993-06-01 00:00:00

  • Functional dissection of the HNF-1alpha transcription factor: a study on nuclear localization and transcriptional activation.

    abstract::Hepatocyte nuclear factor-1alpha (HNF-1alpha) is a homeodomain-containing transcription factor regulating the expression of liver and pancreas-specific genes. Mutations in the HNF-1alpha-encoding gene TCF1 cause maturity-onset diabetes of the young, type 3 (MODY3). These mutations may affect nuclear import or reduce t...

    journal_title:DNA and cell biology

    pub_type: 杂志文章


    authors: Bjørkhaug L,Bratland A,Njølstad PR,Molven A

    更新日期:2005-11-01 00:00:00

  • Construction of a eukaryotic expression plasmid encoding partial S gene fragments of the SARS-CoV and its potential utility as a DNA vaccine.

    abstract::The spike (S) protein, a main surface antigen of the SARS coronavirus (SARS-CoV), is considered to be one of the most important protective antigen candidates for targets for vaccine design against the virus. In this study, a secreted recombinant expression plasmid, pVAX-S1, encoding the partial S protein with a signal...

    journal_title:DNA and cell biology

    pub_type: 杂志文章


    authors: He H,Tang Y,Qin X,Xu W,Wang Y,Liu X,Liu X,Xiong S,Li J,Zhang M,Duan M

    更新日期:2005-08-01 00:00:00

  • Glucose response elements in a gene that codes for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

    abstract::We have shown previously that rat hepatoma FTO-2B cells express two mRNAs, called F (fetal) and L (liver), from distinct promoters of the same gene coding for 6-phosphofructo-2-kinase (PFK-2). This enzyme catalyzes the synthesis of fructose 2,6-bisphosphate, an allosteric stimulator of glycolysis. We have now found th...

    journal_title:DNA and cell biology

    pub_type: 杂志文章


    authors: Dupriez VJ,Rousseau GG

    更新日期:1997-09-01 00:00:00

  • Functional variants in NOS1 and NOS2A are not associated with progressive hearing loss in Ménière's disease in a European Caucasian population.

    abstract::Hearing loss in Ménière's disease (MD) is associated with loss of spiral ganglion neurons and hair cells. In a guinea pig model of endolymphatic hydrops, nitric oxide synthases (NOS) and oxidative stress mediate loss of spiral ganglion neurons. To test the hypothesis that functional variants of NOS1 and NOS2A are asso...

    journal_title:DNA and cell biology

    pub_type: 杂志文章


    authors: Gazquez I,Lopez-Escamez JA,Moreno A,Campbell CA,Meyer NC,Carey JP,Minor LB,Gantz BJ,Hansen MR,Della Santina CC,Aran I,Soto-Varela A,Santos S,Batuecas A,Perez-Garrigues H,Lopez-Nevot A,Smith RJ,Lopez-Nevot MA

    更新日期:2011-09-01 00:00:00

  • Cloning and characterization of two human polyspecific organic cation transporters.

    abstract::Previously we cloned a polyspecific transporter from rat (rOCT1) that is expressed in renal proximal tubules and hepatocytes and mediates electrogenic uptake of organic cations with different molecular structures. Recently a homologous transporter from rat kidney (rOCT2) was cloned but not characterized in detail. We ...

    journal_title:DNA and cell biology

    pub_type: 杂志文章


    authors: Gorboulev V,Ulzheimer JC,Akhoundova A,Ulzheimer-Teuber I,Karbach U,Quester S,Baumann C,Lang F,Busch AE,Koepsell H

    更新日期:1997-07-01 00:00:00

  • Associations of fibroblast growth factor 21 gene 3' untranslated region single-nucleotide polymorphisms with metabolic syndrome, obesity, and diabetes in a Han Chinese population.

    abstract::Fibroblast growth factor 21 (FGF-21) is a novel regulator for metabolic syndrome (MetS), diabetes, and obesity. However, no study has been performed on the association of these diseases with FGF-21 gene polymorphism. The aim of the study was to investigate the association of 3' untranslated region (UTR) single-nucleot...

    journal_title:DNA and cell biology

    pub_type: 杂志文章


    authors: Zhang M,Zeng L,Wang YJ,An ZM,Ying BW

    更新日期:2012-04-01 00:00:00

  • Regulation of the urokinase gene by the retinoblastoma protein.

    abstract::The promoter of the human urokinase plasminogen activator (uPA) gene contains a sequence identical with the retinoblastoma control element (RCE) of the murine c-fos gene, as well as several Sp1 binding sites. In a number of cell lines, the uPA promoter is activated during enforced expression of the retinoblastoma prot...

    journal_title:DNA and cell biology

    pub_type: 杂志文章


    authors: Novak U,Paradiso L,Hamilton JA

    更新日期:1994-11-01 00:00:00

  • Downstream sequence adjacent to AUG affects translation of chloramphenicol acetyl transferase in eukaryotic cells.

    abstract::The CAT gene is widely used as a reporter in eukaryotic systems because of the efficient translation of its mRNA. We report here that a sequence occurring in the CAT mRNA at +15 nucleotides from CAT AUG is essential for translation. This sequence includes a stem-loop structure, which, however, exhibits a calculated st...

    journal_title:DNA and cell biology

    pub_type: 杂志文章


    authors: Ciullo M,Del Pozzo G,Autiero M,Guardiola J

    更新日期:2000-01-01 00:00:00

  • A major constituent of green tea, EGCG, inhibits the growth of a human cervical cancer cell line, CaSki cells, through apoptosis, G(1) arrest, and regulation of gene expression.

    abstract::A constituent of green tea, (-)-epigallocatechin-3-gallate (EGCG) has been known to possess antiproliferative properties. In this study, we investigated the anticancer effects of EGCG in human papillomavirus (HPV)-16 associated cervical cancer cell line, CaSki cells. The growth inhibitory mechanism(s) and regulation o...

    journal_title:DNA and cell biology

    pub_type: 杂志文章


    authors: Ahn WS,Huh SW,Bae SM,Lee IP,Lee JM,Namkoong SE,Kim CK,Sin JI

    更新日期:2003-03-01 00:00:00

  • Comprehensive Analysis of Gene Expression Profiles of Sepsis-Induced Multiorgan Failure Identified Its Valuable Biomarkers.

    abstract::Sepsis is an inflammatory-related disease, and severe sepsis would induce multiorgan dysfunction, which is the most common cause of death of patients in noncoronary intensive care units. Progression of novel therapeutic strategies has proven to be of little impact on the mortality of severe sepsis, and unfortunately, ...

    journal_title:DNA and cell biology

    pub_type: 杂志文章


    authors: Wang Y,Yin X,Yang F

    更新日期:2018-02-01 00:00:00

  • The effect of progestins on prolactin receptor gene transcription in human breast cancer cells.

    abstract::The sex steroid hormone progesterone modulates the developmental and lactogenic activity of prolactin in the mammary gland. Regulation of the level of prolactin receptor (PRLR) provides one possible mechanism by which this may occur, prompting this investigation of the molecular mechanisms involved in progestin regula...

    journal_title:DNA and cell biology

    pub_type: 杂志文章


    authors: Ormandy CJ,Graham J,Kelly PA,Clarke CL,Sutherland RL

    更新日期:1992-12-01 00:00:00

  • Biological and Clinical Relevance of microRNAs in Mitochondrial Diseases/Dysfunctions.

    abstract::Mitochondrial dysfunction arises from an inadequate number of mitochondria, an inability to provide necessary substrates to mitochondria, or a dysfunction in their electron transport and a denosine triphosphate synthesis machinery. Occurrences of mitochondrial dysfunction are due to genetic or environmental changes in...

    journal_title:DNA and cell biology

    pub_type: 杂志文章,评审


    authors: Sekar D,Johnson J,Biruntha M,Lakhmanan G,Gurunathan D,Ross K

    更新日期:2020-08-01 00:00:00

  • The effect of DYS-14 copy number variations on extracellular fetal DNA quantification in maternal circulation.

    abstract::The aims of our research involved to investigate DYS-14 copy number variations in healthy males, to quantify extracellular DNA in maternal circulation in normal versus complicated pregnancies, and to study variations in the DYS-14 copy number in extracellular male fetal DNA. Fifty-five healthy males, 43 uncomplicated ...

    journal_title:DNA and cell biology

    pub_type: 杂志文章


    authors: Hromadnikova I,Benesova M,Zejskova L,Stehnova J,Doucha J,Sedlacek P,Dlouha K,Krofta L

    更新日期:2009-07-01 00:00:00

  • High-copy expression vector based on amplification-promoting sequences.

    abstract::We describe a new vector system that allows efficient expression of heterologous proteins in transformed mouse L fibroblasts. This is due to its persistence at high copy numbers, achieved by a 370-bp amplification promoting element (muNTS1) derived from the nontranscribed spacer of murine rDNA. Copy number determinati...

    journal_title:DNA and cell biology

    pub_type: 杂志文章


    authors: Hemann C,Gärtner E,Weidle UH,Grummt F

    更新日期:1994-04-01 00:00:00

  • Expression and export in Escherichia coli of fusion proteins containing carboxy-terminally located honeybee prepromelittin.

    abstract::The aim of this work was to express a eukaryotic pre-protein in Escherichia coli so that it could be obtained intact, without cleavage, by bacterial leader peptidase. To this end, cDNA coding for honeybee prepromelittin was ligated to the 3' end of genes coding for truncated forms of either Protein A or beta-galactosi...

    journal_title:DNA and cell biology

    pub_type: 杂志文章


    authors: He M,Liu H,Austen B

    更新日期:1994-08-01 00:00:00

  • Decreased Hnf-1 gene expression in mice homozygous for a 1.2-centiMorgan deletion on chromosome 7.

    abstract::The mammalian CYP2E1 gene encodes a cytochrome P450 enzyme that is markedly increased soon after birth. In vitro evidence suggests that the rat CYP2E1 gene is positively regulated by the transcription factor HNF-1 or a protein displaying DNA-binding properties similar to HNF-1. In contrast to newborn wild-type mice an...

    journal_title:DNA and cell biology

    pub_type: 杂志文章


    authors: Gonzalez FJ,Liu SY,Kozak CA,Nebert DW

    更新日期:1990-12-01 00:00:00

  • Isolation and biological characteristics of chicken adipose-derived progenitor cells.

    abstract::Adipose-derived stem cells/adipose-derived progenitor cells (ADPCs) are multipotent stem cells that can differentiate in vitro into many cell types. However, the vast majority of experimental materials were obtained from human, mouse, rabbit, and other mammals but rarely from poultry. In this study, ADPCs were isolate...

    journal_title:DNA and cell biology

    pub_type: 杂志文章


    authors: Gong X,Hou L,Bai C,Jin D,He X,Guan W,Ma Y

    更新日期:2011-07-01 00:00:00

  • Gene set enrichment analysis reveals several globally affected pathways due to SKI-1/S1P inhibition in HepG2 cells.

    abstract::Sterol regulatory element-binding proteins (SREBPs) are transcription factors governing transcription of genes related to cholesterol and fatty acid metabolism. To become active, SREBPs must undergo a proteolytic cleavage to allow an active NH(2)-terminal segment to translocate into the nucleus. SKI-1/S1P is the first...

    journal_title:DNA and cell biology

    pub_type: 杂志文章


    authors: De Windt A,Rai M,Bernier L,Thelen K,Soini J,Lefebvre C,Chintawar S,Lavigne J,Saarinen L,Kytömäki L,Munzer JS,Lütjohann D,Pandolfo M,Davignon J,Seidah NG,Laaksonen R

    更新日期:2007-11-01 00:00:00

  • Characterization of the cDNA coding for mouse prothrombin and localization of the gene on mouse chromosome 2.

    abstract::A series of overlapping cDNAs coding for mouse prothrombin (coagulation factor II) have been isolated and the composite DNA sequence has been determined. The complete prothrombin cDNA is 1,987 bp in length [excluding the poly(A) tail] and codes for 18 bp of 5' untranslated sequence, an open reading frame coding for 61...

    journal_title:DNA and cell biology

    pub_type: 杂志文章


    authors: Degen SJ,Schaefer LA,Jamison CS,Grant SG,Fitzgibbon JJ,Pai JA,Chapman VM,Elliott RW

    更新日期:1990-09-01 00:00:00

  • CFP1 interacts with DNMT1 independently of association with the Setd1 Histone H3K4 methyltransferase complexes.

    abstract::CXXC finger protein 1 (CFP1) is a component of the Setd1A and Setd1B methyltransferase complexes, localizes to euchromatic regions of the genome, and specifically binds unmethylated CpG dinucleotides in DNA. Murine embryos lacking CFP1 exhibit peri-implantation lethality, a developmental time that correlates with glob...

    journal_title:DNA and cell biology

    pub_type: 杂志文章


    authors: Butler JS,Lee JH,Skalnik DG

    更新日期:2008-10-01 00:00:00

  • SLC34A2 Regulates the Proliferation, Migration, and Invasion of Human Osteosarcoma Cells Through PTEN/PI3K/AKT Signaling.

    abstract::Osteosarcoma (OS) is a bone malignancy with high incidence. The underlying molecular mechanisms that are associated with the development of OS need further investigation. In this study, we showed that SLC34A2, a member of the solute carrier gene family, was significantly downregulated in OS patients and cell lines. Ov...

    journal_title:DNA and cell biology

    pub_type: 杂志文章


    authors: Liu X,Zhou X,Xu H,He Z,Shi X,Wu S

    更新日期:2017-09-01 00:00:00

  • Investigation of polymorphic variants of PPARD and APOE genes in Turkish coronary heart disease patients.

    abstract::The aim of this study was to determine the role of polymorphic variants of apolipoprotein E (APOE) and peroxisome proliferator-activated receptor delta (PPARD) genes in the development of coronary heart disease (CHD), and the PPARD and APOE gene-gene interaction in a Turkish population. This study was carried out usin...

    journal_title:DNA and cell biology

    pub_type: 杂志文章


    authors: Yılmaz-Aydogan H,Kucukhuseyin O,Kurnaz O,Akadam-Teker B,Kurt O,Tekeli A,Ozturk O,Isbir T

    更新日期:2012-05-01 00:00:00

  • Bio-informatic trends for the determination of miRNA-target interactions in mammals.

    abstract::MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate mRNAs through a sequence-specific mechanism. By virtue of their structure and mechanism of action, computational methods have been devised to investigate the encoding of miRNA genes and the targets of miRNA action. A variety of assumptions have predic...

    journal_title:DNA and cell biology

    pub_type: 杂志文章


    authors: Doran J,Strauss WM

    更新日期:2007-05-01 00:00:00

  • Cytosine Methylation of Isoflavone Synthase Gene in the Genic Region Positively Regulates Its Expression and Isoflavone Biosynthesis in Soybean Seeds.

    abstract::Plants, being sessile organisms, have evolved several dynamic mechanisms of gene regulation. Epigenetic modification especially cytosine methylation and demethylation actively regulates the expression of genes. To understand the role of cytosine methylation during isoflavonoid biosynthesis and accumulation, we perform...

    journal_title:DNA and cell biology

    pub_type: 杂志文章


    authors: Gupta OP,Dahuja A,Sachdev A,Jain PK,Kumari S,T V,Praveen S

    更新日期:2019-06-01 00:00:00

  • HMGA1 Mediated High-Glucose-Induced Vascular Smooth Muscle Cell Proliferation in Diabetes Mellitus: Association Between PI3K/Akt Signaling and HMGA1 Expression.

    abstract::High-mobility group protein A1 (HMGA1), an architectural transcription factor, was found to regulate multiple gene expression in mammals. Recent studies firmly indicate an association between HMGA1 and type 2 diabetes. However, the presence and function of HMGA1 in diabetic vasculopathy has not been substantiated. in ...

    journal_title:DNA and cell biology

    pub_type: 杂志文章


    authors: Zhang Q,Chen L,Zhao Z,Wu Y,Zhong J,Wen G,Cao R,Zu X,Liu J

    更新日期:2018-04-01 00:00:00

  • Bioinformatics Analysis of the Core Genes Related to Lupus Nephritis Through a Network and Pathway-Based Approach.

    abstract::In this study, we explored the genes genetically associated with lupus nephritis (LN), and their function by bioinformatics analysis. We collected genes potentially associated with LN from National Center for Biotechnology Information Center (NCBI-Gene) and Online Mendelian Inheritance in Man (OMIM) databases. The maj...

    journal_title:DNA and cell biology

    pub_type: 杂志文章


    authors: Sun G,Zhu P,Dai Y,Chen W

    更新日期:2019-07-01 00:00:00